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University of Wyoming
Sreejayan Nair, Ph.D.

Sreejayan Nair, Ph.D.
Director, Center for Cardiovascular Research and Alternative Medicine (C-CRAM)
Associate Professor Pharmacology

Ph.D.
sreejay@uwyo.edu • (307)766-6138 • HS 279
Best Mode of Communication: E-mail

 

Education:

B. Pharm. 1989, College of Pharmaceutical Sciences, Manipal, Mangalore University, India

M. Pharm. 1991, College of Pharmaceutical Sciences, Manipal, Mangalore University, India

Ph.D. 1996, College of Pharmaceutical Sciences, Manipal, Mangalore University, India

Professional experience:
2002-present
Assistant Professor, University of Wyoming, School of Pharmacy, Laramie, Wyoming

1998-2002
Post Doctoral Fellow, Department of Physiology, University of Tennessee, Memphis, Tennessee

1996-1998
Research Fellow, Department of Medicine II, Klinikum Grosshadern, Ludwig Maximillians University, Munich, Germany

1994-1996
Assistant Professor, Department of Pharmaceutical Chemistry College of Pharmaceutical Sciences, Manipal, India

Research:
My laboratory is interested in studying insulin and insulin-like growth factor (IGF-1)-mediated signal transduction in neuronal cells. Our long-range goal is to identify the role of insulin and IGF1 in neurodegenerative disorders. Our hypothesis is that impaired insulin and IGF-1 signaling leads to impairment of neuronal functions associated with neurodegenerative diseases. We use the general techniques of cell biology such as tissue culture, Western blotting, immunoprecipitation, immunocytochemistry and the techniques of molecular biology, including the use of adenoviral vectors for transgene expression and knock-out animals. Outcome of our studies will help in understanding the mechanisms involved in the pathogenesis of neurodegenerative disorders and may aid in developing novel therapeutic strategies to treat or prevent these conditions. 





 
 

Research Interests:
Diabetes, Cardiovascular Disease

 

Teaching:
Pharmacology/Toxicology/Molecular and Cellular Basis of Diseases

 

Publications:

Peer Reviewed Journal Articles

Dong F, Hua Y, Zhao P, Ren J, Du M, Sreejayan N. (2009) Chromium Supplement Inhibits Skeletal Muscle Atrophy in Hindlimb Suspended Mice. Journal of Nutritional Biochemistry, in press.

Zhao P, Wang J, Ma H, Xiao Y, He L, Tong C, Wang Z, Zeng Q, Dolence EK, Sreejayan N, Ren J, Li J. (2009) A newly synthetic chromium complex-chromium (D-phenylalanine)3 activates AMP-activated protein kinase and stimulates glucose transport. Biochemical Pharmacology 77: 1002-10.

Jüngst C, Sreejayan N, Zündt B, Muller I, Spelsberg FW, Hutt TP, Kullak-Ublick GA, del Pozo R, Jüngst D, von Ritter C. (2008) Ursodeoxycholic acid reduces lipid peroxidation and mucin secretagogue activity in gallbladder bile of patients with cholesterol gallstones. European Journal of Clinical Investigation, 38: 634-639.

Sreejayan N, Yang X, Palanichamy K, Dolence K, Ren J. (2008) Antioxidant properties of argpyrimidine. European Journal of Pharmacology, 593: 30-5.

Liu Y, Dolence J, Ren J, Rao M, Sreejayan N. (2008) Inhibitory effect of dehydrozingerone on vascular smooth muscle cell function. Journal of Cardiovascular Pharmacology, 52: 422-9.

Ren J, Duan JH, Thomas DP, Yang XP, Sreejayan N, Sowers JR, Leri A, Kajstura J, Gao F, Anversa P. (2008) IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 294: R793-R802.

Dong F, Kandadi MR, Ren J, Sreejayan N. (2008) Chromium (D-phenylalanine)3 supplementation alters glucose disposal, insulin signaling, and glucose transporter-4 membrane translocation in insulin-resistant mice. Journal of Nutrition, 138: 1846-51.

Sreejayan N, Dong F, Kandadi MR, Yang XP, Ren J. (2008) Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice. Obesity, 16: 1331-1337.

