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Molecular Biology

Department of Molecular Biology
University of Wyoming
1000 E. University Ave.
Laramie, WY 82071

Email: DLJarvis@uwyo.edu

Phone: (307) 766-4282


Department of Molecular Biology

College of Agriculture and Natural Resources

Jarvis Lab: Publications (last five years):

Jarvis Quick Links

Publications (last five years):
  1. Aumiller, J.J., Mabashi-Asazuma, H., Hillar, A., Shi, X., and
Jarvis, D.L. 2012. A new glycoengineered insect cell line with an inducibly-mammalianized protein N-glycosylation pathway. Glycobiology 22:417-428.
  2. Teulé, F., Miao, Y., Sohn, B.-H., Kim, Y.-S., Hull, J.J., Fraser, M.J., Lewis, R.V. and Jarvis, D.L. 2012. Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties. Proc. Natl. Acad. Sci. U.S.A. 109:923-928.
  3. Geisler, C. and Jarvis, D.L. 2012. Substrate specificities and intracellular distributions of three N-glycan processing enzymes functioning at a key branch point in the insect N-glycosylation pathway. J. Biol. Chem. 287:7084-7097.
  4. Geisler, C., Kotu, V., Sharrow, M., Rendic, D., Poltl, G., Tiemeyer, M., Wilson, I.B.H., and Jarvis, D.L. 2012. The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter. J. Biol. Chem. 287:29599-29609.
  5. Geisler, C. and Jarvis, D.L. 2012. Innovative use of a bacterial enzyme involved in sialic acid degradation to initiate sialic acid biosynthesis in glycoengineered insect cells. Metabol. Engr. 14:642-652.
  6. Mabashi-Asazuma, 
Shi, X., Geisler, C., Kuo, C.-W., Kay-Hooi Khoo, K.-H., and 
Jarvis, D.L. 2013. Impact of a human CMP-sialic acid transporter on recombinant glycoprotein sialylation in glycoengineered insect cells. Glycobiology 23:199-210.
  7. Phillips, A.T., Stauft, C.B., Aboellail, T.A., Toth, A.M., Jarvis, D.L., Powers, A.M., and Olson, K.E. 2013. Bioluminescent imaging and histopathologic characterization of WEEV neuroinvasion in outbred CD-1 mice. PLoS One 8:e53462.
  8. Lin, C.-H. and Jarvis, D.L. 2013. Utility of temporally distinct baculovirus promoters for constitutive and baculovirus-inducible transgene expression in transformed insect cells. J. Biotechnol. 165:11-17.
  9. Serena, M.S., Geisler, C., Metz, G.E., Corva, S.G., Mórtola, E.C., Jarvis, D.L., Echeverría, M.G. 2013. Expression and purification of Suid Herpesvirus-1 glycoprotein E in the baculovirus system and its use to diagnose Aujeszky’s disease in infected pigs. Prot. Expr. Purif., 90:1-8.
  10. Gao, Y., Aryal, R.P., Ju, T., Cummings, R.D., Gahlay, G., Jarvis, D.L., Matta, K.L., Vlahakis, J.Z., Szarek, W.A., and Brockhausen, I. 2013. Acceptor specificities and selective inhibition of recombinant human Gal- and GlcNAc-transferases that synthesize core structures 1, 2, 3 and 4 of O-glycans. Biochim. Biophys. Acta, 1830:4274-4281.
  11. Gerken, T.A., Revoredo, L., Thome, J., Tabak, L.A., Clausen, H., Vester-Christensen, M.B., 
Jarvis, D.L., Gahlay, G.K., and Moremen, K.W. 2013. The lectin domain of the polypeptide GalNAc transferase family of glycosyltransferases (ppGalNAc T’s) acts as a switch directing glycopeptide substrate glycosylation in an N- or C- direction further controlling mucin-type O-glycosylation. J. Biol. Chem. 288:19900-19914.
  12. An, Y., Rininger, J.A., Jarvis, D.L., Jing, X., Ye, Z., Aumiller, J.J., Eichelberger, M., and Cipollo, J.F. 2013. Comparative glycomics analysis of influenza hemagglutinin (H5N1) produced in vaccine-relevant cell platforms. J. Proteome Res. 12:3707-3720.
  13. Lin, C.-H., Kuo, C.-W., Jarvis, D.L., and Khoo, K.-H. 2013. Facile removal of high mannose structures prior to extracting complex type N-glycans from de-N-glycosylated peptides retained by C18 solid phase to allow more efficient glycomic mapping. Proteomics 14:87-92. PMC3926941.
