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University Catalog|Office of the Registrar

Molecular Biology (MOLB)

1000 Level | 2000 Level | 3000 Level | 4000 Level | 5000 Level

USP Codes are listed in brackets by the 1991 USP code followed by the 2003 USP code (e.g. [M2<>QB]).

1010. Science and Society. 1. [(none)<>I, L] Topics which involve the interface of molecular biology with societal issues, such as AIDS, genetic screening and recreational drugs, will be presented by faculty from the molecular biology department and other departments. After these presentations, students will discuss the issues in a debate format. Grading will be based on attendance as well as participation in discussions.

2021 [2210]. General Microbiology. 4. Introduces nature and diversity of microorganisms and their implication for all of biology. Covers comparative properties of eukaryotic and prokaryotic microbes, as well as their roles as disease agents, ecological agents, and model systems for understanding of fundamental biological processes at the molecular level.  Cross listed with MICR 2021.  Prerequisites:  A grade of C or better in LIFE 1010 and CHEM 1000 or 1020.

2240. Medical Microbiology. 5. Designed primarily for nursing and pre-pharmacy majors. Introduces microbiology, including the diversity of prokaryotic and eukaryotic microbes, their structural and physiological properties, and their applied medical significance. Covers the basic principles of the immune system and emphasizes the communicable diseases of man caused by microbial pathogens. Cross listed with MICR/PATB 2240. Prerequisites: LIFE 1010.

3000. Introduction to Molecular Biology. 3. An introduction to molecular biological processes governing cellular events  is presented in the context of the structure of genomes, genes and chromosomes, DNA replication, gene expression, signal transduction pathways and the regulation of cellular processes in disease and development. Experimental methods and technologies will also be discussed. Normally offered fall semester. Prerequisites: LIFE 1010 and CHEM 1030; MOLB/MICR 2021 recommended.

3610. Principles of Biochemistry. 4. One-semester biochemistry course for life-, health- and physical-science students. Introduces a full range of biochemical concepts including discussion of major macromolecules, metabolism, and molecular biology. Prerequisite: LIFE 1010 and a grade of C or better in CHEM 2300 or 2440. (Normally offered fall and summer semesters)

4010. Laboratory Research in Molecular Biology. 1-3 (Max. 12). Undergraduate student will conduct a laboratory or computational research project under the guidance of a Molecular Biology Department faculty member, who will serve as the student's research adviser. Prerequisites: LIFE 1010 or concurrent enrollment, and consent of instructor.

4050. Student ­Seminar. 1 (Max. 4). Exposes students to current topics in molecular biosciences and examines primary journal literature with oral presentations and class discussions. Offered Satisfactory/Unsatisfactory only.  Dual listed with MOLB 5050. Prerequisite: MOLB 3000 and 3610 or 4600. (Normally offered fall and spring semesters.))

4051 [4050]. Departmental Seminar. 1 (Max. 15). Required attendance at a series of weekly seminars presented by visiting faculty on a diverse set of research topics. Undergraduates are able to use one credit hour to partially fulfill the seminar requirement. S/U only. Dual listed with MOLB 5051.

4052. [4050]. Summer Seminar. 1 (Max. 5). Consists of one week of lectures, presented by a renowned scientist from either academics or industry. The material presented is taken from the research program of the speaker. S/U Only.  Dual listed with MOLB 5052.

4100 [3980]. Clinical Biochemistry. 3. An integrated discussion of biochemical, molecular, and physiological principles underlying human medical disorders and the biochemical and molecular genetic tests used in prevention, diagnosis and treatment. Prerequisite: MOLB 3610 or 4600. (Normally offered spring semester)

4170. DNA Cloning Laboratory. 1. Introduces molecular genetic engineering strategies and methodologies in a 5-week laboratory. Dual listed with MOLB 5170. Prerequisite: MOLB 3000 or 3610 or 4600. (Normally offered spring semester)