Fang CX, Yang XP, Sreejayan N, Ren J. (2007) Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells. Experimental Neurology, 203: 196-204.

Dong F, Li Q, Sreejayan N, Nunn JM, Ren J. (2007) Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis. Diabetes, 56: 2201-12.

Jungst C, Sreejayan N, Eder MI, von Stillfried N, Zundt B, Spelsberg FW, Kullak-Ublick GA, Jungst D, von Ritter C. (2007) Lipid peroxidation and mucin secretagogue activity in bile of gallstone patients. European Journal of Clinical Investigation, 37: 731-736.

Dong F, Yang XP, Sreejayan N, Ren J. (2007) Chromium(D-phenylalanine)3 improves obesity-induced cardiac contractile defect in ob/ob mice. Obesity, 15: 2699-2711.

Li Q, Yang X, Sreejayan N, Ren J. (2007) Insulin-like growth factor I deficiency prolongs survival and antagonizes paraquat-induced cardiomyocyte dysfunction: role of oxidative stress. Rejuvenation Research, 10: 501-12.

Stratton MS, Yang X, Sreejayan N, Ren J. (2007) Impact of insulin-like growth factor-I on migration, proliferation and Akt-ERK signaling in early and late-passages of vascular smooth muscle cells. Cardiovascular Toxicology, 7: 273-81.

Sreejayan N, Yang X. (2007) Isolation and functional studies of rat aortic smooth muscle cells. Methods in Molecular Medicine, 139: 283-92.

REFEREED CHAPTERS IN BOOKS

Li S-Y & Ren J. Assessment of Protein Glycoxidation in Ventricular Tissues. In: Methods in Molecular Biology Book Series. Ed: Ren J & Sreejayan, 1st ed. The Humana Press Inc., Totowa, New Jersey, USA, 2006. (In press)

Devasagayam TPA, Sreejayan N, Curcumin as Antioxidant. In: Micronutrients and Health: Molecular Biological Mechanisms. Eds: Nesaretnam K, Packer, L., pp 42-59, 2001, AOCS Press, IL

Sreejayan N, von Ritter R. Bile acids and lipid peroxidation. Advances in DNA damage and repair. Dizdaroglu M; Ed., p 471-472, 1999, Kluwer Academic Press, The Netherlands.

REFEREED JOURNAL ARTICLES

Li SY, Yang X, Ceylan-Isik AF, Du M, Sreejayan N, Ren J (2006) Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca(2+)-ATPase and myosin heavy chain isozyme switch. Dibetologia 49:1434-46

Wold LE, Ceylan-Isik AF, Fang CX, Yang X, Li SY, Sreejayan N, Privratsky JR, Ren J. (2006) Metallothionein Alleviates Cardiac Dysfunction in Streptozotocin-Induced Diabetes: Role of Ca2+ Cycling Proteins, NADPH Oxidase, Poly(ADP-Ribose) Polymerase and Myosin Heavy Chain Isozyme, Free Rad.. Biol. Med. 40: 1419-29

Fang CX, Yang X, Sreejayan N, Ren J. (2006) Acetaldehyde Promotes Rapamycin-Dependent Activation of p70S6K and Glucose Uptake Despite Inhibition of Akt and mTOR in Dopaminergic SH-SY5Y Human Neuroblastoma Cells. Experimental Neurology (in press)

Yang X, Li SY, Dong F, Ren J, Sreejayan N. Insulin sensitizing and cholesterol lowering effects of Chromium (D-Phenylalanine)3 J. Inorg. Biochem. 100: 1187-93

Yang X, Doser TA, Fang CX, Nunn J, Janardhanan R, Zhu M, Sreejayan N, Quinn M, Ren J. (2006) Metallothionein Prolongs Survival and Antagonizes Senescence-Associated Cardiomyocyte Diastolic Dysfunction: Role of Oxidative Stress. FASEB J. 20:1024-26

Yang, X, Thomas, DP, Zhang,X, Culver, BW, Alexander, BM, Murdoch, WJ, Rao, MN, Tulis, DA, Ren, J, Sreejayan, N. (2006) Curcumin Inhibits Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cell Function and Injury-Induced Neointima Formation. Arterioscler Thromb Vasc Biol. 26: 85-90.

