Graduate Neuroscience Program
1000 East University Ave.
Laramie, WY 82071
Phone: (307) 766-6446
Fax: (307) 766-5625
All of your microscopic imaging and training needs can be met at the Microscopy Facility. The Microscopy Core is supported by the Neuroscience Center Core Grant from the National Institutes of Health (P30 RR32128). The objective of the Microscopy Core is to meet the growing imaging needs of the Neuroscience Center investigators who rely on the microscopy imaging to identify the structural bases that occur in neurons and their synapses in response to a variety of physiological events, development, and several neurodegenerative diseases.
Since its establishment, the Facility has grown in terms of instrumentation and service. The Microscopy Facility has four main components: epi fluorescence and bright field microscopy, confocal laser scanning microscopy, transmission electron microscopy, and scanning electron microscopy. The TEM is equipped with a high resolution (4000 X 4000) cooled CCD camera. With its capabilities, the Microscopy Core is essential to the NIH-funded projects of the Neuroscience Center investigators.
The Microscopy Core is maintained by a Director, Dr. Zhaojie Zhang. Dr. Zhang is an expert in electron and light microscopy. He and an associate keep the facility current in terms of new imaging capabilities and instrumentation. Dr. Zhang teaches Confocal and Electron Microscopy Courses, and consults and provides training in the use of the various instruments in the facility. Images captured as part of course requirements often are used in students theses and dissertations.
A new analytic capability of the Microscopy Core is stereology. Stereologic methods allow the accurate quantification of anatomic or molecular markers in biologic structures. A key feature of stereology is that quantification methods are not biased. As a result, modern stereology has resulted in findings that have contradicted earlier work using non-stereologic methods.