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School of Pharmacy|College of Health Sciences

Jun Ren, M.D., Ph.D., FAHA

Associate Dean for Research, College of Health Sciences

Wyoming INBRE Program Director

Professor of Pharmacology

jren@uwyo.edu • (307) 766-6131 • HS 594

Best Mode of Communication: Both e-mail and voicemail

Office Hours: M- F, 1:00 - 3:00 p.m.

Adjunct Professor, University of Washington, University North Dakota, Peking Union Medical College

Research Interests:

Cardiovascular and neurodegenerative diseases

Teaching:

Pharmacology, Clinical Toxicology, Molecular and Cellular Basis for Diseases

Publications:

REFEREED CHAPTERS IN BOOKS

Li S-Y & Ren J. Assessment of Protein Glycoxidation in Ventricular Tissues. In: Methods in Molecular Biology Book Series. Ed: Ren J & Sreejayan, 1st ed. The Humana Press Inc., Totowa, New Jersey, USA, 2006. (In press)

REFEREED JOURNAL ARTICLES

Yang, X, Thomas, DP, Zhang,X, Culver, BW, Alexander, BM, Murdoch, WJ, Rao, MN, Tulis, DA, Ren, J, Sreejayan, N. (2006) Curcumin Inhibits Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cell Function and Injury-Induced Neointima Formation. Arterioscler Thromb Vasc Biol. 26: 85-90.

Wold LE, Ceylan-Isik AF, Fang CX, Yang X, Li SY, Sreejayan N, Privratsky JR, Ren J. (2006) Metallothionein Alleviates Cardiac Dysfunction in Streptozotocin-Induced Diabetes: Role of Ca2+ Cycling Proteins, NADPH Oxidase, Poly(ADP-Ribose) Polymerase and Myosin Heavy Chain Isozyme, Free Rad.. Biol. Med. 40: 1419-29

Fang CX, Doser TA, Yang X, Sreejayan N, Ren J (2006) Metallothionein Antagonizes Aging-Induced Cardiac Contractile Dysfunction: Role of PTP1B, Insulin Receptor Tyrosine Phosphorylation and Akt. Aging Cell 5: 177-185.

Wold LE, Ceylan-Isik AF, Fang CX, Yang X, Li S-Y, Nair Sreejayan, Jamie R. Privratsky and Jun Ren. 2006. Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. Free Radical Biology & Medicine. 40: 1419-1429.

Yang X, Li S-Y, Dong F, Ren J, Sreejayan N. 2006. Insulin-sensitizing and cholesterol-lowering effects of chromium (d-Phenylalanine)(3). J Inorg Biochem. 100:1187-93.

Li S-Y, Yang X, Ceylan-Isik AF, Du M, Ren BH, Sreejayan N, Ren J. 2006. Cardiac contractile dysfunction in ob/ob obesity is accompanied with oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch. Diabetologia. 49:1434-46.

Fang CX, Yang X, Sreejayan N, Ren J. (2006) Acetaldehyde Promotes Rapamycin-Dependent Activation of p70S6K and Glucose Uptake Despite Inhibition of Akt and mTOR in Dopaminergic SH-SY5Y Human Neuroblastoma Cells. Experimental Neurology (in press)

Yang X, Li SY, Dong F, Ren J, Sreejayan N. Insulin sensitizing and cholesterol lowering effects of Chromium (D-Phenylalanine)3 J. Inorg. Biochem. 100: 1187-93

Yang X, Doser TA, Fang CX, Nunn J, Janardhanan R, Zhu M, Sreejayan N, Quinn M, Ren J. (2006) Metallothionein Prolongs Survival and Antagonizes Senescence-Associated Cardiomyocyte Diastolic Dysfunction: Role of Oxidative Stress. FASEB J. 20:1024-26

Xu P, Van Kirk EA, Li S-Y, Murdoch WJ, Ren J, Hussain MD, Radosz M, Shen Y. 2006. Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy. Colloids Surf B Biointerfaces. 48:50-7.

Li S-Y, Li Q, Shen J J, Dong F, Sigmon V K, Liu Y, Ren J. 2006. Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. J. Mol. Cell Cardiol. 40: 283-294.

Ceylan-Isik A F, Wu S, Li Q, Li S-Y, Ren J. 2006. High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus. J. Appl. Physiol. 100: 150-156.

