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University of Wyoming
Mita Das, Ph.D.

Mita Das, Ph.D.
Associate Professor
Ph.D.
mdas@uwyo.edu • (307) 766-6129 • HS 498
Best Mode of Communication: E-mail

 

ACADEMIC TRAINING

1976-1980, BS in Chemistry, University of Calcutta, India.

1980-1982, MS in Biochemistry, University of Calcutta, India.

1982-1990, PhD in Biochemistry, University of Calcutta, India.

1990-1993, Postdoctoral Fellow, University of Arkansas for Medical Sciences, Little Rock, AR.

1993-1997, Postdoctoral Fellow, University of Colorado Denver, Denver, CO.


PROFESSIONAL EXPERIENCE


1997-2001, Instructor, University of Colorado Denver, Denver, CO, Department of Pediatrics, Division of Pediatric Critical Care.

2001-2008, Assistant Professor, University of Colorado Denver, Denver, CO, Department of Pediatrics, Division of Pediatric Critical Care.

2008-present, Associate Professor, University of Wyoming, Laramie, WY, School of Pharmacy.
 

AWARDS

1991, Excellence in Research, American Association of Physicians, Seattle, WA.

1996, Fellowship Award from Colorado, Wyoming and Arizona Heart Association.

1998, Giles Filley Memorial Award from American Physiological Society.
 
 

Research Interests:
Molecular signaling mechanisms for proliferative responses, differentiation and migration of vascular and tumor cells under hypoxic conditions

 

Teaching:
Medicinal Chemistry

 

Publications:

Book Chapters and Reviews

Stenmark KR, Davie N, Frid M, Gerasimovskaya E, Das M. Role of the adventitia in pulmonary vascular remodeling. 2006 Physiology 21, 134-145.

Zawada WM, Das M. Effects of alcohol on cell cycle of neural stem cells. In "Development of the Central Nervous System: Effects of Alcohol and Nicotine". Editor: Michael Miller, Oxford University Press, 2005, 199-215.

Stenmark KR, Gerasimovskaya E, Das M. Hypoxic activation of adventitial fibroblasts: Role in vascular remodeling. 2002 Chest, 122, 326S-334S.

Stenmark KR, Bouchey D, Nemenoff R, Dempsey EC, Das M. Hypoxia-induced pulmonary vascular remodeling: Contribution of the adventitial fibroblasts. 2000 Physiol Res. 49, 503-517.

Stenmark KR, Das M, Bouchey DM, Dempsey EC. Contribution of the adventitial fibroblasts to vascular disease. 1999 In: Reeves, J. T. and Weir, E. K., eds: Development of the Pulmonary Circulation, Futura Publishing, Armonk, N.Y. Chapter 5, 67-86.

Stenmark KR, Frid M, Nemenoff R, Dempsey EC, Das M. Hypoxia induces cell –specific changes in gene expression in vascular wall cells: Implications for pulmonary hypertension. 1999 Adv. Exp. Med. Biol. 474, 231-258.

Peer-reviewed Papers

Shields KM, Burns N, West J, Zawada WM, Das M. Lack of hypoxia-induced upregulation of vascular endothelial growth factor expression leads to vessel loss in the lungs of mitogen-activated protein kinase phosphatase-1 deficient mice. 2008, Circulation Res. Submitted.

Ahmadi FA, Grammatopoulos TN, Poczobutt AM, Jones SM, Snell LD, Das M, Zawada WM. Dopamine selectively sensitizes dopaminergic neurons to rotenone-induced apoptosis. 2008, Neurochem Res 33, 886-901.

Das M, Burns N, Wilson SJ, Zawada WM, Stenmark KR. Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKC in the pulmonary artery adventitia. 2008, Cardiovasc Res. 78(3), 440-448.

Okamoto M, Poczobutt AM, Zawada WM, Das M. PKC-driven midkine acts as an autocrine factor for the growth of human non-small lung cancer cells selectively under hypoxic conditions. 2008, Cancer Res. Submitted.

