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Basile Lab

Basile Research Group

Franco Basile, Ph.D., Principal Investigator

Dept 3838

Department of Chemistry

Department of Chemistry

University of Wyoming

1000 E. University Ave.

Office (307) 766-4376

Laramie, WY 82071

Email: basile@uwyo.edu

Alsike Research Group

Chemical Biology

Research project funded by the National Science Foundation, NSF-IOS: "Why do bacteria make sterols?", PI: N. Ward, co-PI: F. Basile

NSF

Metabolomics/Lipidomics of bacteria

This evolutionary biology project aims at elucidating why some bacteria make sterols

Our laboratory implements several MS techniques (GC-MS, GC-MS/MS, LC-ESI-MS/MS and LC offline MALDI-MS/MS) for the analysis of lipids, carbohydrates and metabolites in microorganisms.  Recent work from our laboratory identified several hydroxy-fatty acids (some believed to be associated with lipid A) and polyunsaturated fatty acids in the microorganism Gemmata obscuriglobus. (Project in collaboration with Dr. Naomi Ward; Read the article in J. Bacteriology, 2016, 198, 221-236 journal link).

 GC-MS of G. ob fatty acids

Terbinafine treatment, a suppresor of sterol synthesis, in Gemmata obscuriglobus inhibits normal budding replication (left). Quantitation of sterols in G. obscuriglobus after being treated with terbinafine (right). Figures from: "Essentiality of sterol synthesis genes in the planctomycete bacterium Gemmata obscuriglobus", Elena Rivas-Marin, Sean Stettner, Ekaterina Y. Gottshall, Carlos Santana-Molina, Mitch Helling, Franco Basile, Naomi L. Ward & Damien P. Devos, Nature Communications | (2019) 10:2916 | https://doi.org/10.1038/s41467-019-10983-7

 gob_sterol_quant.png

 

MICROBESTIARY: Understand science thourgh art  Microbestiary hopes to show, in welcoming and memorable ways, that the bustling microbial world is populated by strange and beautiful characters that are themselves quite charismatic

 

Contact Us

Basile Lab

Basile Research Group

Franco Basile, Ph.D., Principal Investigator

Dept 3838

Department of Chemistry

Department of Chemistry

University of Wyoming

1000 E. University Ave.

Office (307) 766-4376

Laramie, WY 82071

Email: basile@uwyo.edu

Alsike Research Group

1000 E. University Ave. Laramie, WY 82071
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