  14. Phillips, A.T., Schountz, T., Toth, A.M., Rico, A.B., Jarvis, D.L., Powers, A.M., and Olson, K.E. 2013. Liposome-antigen-nucleic acid complexes protect mice from lethal challenge with Western and Eastern equine encephalitis viruses. J. Virol. 88:1771-1780. PMC3911585
  15. Jarvis, D.L. 2014. Recombinant Protein Expression in Baculovirus-Infected Insect Cells. Meth. Enzymol. 536:149-163. PMC in process.
  16. Mabashi-Asazuma, 
H., Kuo, C.-W., Khoo, K.-H. and 
Jarvis, D.L. 2014. A novel baculovirus vector for the production of non-fucosylated recombinant glycoproteins in insect cells. Glycobiology 24:325-340. PMC3919471.
  17. Toth, A.M., Kuo, C.-W., Khoo, K.-H., and Jarvis, D.L. 2014. A new insect cell glycoengineering approach provides baculovirus-inducible glycogene expression and increases human-type glycosylation efficiency. J. Biotechnol. 182-183:19-29. PMC4095979.
  18. Harrison, R.L. and Jarvis, D.L. 2015. Transforming lepidopteran insect cells for continuous recombinant protein expression. Meth. Mol. Biol., Meth. Mol. Biol., in press 03/06/15.
  19. Harrison, R.L. and Jarvis, D.L. 2015. Transforming lepidopteran insect cells for improved protein processing. Meth. Mol. Biol., Meth. Mol. Biol., in press 03/06/15.
  20. Geisler, C., Mabashi-Asazuma, 
H., Kuo, C.-W., Khoo, K.-H. and Jarvis, D.L. 2015. Engineering ß1,4-galactosyltransferase I to reduce secretion and enhance N-glycan elongation in insect cells. J. Biotechnol. 193:52-65. PMC4278940.
  21. Maghodia, 
A., Jarvis, D.L., and Geisler, C. 2014. Complete genome sequence of the Autographa californica multiple nucleopolyhedrovirus strain E2. Genome Announc. 2:e01202-01214. PMC4263824.
  22. Geisler, C., Mabashi-Asazuma, H., and Jarvis, D.L. 2015. An overview and history of glycoengineering in insect expression systems. Meth. Mol. Biol. 1321:131-152.
  23. Mabashi-Asazuma, 
H., Sohn, B.-H., Kim, Y.-S., Kuo, C.-W., Khoo, K.-H., Kucharski, C.A., Fraser, M.J., and 
Jarvis, D.L. 2015. Targeted glycoengineering extends the protein N-glycosylation pathway in the silkworm silk gland. Insect Biochem. Mol. Biol. 65:20-27. PMC in process.
  24. Mabashi-Asazuma, 
H., Kuo, C.-W., Khoo, K.-H. and 
Jarvis, D.L. 2015. Modifying an insect cell N-glycan processing pathway using CRISPR-Cas technology. ACS Chem. Biol., August 13, 2015, epub ahead of print.
  25. Czuchry, D., Desormeaux, P., Stuart, M., Jarvis, D.L., Matta, K., Szarek, W.A., and Brockhausen, I. 2015. Synthesis of the sialyl-T antigen: Biochemical characterization of a novel α,3-sialyltransferase WbwA from pathogenic Escherichia coli serotype O104 and comparison to human ST3GAL1. J. Bacteriol., 197:3760-3768. PMC4652054.
  26. Revoredo, L., Clausen, H, Moremen, K.W., Jarvis, D.L., Ten Hagen, K.G., Tabak, L.A., and Gerken, T.A. 2015. Mucin type O-glycosylation is controlled and ordered by short and long range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase (ppGalNAc-T) family. Glycobiology 26:360-376. PMC4767052.
  27. Maghodia, A.B., Geisler, C., and Jarvis, D.L. 2016. Characterization of an Sf-rhabdovirus-negative S. frugiperda cell line as an alternative host for recombinant protein production in the baculovirus-insect cell system. Prot. Expr. Purif. 122:45-55. PMC4842140.
  28. Geisler, C. and Jarvis, D.L. 2016. Rhabdovirus-like endogenous viral elements in the genome of Spodoptera frugiperda insect cells are actively transcribed: implications for adventitious virus detection. Biologics 44:219-225. PMC4939140.
  29. Rico, A. Phillips, A.T., Schountz, T, Jarvis, D.L., Tjalkens, R.B., Powers, A.M. and Olson, K.E. 2016. Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses. Virology, in press.
  30. Jarvis, D.L., Maghodia, A.B., and Geisler, C. 2016. Assessing and addressing the risks associated with Sf-rhabdovirus, an adventitious agent in the baculovirus-insect cell system. Am. Pharm. Rev. 19:74-77.

(Last update 9/14/16)


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