Short MD, Fox SM, Lam CF, Stenmark KR, Das M. PKC attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression. 2006 Mol Biol Cell 17, 1995-2008.

Short M, Nemenoff R, Zawada WM, Stenmark KR, Das M. Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts. 2004 Am J Physiol 286, C416-C425.

Das M, Dempsey EC, Reeves JT, Stenmark KR. Selective expansion of specific fibroblast subsets in the adventitia during the development of hypoxic pulmonary hypertension. 2002 Am J Physiol 282, L976-L986.

Das M, Bouchey DM, Moore M, Hopkins D, Nemenoff R, Stenmark KR. Hypoxia-induced proliferative responses of pulmonary artery adventitial fibroblasts is dependent on G-protein mediated activation of MAP kinases. 2001 J Biol Chem 276, 15631-15640.

Das M, Dempsey EC, Bouchey D, Reyland ME, Stenmark KR. Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: Potential contribution of specific PKC isozymes. 2000 Am J Respir Cell and Mol Biol. 22, 15-25.

Dempsey EC, Frid MG, Aldashev AA, Das M, Stenmark KR. Heterogeneity in the proliferative response of bovine pulmonary artery smooth muscle cells to mitogens and hypoxia: Importance of protein kinase C. 1997 Canad J Physiol and Pharm. 75, 936-944.

Xu Y, Stenmark KR, Das M, Walchak SJ, Ruff LJ, Dempsey EC. Pulmonary artery smooth muscle cells from hypoxic calves retain fetal-like and acquire new growth properties. 1997 Am J Physiol 273, L234-L245.

Dempsey EC, Das M, Frid M, Stenmark KR. Unique growth properties of neonatal pulmonary artery vascular cells: Importance of time and site-specific responses, cell-cell interaction, and synergy. 1996 J Perinatol. 16, S2-11.

Das M, Stenmark KR, Dempsey EC. Enhanced growth of fetal and neonatal pulmonary artery adventitial fibroblasts is dependent on protein kinase C. 1995 Am J Physiol 269, L660-L667.

Lipschitz DA, Udupa KB, Indelicato SR, Das M. Effect of age on second messenger generation in neutrophils. 1991 Blood. 78, 1347-1354.

Sengupta T, Chattopadhyay D, Ghosh N, Das M, Chatterjee GC. Effect of chromium adminstration on glutathione cycle of rat epithelial cells. 1990 Indian J Exp Biol. 28, 1132-1135.

Das M, Chatterjee GC. Differential response of cadmium toxicity towards Mg2+-ATPase activity in hepatic and renal nuclear membrane in rats. 1990 Indian J Biochem Biophys. 27, 172-175.

Ghosh N, Mukhopadhyay S, Chattopadhyay D, Das M, Addya S, Chatterjee GC. Effects of methionine supplementation on lanthanum chloride and neodymium chloride induced alterations in enzymes of the antioxidant defence system and gamma-glutamyl cycle in chick liver. 1988 Indian J Biochem Biophys. 25, 336-340.

Das M, Ghosh N, Chattopadhyay D, Addya S, Chatterjee GC. Effects of acute oral administration of cadmium chloride on uptake of element and control of lipoperoxidative process in hepatic and renal nuclear fractions of rats. 1988 Indian J Exp Biol. 26, 449-452.

Das M, Mukhopadhyay S, Addya S, Chakravarti K, Chatterjee GC. Effects of in vivo cadmium admintration to rats on certain functional parameters of isolated erythrocytes. 1987 Indian J Exp Biol. 25, 244-248.

Addya S, Chakravarti K, Das M, Ghosh N, Chakravarti D, Chatterjee GC. Effects of mercuric chloride on antioxidant defence components of rat erythrocyte and plasma: influence of vitamin E supplementation. 1986 Indian J Exp Biol. 24, 468-470.

 

Affiliations, Associations, Consultation:

American Heart Association

American Physiological Society

American Society for Cell Biology
 
 

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