4180. Protein Isolation and Characterization Laboratory. 1. Strategies and methodologies used in protein isolation and characterization are presented and coordinated with a 5-week laboratory. Dual listed with MOLB 5180. Prerequisite: MOLB 3000 or 3610 or 4600. (Normally offered spring semester)

4250. Bacterial Genetics Laboratory. 1. Introduces genetic manipulations of bacteria using molecular genetic techniques. Dual listed with MOLB 5250; cross listed with MICR 4250. Prerequisites: MOLB 2021, MOLB 3000, and LIFE 3050. (Normally offered spring semester)

4260. Quantitative Microscopy. 1. Acquaints students with principles of light microscopy, use of fluorescent probes and image processing software. Students use phase contrast, fluorescent, and confocal microscopes learning to measure and compare size and intensity of images. Dual listed with MOLB 5260. Prerequisites: MOLB 4600 or LIFE 3600, and PHYS 1120.

4300. Writing in Molecular Biology. 1. [W3<>WC] Writing based on experiments done in the molecular biology lab pods. Assignments include proposals, journal articles, non-technical articles, reports and press releases. Required concurrent enrollment in three spring molecular biology lab pods: MOLB 4170, 4180 and 4250. Prerequisites: completed or concurrent enrollment in MOLB 3610 or 4600.

4310. Foundations of Scholarship and Discovery. 1 (Max. 3). An interdisciplinary discussion based exploration of the nature and creation of knowledge, principles underpinning creativity, inquiry, skepticism, critical analysis, the insecurity of discovery on the frontiers of knowledge, and ethical decision-making. Examines the path from novice to expert thinker and creativity at discipline boundaries. Cross listed with HLSC 4310. Prerequisites: completion of USP WB requirement and junior standing.

4400. Immunology. 4. Biology of immune system; cellular and molecular mechanisms; host resistance to infectious agents; as well as hypersensitivities, autoimmunity, tumor and tissue rejection. Includes laboratory for immunological techniques. Cross listed with PATB 4400. Dual listed with MOLB 5400. Prerequisite: PATB 2220. (Normally offered fall semester)

4440. Microbial Genetics. 3. Discusses microbial genetic approaches to study cell function and provides a molecular foundation for understanding how genes work to elicit phenotypes. Dual listed with MOLB 5440; Cross-listed with MICR 4440. Prerequisites: MOLB 2021 and 3000 and LIFE 3050. (Normally offered spring semester).

4450. Cell and Developmental Genetics. 3. Integrates the genetic control of cell regulation and animal development in both vertebrate and invertebrate model systems such as Drosophila, C. elegans and the mouse. Includes studies of eukaryotic signal transduction, gene control, and current transgenic technologies. Dual listed with MOLB 5450. Prerequisites: MOLB 3000 and 4610, or consent of instructor.

4460. Microbial Physiology and Metabolism. 3. Studies life processes of microbes as mediated by their structures acting in consort, in response to changing environments. Dual listed with MOLB 5460. Cross-listed with MICR 4460. Prerequisites: MOLB 2021 or MOLB 2240 or MICR 2021 or MICR 2240, and MOLB 3610 or MOLB 4610. (Normally offered fall semester)

4485. Computers in Biology. 1. Prepares students to use existing internet resources as research tools in biology without the need to write or install software. Topics include literature searching, multiple sequence alignment and phylogenetic tree construction, primer design, protein homology modeling, and the use of model organism databases. Dual listed with MOLB 5485. Prerequisites: MOLB 3000, 3610 or 4610, or LIFE 3600.

4495. Bioinformatics. 3. Course topics range from classic algorithms in bioinformatics like multiple sequence alignment and phylogenetic tree construction to problems of functional analysis, including computational genomics, gene expression, protein structure, and systems biology analyses. Dual listed with MOLB 5495. Prerequisite:  MOLB 3000 or 3610 or 4610 (MOLB 3610 or 4610 may be taken concurrently with MOLB 4495).

