Travis Brown Study Published in Hippocampus
Travis Brown, Ph.D., assistant professor of pharmaceutical science, recently had an article titled, "Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice," published in the neuroscience journal of Hippocampus.
TRPV1 receptors are multimodally activated channels classically characterized as the "capsaicin receptor." Recent studies have suggested that TRPV1-like receptors are functionally expressed in the brain. To further elucidate what role TRPV1 receptors may have in brain function, Brown, in conjunction with Anda Chirila, Benjamin Schrank and Dr. Julie Kauer (Professor, Brown University), recently showed that TRPV1 and TRPV3 receptors both regulate synaptic efficacy in the hippocampus, a brain region implicated in learning and memory. This may open up new therapeutic targets for memory, addiction, epilepsy and pain.