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Hermann M. Schatzl
We are studying prion diseases. Prion diseases are infectious neurodegenerative disorders of man and animals. A unique feature is that the manifestation is sporadic,genetic, or acquired by infection. Although mostly rare in incidence, prion diseases have the potential to get transmitted within or between species, resulting in endemic and epidemic scenarios. Whereas BSE has impressively demonstrated zoonotic potential,this is still open for CWD. Prion diseases can be controlled, but eradication is unlikely. Therefore, it is mandatory to understand the molecular and cellular requirements for propagation and transmission of prions, to device molecular strategies for controlling,and in the long-term to establish means for effectively assisting infected beings. The long-term goal of our group is to develop therapeutic and prophylactic anti-prion strategies, which finally can be used in vivo. The overall objective we have is to study the cellular and molecular biology of prion infections and to use gained understanding for delineating novel targets for intervention. Overall, our studies will provide new molecular insights and novel avenues for therapy against prion and protein misfolding disorders.
Positions and Employment
1995-2002 Group Leader, Max von Pettenkofer-Institute for Virology, University of Munich, Germany
1997-2002 Senior Scientist and Principal Investigator, Gene Center Munich, Germany
2002-2010 Professor of Clinical Virology and Head of Clinical Virology Section, Technical University of Munich
2006-2007 Director (prov.) of the Institute of Virology, Technical University of Munich, Germany
2010- Wyoming Excellence Chair in Prion Biology, University of Wyoming, Laramie, U.S.A.