Fang CX, Doser TA, Yang X, Sreejayan N, Ren J (2006) Metallothionein Antagonizes Aging-Induced Cardiac Contractile Dysfunction: Role of PTP1B, Insulin Receptor Tyrosine Phosphorylation and Akt. Aging Cell 5: 177-185.

Yang, X., Palanichamy, K., Ontko, A.C., Rao, M., CX, F., R, J., and Sreejayan, N. (2005) A newly synthetic chromium complex -chromium (phenylalanine)3 improves insulin responsiveness and reduces whole body glucose tolerance. FEBS Lett. 579: 1458-1464.

Yang, X, Zhu, MJ, Sreejayan, N, Ren J, Du, M (2005) Angiotensin II promotes smooth muscle cell proliferation and migration through release of heparin-binding epidermal growth factor and activation of EGF-receptor pathway. Mol Cells. 20: 263-70

Yang, X., Sreejayan, N and Ren (2005) Views from within and beyond: Narratives of cardiac contractile dysfunction under senescence Endocrine 26: 127-37

Li, SY, Du M, Dolence EK, Fang CX, Mayer GE, Ceylan-Isik AF, LaCour KH, Yang X, Wilbert CJ, Sreejayan N and Ren J (2005) Senescence induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification, Aging Cell 4: 57-64

Yigzaw Y, Popplet H.M., Sreejayan N, Hassid A, Patel TB (2003) Protein tyrosine phosphatase-1B (PTP-1B) mediates the anti-migratory actions of sprouty. J. Biol. Chem. 278: 284-88

Sreejayan N, Lin Y, Hassid A (2002) Nitric oxide attenuates insulin signaling and motility in aortic smooth muscle cells via a PTP1B mediated mechanism. Arterioscler/ Thromb. Vasc. Biol. 22:1086-92

Chang Y, Ceacareanu B, Dixit M, Sreejayan N, Hassid A (2002) Nitric oxide-induced motility in aortic smooth muscle cells: role of protein tyrosine phosphatase SHP-2 and GTP-binding protein Rho. Circulation Research. 91: 390-7.

Sreejayan N, Wittig BM, et.al., (2001) E-Selectin binding by human biliary mucin. Am J Physiol (Gastroenterol Liv Phys) 280: G1043-G1048

Wildhirt SM, Schulze C, Conrad N, Sreejayan N, von Rittter, C and Reichart, B (2000) Reduced myocardial damage and lipid peroxidation in off-pump versus conventional bypass. Eur J Med Res. 5: 222-228.

Sreejayan N, von Ritter C (1999) Lipid peroxidation in bile: Role of bile acids and the effect on biliary epithelial cell function. Pathophysiology 5: 225-232.

Ganesh Pai C, Sreejayan N, Rao MNA (1999) Oxidant stress in chronic pancreatitis. Ind J Gastroenterol 8: 156-7.

Sreejayan N, von Ritter C (1998) Effect of bile acids on lipid peroxidation: Role of iron. Free Rad Biol Med 25: 50-56.

Sreejayan N, Rao MNA, Devasagayam TPA (1997) Inhibition of radiation induced peroxidation by Curcumin. Int J Pharm 151: 127-130

Sreejayan N, Rao, MNA (1997) Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol. 49: 105-107.

Guha SN, Priyadarsini KI, Devasagayam, TPA, Sreejayan N, Rao MNA (1997) Hydroxyl radical reactions of 5-bromophenyl pentenone. Rad Phys Chem 49: 43-46.

Sreejayan N, Rao MNA (1996) Oxygen free radical scavenging by curcuminoids. Arzneim-Froschun /Drug Research. 2: 169-171.

Sreejayan N, Rao, MNA (1994) Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol 46: 1013-1016.

Subramanian M, Sreejayan N, Devasagayam TPA, Rao MNA (1994) Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants. Mutat Res. 311: 249-255.

Sreejayan N, Rao MNA (1993) Curcumin inhibits iron dependent lipid peroxidation. In J Pharm 100: 93-97.

Sreejayan N, Rao MNA (1991) Oxygen free radical scavenging by Momordica charantia extract. Fitoterapia LXII: 344-346

 

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