4510. Introductory Virology. 3. Prokaryotic and eukaryotic viruses as infectious agents and models for modern molecular biology. Examines concepts and principles of pathogenesis, host response and the regulation of virus-host interactions. Genome organization, structure and replication will be examined within the context of the co-evolution of virus and host. Dual listed with MOLB 5510. Cross listed with MICR 4510. Prerequisites: MOLB 3610 or 4600 plus 4610.

4520. Public Health Issues in Developing Countries. 2. [(none)<>G] Fundamental principles and practices of public health systems in developing countries will be presented including epidemiology, etiology, integrated management, will be presented within the context of globalization, climate change, and socio-economic, political and cultural constraints. Principles will be illustrated by case studies of major health issues in an interdisciplinary, holistic manner. Cross listed with HLSC 4520. Prerequisite: LIFE 1010, upper division or graduate standing and consent of instructor.

4530. Global Experience in Public Health. 2. A three week inter-semester service learning experience in a developing country. Students will participate, in collaboration with in-country healthcare professionals, in a defined public health education and research program designed to address major public health challenges. Students will gain a global perspective within the cultural context of the developing nation. Cross listed with HLSC 4530. Prerequisites: HLSC/MOLB 4520 and consent of instructor.

4540. Microbial Diversity and Ecology. 4. Introduces the diversity and ecology of soil microbes through an integrated lecture and laboratory course. Emphasis on molecular approaches to analyzing microbial diversity and evolution, and student-directed experimental design. Provides a continuum of realistic research experiences in molecular microbial ecology, from field work to evolutionary analysis of DNA sequence data. Cross listed with ECOL/MICR 4540; Dual listed with MOLB 5540. Prerequisite: MOLB 2021.

4600. Biochemistry 1: Biomolecules. 3. Discussion of the structure and function of major biomolecules, including proteins, carbohydrates, nucleic acids and lipids, will provide the foundation for understanding biochemical, molecular and cellular processes.  Dual listed with MOLB 5600. Prerequisites: Grade of C or better in both MOLB 3000 and CHEM 2420 or 2300. (Normally offered spring semester)

4610. Biochemistry 2: Bioenergetics & Metabolism. 3. Energy transduction and the central biochemical processes are discussed with an emphasis on regulatory controls and integration in metabolism. Dual listed with MOLB 5610. Prerequisite: Grade of C or better in MOLB 4600 or consent of instructor. (Normally offered fall semester)

4615. Biochemistry 3: Molecular Mechanisms. 3. Biochemical and molecular mechanisms underlying cell function, including gene expression and epigenetic regulation, RNA and protein modification and function, assembly of macromolecular complexes, signaling and regulation of the cell cycle, are discussed. Dual listed with MOLB 5620. Prerequisites: Grade of C or better in MOLB 4610 or consent of instructor. (Normally offered spring semester)

4660. Flow and Maintenance of Molecular Genetic Information. 3. Introduction to current research in the flow and maintenance of genetic information, including discussions of  transcription, translation and DNA replication, recombination and repair. New advances in understanding DNA and protein structure and function, genome organization, and gene expression are explored as well as principles of contemporary experimental methods. Dual listed with MOLB 5660. Prerequisites: MOLB 3000 and 3610 or 4610.

4670. Advanced Molecular Cell Biology. 3. Key concepts in eukaryotic cell biology will be presented with a focus on cellular processes that form the basis for human diseases. Cellular organization, dynamics, and signaling will be emphasized. Students will also explore principles of research design by critical reading and discussion of scientific literature. Dual listed with MOLB 5670. Prerequisites: MOLB 3000 or 3610 or 4610.

4850. Undergraduate Teaching Internship. 1 (Max. 4). Undergraduate student will assist in classroom or laboratory teaching under the guidance of an instructor in Molecular Biology. Offered Satisfactory/Unsatisfactory only. Prerequisites: junior standing and consent of instructor.