Li S-Y, Xu P, Babcock SA., Brownlee M, Shen Y, Ren J, 2006. Advanced glycation endproduct (AGE) is linked to cardiomyocyte contractile dysfunction in streptozotocin-diabetic mouse Diabetes. (In review)

Li SY, Yang X, Ceylan-Isik AF, Du M, Sreejayan N, Ren J (2006) Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca(2+)-ATPase and myosin heavy chain isozyme switch. Dibetologia 49:1434-46

Li S-Y, Golden KL., Jiang Y, Graham C, Wang G-J, Privratsky JR, Zhang X, Eason AR, Culver B, Ren J. 2005. Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocyte from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins. Cell Biochem Biophys. 42: 1-12.

Yang, X., Sreejayan, N and Ren (2005) Views from within and beyond: Narratives of cardiac contractile dysfunction under senescence Endocrine 26: 127-37

Yang, X, Zhu, MJ, Sreejayan, N, Ren J, Du, M (2005) Angiotensin II promotes smooth muscle cell proliferation and migration through release of heparin-binding epidermal growth factor and activation of EGF-receptor pathway. Mol Cells. 20: 263-70

Li S-Y, Fang CX, Aberle NS II, Ren BH, Ceylan-Isik AF, Ren J. 2005. Inhibition of PI-3 kinase/Akt/mTOR but not calcineurin signaling reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function. J. Endocrinol. 186: 491-503.

Li S-Y, Du M, Dolence EK, Fang CX, Mayer GE, Ceylan-Isik AF, LaCour KH, Yang X, Wilbert CJ, Sreejayan N and Ren J. 2005. Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation Endproducts and protein modification. Aging Cell. 4: 57-64.

Li S-Y, Liu Y, Sigmon VK, McCort A, Ren J. 2005. High fat diet enhances advanced glycation endproduct (AGE) and apoptosis: role of nuclear O-GlcNAc modification and p38 MAP kinase activation. Diabetes, Obesity and Metabolism. 7: 448-54.

Dong F, Zhang X, Li S-Y, Zhang Z, Ren Q, Culver B, Ren J. 2005. Involvement of NADPH oxidase and JNK in homocysteine-induced oxidative stress and apoptosis in human umbilical vein endothelial cells. Cardiovasc. Toxicol. 5:9-20.

Li, SY, Du M, Dolence EK, Fang CX, Mayer GE, Ceylan-Isik AF, LaCour KH, Yang X, Wilbert CJ, Sreejayan N and Ren J (2005) Senescence induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification, Aging Cell 4: 57-64

Xu P, Tang H, Li S-Y, Ren J, Van Kirk E, Murdoch WJ, Radosz M, Shen Y. 2004. Enhanced stability of core-surface cross-linked micelles fabricated from amphiphilic brush copolymers. Biomacromolecules. 5:1736-44.

Zhang X, Li S-Y, Brown RA and Ren J. 2004. Alcohol and acetaldehyde in alcoholic cardiomyopathy- from bad to ugly en route to oxidative stress. Alcohol. 32:175-86.

Li S-Y, Gomelsky M, Duan J, Zhang Z, Gomelsky L, Zhang X, Epstein PN, Ren J. 2004. Overexpression of aldehyde dehydrogenase-2 transgen prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 MAP kinase. J. Biol Chem. 279:11244-11252.

Li S-Y, Culver B, Ren J. 2003. Benefit and risk of exercise on myocardial function in diabetes. Pharmacological Research. 48: 127-132.

Folden DV, Gupta A, Sharma AC, Li S-Y, Saari JT, Ren J. 2003. Malondialdehyde inhibits cardiac contractile function in ventricular myocytes via a p38 mitogen-activated protein kinase-dependent mechanism. Br. J. Pharmacol. 139:1310-1316.

Li S-Y, Gomelsky M, Duan J, Zhang Z, Gomelsky L, Zhang X, Epstein PN, Ren J. 2003. Over-expression of aldehyde dehydrogenase-2 transgen attenuates acetaldehyde-induced apoptosis in human umbilical vein endothelial cells: role of ERK and p38 MAP kinase. Circulation (Supl.). 108 (17): IV-286.

Service:

Graduate & PharmD Advising Committee

Affiliations, Associations, Consultation:

American Heart Association, American Diabetes Association

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Jun Ren, M.D., Ph.D., FAHA

Jun Ren, M.D., Ph.D., FAHA, College of Health Sciences Associate Dean for Research and Wyoming INBRE Program Director

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