Xihui Xu, M.D., Ph.D., M.S.
Programmed cell death has been shown to play a pivotal role in the maintenance of life. Within the programmed cell death, autophagy is an evolutionarily conserved cellular pathway governing long-lived protein and cytoplasmic organelles degradation and recycling. My research interest is focused on exploring the role of autophagy in different diseases, including cardiovascular disease, neurodegenerative disease and liver disease. Additionally, I also have interest in understanding the role of stem cell in the development of different diseases, such as aging. I have published several papers on understanding the role of autophagy in the maintenance of cardiac homeostasis and liver function under different pathological conditions.
Positions and Honors:
2010- 2011, Graduate student members of the UW Graduate Council
2011, CHS Student Research Seed Grant; Grand Rounds Research Day Student Travel Award, College of Health Science, Laramie WY; Graduate Student Travel Award, University of Wyoming, Laramie WY
2012, Grand Rounds Research Day Third Place Student Poster, College of Health Science, Laramie, WY
2012, ACRE-CnAHA symposium award
2012, 2012 BCVS Abstract Travel Grant (AHA)
2013, 2013 BCVS Abstract Travel Grant (AHA)
Other Experience and Professional Memberships:
2011- Current, American Heart Association
04-20-2011, Moderator for Wyoming Undergraduate Research Day
04-26-2013, Moderator for Wyoming Undergraduate Research Day
1. Xu XH, Zhang HL, Han R, Gu ZL, Qin ZH. Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia. Brain Res. 2006; 1102(1):154-62.
2. Xu XH, Hua YN, Zhang HL, Wu JC, Miao YZ, Han R, Gu ZL, Qin ZH. Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. Acta Pharmacol Sin; 2007; 28(8):1097-104.
3. Flynn FW, Jensen DD, Thakar A, Xu X, Flynn SW, Zhang Z. Neurokinin 3 receptor forms a complex with acetylated histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R822-31.
4. Xu X, Ren J. Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction. Clin Exp Pharmacol Physiol. 2012; 39(2):200-8.
5. Xu X, Hua Y, Sreejayan N, Zhang Y, Ren J. Akt2 Knockout Preserves Cardiac Function in High Fat Diet-Induced Obesity by Rescuing Cardiac Autophagosome Maturation. J Mol Cell Biol, 2013; 5(1):61-3.
6. Xu X, Ren J. Cardiac stem cell regeneration under metabolic sundrome. Curr Pharm Des, 2013.
7. Xu X, Lindsay K. Hueckstaedt, Jun Ren. Deficiency of Insulin-Like Growth Factor 1 Attenuates Aging-Induced Changes in Hepatic Function: Role of Autophagy. J Hepatol. 2013; 10.
8. Xu X, Benjamin D. Pacheco, Ling Leng, Richard Bucala, Jun Ren. Macrophage Migration Inhibitory Factor Plays a Permissive Role in the Maintenance of Cardiac Contractile Function under Starvation through Regulation of Autophagy. Cardiovasc Res, 2013; 13.
9. Hua Y, Xu X, Shi GP, Chicco AJ, Ren J, Nair S. Cathepsin K Knockout Alleviates Pressure Overload-Induced Cardiac Hypertrophy. Hypertension, 2013; 61(6): 1184- 92.
10. Zhang Y, Xu X, Ren J. mTOR overactivation and interrupted autophagy flux in obese hearts: a dicey assembly. Autophagy, 2013; 9 (6): 939- 41.
11. Dong M, Hu N, Hua H, Xu X, Kandadi MR, Guo R, Jiang S, Nair N, Hu D, Ren J. Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress. Biochim Biophys Acta, 2013; 1832 (6): 848- 863.
12. Ceylan-Isik AF, Kandadi MR, Xu X, Hua Y, Chicco AJ, Ren J, Nair S. Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Cardiol, 2013; 63C: 4- 13.
1. Xu X, Zhang Y, Ren J. TRAF6 mediates the cardioprotective effect of lipopolysaccharide against insulin resistance in an AKT2 knockout murine model. AHA Winter Conference, Keystone, CO February 2011 (Poster)
2. Xu X, Hua Y, Zhang Y, Ren J. Akt2 knockout alleviates high-fat diet-induced cardiac dysfunction. Experimental Biology, Washington DC, April 2011 (Poster)
3. Xu X, Hua Y, Zhang Y, Nair S, Ren J. Reactivation of autophagic flux by Akt2 knockout is beneficial for cardiac function in high fat diet-induced obesity. Circulation 124:A13634, 2011. AHA meeting Presentation, Orlando, Nov 2011. (Oral)
4. Xu X, Hua Y, Nair S, Jun Ren. Cardiac Macrophage Migration Inhibitory Factor Activates Mitophagy to Prevent the Exacerbation of Pressure Overload-Induced Hypertrophic Cardiomyopathy in Mice. AHA meeting Presentation, Los Angeles, Nov 2011. (Oral)
5. Xu X and Jun Ren. Macrophage Migration Inhibitory Factor Knockout Exacerbates Doxorubicin-Induced Cardiomyopathy: Role of Autophagy. AHA meeting Presentation, Los Angeles, Nov 2012. (Poster)
6. Xu X, Roe ND, and Ren J. Inhibition of mTOR with rapamycin reverses cardiomyocyte-specific knockout of PTEN-induced hypertrophic cardiomyopathy. Third Biennial Western Regional IDeA Conference, Hawaii, Oct 2013. (Oral)
7. Xu X and Ren J. Macrophage Migration Inhibitory Factor Deficiency Exacerbates Aging-induced Cardiac Dysfunction in Mice: Role of Autophagy. AHA meeting Presentation, Dallas, Nov 2013. (Poster)
8. Xu X and Ren J. Macrophage Migration Inhibitory Factor Knockout Preserves Cardiac Function in High Fat Diet-Induced Metabolic Syndrome. AHA meeting Presentation, Dallas, Nov 2013. (Poster)
9. Xu X, Roe ND, Weiser-Evans MCM, and Ren J. Inhibition of mTOR with rapamycin reverses cardiomyocyte-specific knockout of PTEN-induced hypertrophic cardiomyopathy. AHA meeting Presentation, Dallas, Nov 2013. (Poster)
1. Regulation of Autophagy in Obesity-Induced Cardiac Dysfunction. Xihui Xu and J. Ren; Autophagy: Caner, Other Pathologies, Inflammation, Immunity, and Infection. (2013), Elsevier
Funding Agency: College of Health Science, University of Wyoming, 2011- 2012
Title: Role of MIF in Abdominal Aortic Constriction-Induced Autophagic Flux Change in Murine Heart
The goal of this study was to evaluate the role of macrophage migration inhibitory factor (MIF) in pressure overload-induced murine cardiac hypertrophy and its interaction with cardiac autophagy activity.
Address: 1000 E. University Ave., Laramie WY 82071
Extensive experience with: Microsurgeries, animal models of different disease models, echocardiography, DEXA, metabolic chamber, single cardiomyocyte function, histological assays, confocal, TEM.
Heart and Circulatory Physiology: American Journal of Physiology
Clinical and Experimental Pharmacology & Physiology
Cell Biochemistry and Biophics
Current Pharmaceutical Design
Journal of Molecular Endocrinology