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MSE Program

Physical Science Bldg. 210

Department 3905

1000 E. University Ave.

Laramie, WY 82071

Phone: 307.766.2862

Fax: 307.766.2652

Email: mse@uwyo.edu

Imaging and manipulating biological systems with optical sources

May 2, 2018

Date: Wednesday, May 2

Time: 12pm

Location: CR 314

Speaker: Jeff Squier, Department of Physics, Colorado School of Mines

Title of Talk: Imaging and manipulating biological systems with optical sources

Imaging and manipulating biological systems with optical sources is desirable from the perspective of providing selective, noninvasive methods that enable quantitative assessment and the ability to potentially alter the system of interest with minimal perturbation. There are inherent challenges to optical tools that can achieve optimal application given the constraints of the biological system: scattering, tissue differences, time scales of the event relative to the procedure being performed, to name a few. Significantly, the ultrafast optical community has made tremendous strides in advancing the application of femtosecond laser sources to meet these challenges. Here, we will show how large focal volumes which translates to large working distances, convenient for biology, can lead to gains in both imaging and manipulation without sacrificing resolution, and can be made compatible with scattering media. This is achieved through careful simultaneous spatial and temporal control of the focal volume (four-dimensional focusing) and spatial amplitude and/or phase modulation of the excitation source. Significantly, these methods that enable enhanced resolution past classical limits are straightforward to implement. Indeed, pragmatic application of these methods is an important consideration and will be presented.


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MSE Program

Physical Science Bldg. 210

Department 3905

1000 E. University Ave.

Laramie, WY 82071

Phone: 307.766.2862

Fax: 307.766.2652

Email: mse@uwyo.edu

1000 E. University Ave. Laramie, WY 82071
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