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Division of Kinesiology and Health

College of Health Sciences

Danielle (Nellie) R. Bruns, Ph.D.

Assistant Professor

dbruns1@uwyo.edu • (307) 766-5290 • Corbett 116

Danielle Bruns

EDUCATION

  • PhD. Human Bioenergetics, Colorado State University (2013)
  • MS. Health and Exercise Science, Colorado State University (2010)
  • BS. Exercise Science, Linfield College (2008)

 

RESEARCH INTERESTS

Dr. Bruns is interested in the molecular mechanisms underlying heart disease and heart failure. Her research focuses on the impact of age on the failing right heart, sex differences in heart failure development and treatment, exercise as medicine for heart failure, and the identification of new therapies for the treatment of cardiac disease.

 

TEACHING

  • HM 6630: Circulatory, Pulmonary, and Renal Systems

 

AFFILIATONS

  • American Heart Association
  • American Physiological Association
  • Gerontological Society of America

 

GRANTS, HONORS, AWARDS

 
Grants

  • NIH/NIA. K01 Mentored Research Scientist Development Award (9/1/2018-8/31/2023). “Therapeutic activation of AMPK for the aging right heart.”
  • American Heart Association, Southwest Affiliate Postdoctoral Fellowship (1/1/2017-8/15/2018). “Hypobaric hypoxia-induced epigenetic changes of the cardiac fibroblast.”
  • American College of Sports Medicine Foundation Predoctoral Grant (6/1/2012-6/30/2013). “Selective translation of mitochondrial proteins during energetic stress”.

 

Honors and Awards

  • 2018 NIA Summer Training Course on Biology of Aging
  • 2016 NIH/NIA Butler-Williams Scholar
  • 2016 American Physiological Society: Inflammation, Immunity and Cardiovascular Disease Travel Award
  • 2016 Center for Women’s Health Research National Conference Poster Award
  • 2016 American Heart Association BCVS New Investigator Travel Award

 

RECENT PUBLICATIONS

Refereed Journals

Bruns, D.R., Ehrlicher, S.E., Khademi, S., Biela, L.M., Peelor, F.F., Miller, B.F, Hamilton, K.L. (2018) “Differential effects of vitamin C and Protandim on skeletal muscle adaptation to exercise”. Journal of Applied Physiology.

Bruns, D.R. and Walker, L.A. (2017). “Exercise and pharmacology as medicine for CVD: from bench to beside and back.” Exercise and Sports Science Reviews.

Bruns, D.R., Ghincea, A.R., Ghincea, C.V., Autieri, M.V. Watson, P.A., Walker, L.A. (2017). “Interleukin-19 is cardioprotective in dominant negative CREB-mediated heart failure in a sexually dimorphic manner.” World Journal of Cardiology.

Bruns, D.R., Buttrick, P.M., Walker, L.A. (2016) “Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy.” AJP-Lung.

Bruns, D.R., Drake, J.C., Biela, L.M., Peelor, F.F., Miller, B.F., Hamilton, K.L. (2015). “Nrf2 signaling and the slowed aging phenotype: Evidence from long-lived models.” Oxidative Medicine and Cellular Longevity.

Drake, J. C., Bruns, D.R., Peelor, F.F. 3rd, Biela, L.M., Miller, R.A., Miller, B.F., Hamilton, K.L. (2015). “Long-lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC1 activity”. Aging Cell.

Bruns, D.R., Brown, R.D., Stenmark, K.R., Buttrick, P.M., Walker, L.A (2014). “Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction”. AJP-Lung.

Drake, J.C., Bruns, D.R., Peelor, R.F., Biela, L.M., Miller, R.A., Hamilton, K.L., Miller, B.F (2014). “Long-lived crowded litter mice have an age-dependent increase in protein synthesis to DNA synthesis and mTORC1-substrate phosphorylation”. AJP-Endo.

Reuland, D. J., J. M. McCord, and K. L. Hamilton (2013). “The role of Nrf2 in the attenuation of cardiovascular disease”. Exercise and Sports Science Reviews.

Reuland, D.J., Khademi, S., Castle, C.J., Irwin, D.C., McCord, J. M., Miller, B.F., et al. (2012). “Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress”. Free Radic Biol Med.

Miller, B.F., Robinson, M.M., Reuland, D.J., Drake, J.C., Peelor, F.F., 3rd, Bruss, M. D., et al. (2012). “Calorie Restriction Does Not Increase Short-term or Long-term Protein Synthesis”. J Gerontol A Biol Sci Med Sci.

Donovan, E. L., McCord, J.M., Reuland, D.J., Miller, B.F., & Hamilton, K.L. (2012). “Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge”. Oxid Med Cell Longev.

 

Book Chapters

Bruns, D.R., Walker, L.A. “Mitochondria and metabolism in right heart failure.” (in press). InTechOpen.

NATIONAL AND INTERNATIONAL PRESENTATIONS

2018 “Pulmonary hypertension-induced right ventricular pressure overload simulates cardiac fibroblast periostin expression and dedifferentiation of adult cardiac myocytes”. American Heart Association Scientific Sessions. Chicago, IL.

2018 “Novel and direct myofilament-mediated action of metformin in the aging right heart”. Gerontological Society of America Annual Scientific Meeting. Boston, MA.

2018 “Therapeutic activation of AMPK for the aging right heart.” Cardiology Research Conference. University of Colorado-Denver. Aurora, CO.

2017 “Novel mechanisms of right heart failure”. Colorado State University, Department of Health and Exercise Science Seminar Series.

2016 “Pulmonary hypertension-induced right ventricular pressure overload triggers acute epigenetic reprogramming of pro-inflammatory cardiac fibroblasts”. American Heart Association Scientific Sessions. New Orleans, LA.

2016 “Interleukin-19: A novel sexually dimorphic cardiac cytokine.” American Physiological Society Inflammation, Immunity, and Cardiovascular Diseases. Westminster, CO.

2016 “The epigenetically modified pro-inflammatory cardiac fibroblast drives cardiomyocyte dysfunction in pulmonary hypertension-induced right ventricular pressure overload”. Cardiology Research Conference. University of Colorado-Denver. Aurora, CO.

2015 “Molecular mechanisms regulating cardiac dysfunction in hypobaric hypoxia-induced RV pressure overload”. Cardiology Research Conference. University of Colorado-Denver. Aurora, CO.


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