4990 Topics In:___ 1-3 (Max. 6). Lectures, literature reviews and discussion of selected current topics in different areas of molecular biology. Please check class schedule for current offerings each semester. Prerequisites: MOLB 3000 or 3610 or 4600.

5010. Advanced Laboratory Research in Molecular Biology. 1-3 (Max. 18). Students in PhD, MS and MA programs in Molecular Biology and doctoral students in the Molecular and Cellular Life Sciences (MCLS) graduate program, work in laboratory or computational research projects under the guidance of a Molecular Biology faculty member. Prerequisites: graduate standing and consent of instructor.

5050. Advanced Student Seminar. 2 (Max. 8). Introduction of reading, analyzing, and discussing primary sources in scientific literature. Read primary research papers, give presentations with full participation in critical discussions of data and interpretations of all journal articles analyzed. Papers chosen for review are typically related to research of Molecular Biology Departmental Seminar Series speakers. Offered Satisfactory/Unsatisfactory only. Prerequisites: MOLB 3000 and 3610 or 4600. (Normally offered fall and spring semesters)

5051. Department Seminar. 1 (Max. 15). Required attendance at a series of weekly seminars presented by visiting faculty on a diverse set of research topics. Undergraduates are able to use one credit hour to partially fulfill the seminar requirement. S/U only. Dual listed with MOLB 4051.

5052. Summer Seminar. 1 (Max. 5). Consists of one week of lectures, presented by a renowned scientist from either academics or industry. The material presented is taken from the research program of the speaker. S/U Only. Dual listed with MOLB 4052.

5170. DNA Cloning Laboratory. 1. Introduces molecular genetic engineering strategies and methodologies in a 5-week laboratory. Dual listed with MOLB 4170. Prerequisite: MOLB 3000 or 3610 or 4600. (Normally offered spring semester)

5180. Protein Isolation and Characterization Laboratory. 1. Strategies and methodologies used in protein isolation and characterization are presented and coordinated with a 5-week laboratory. Dual listed with MOLB 4180. Prerequisite: MOLB 3000 or 3610 or 4600. (Normally offered spring semester)

5250. Bacterial Genetics Laboratory. 1. Introduces genetic manipulations of bacteria using molecular genetic techniques. Dual listed with MOLB 4250.  Prerequisites: MOLB 2021, MOLB 3000, and LIFE 3050. (Normally offered spring semester)

5260. Quantitative Microscopy. 1. Acquaints students with principles of light microscopy, use of fluorescent probes and image processing software. Students use phase contrast, fluorescent, and confocal microscopes learning to measure and compare size and intensity of images. Dual listed with MOLB 4260. Prerequisite: MOLB 4600 or LIFE 4600, and PHYS 1120.

5400. Immunology. 4. Biology of the immune system; cellular and molecular mechanisms; host resistance to infectious agents; as well as hypersensitivities, autoimmunity, tumor and tissue rejection. Includes laboratory for immunological techniques. Dual listed with MOLB 4400. Prerequisite: PATB 2220.

5440. Microbial Genetics. 3. Discusses microbial genetic approaches to study cell function and provides a molecular foundation for understanding how genes work to elicit phenotypes. Dual listed with MOLB 4440; Cross-listed with MICR 4440. Prerequisites: MOLB 2021 and 3000 and LIFE 3050. (Normally offered spring semester).

5450. Cell and Developmental Genetics. 3. Integrates the genetic control of cell regulation and animal development in both vertebrate and invertebrate model systems such as Drosophila, C elegans and the mouse. Includes studies of eukaryotic signal transduction, gene control, and current transgenic technologies. Dual listed with MOLB 4450. Prerequisite: MOLB 3000 and 4610, or consent of instructor.

5460. Microbial Physiology and Metabolism I. 3. Studies life processes of microbes as mediated by their structures acting in consort, in response to changing environments. Dual listed with MOLB 4460. Prerequisites: MOLB 2021 or MOLB 2240 or MICR 2021 or MICR 2240, and MOLB 3610 or MOLB 4610.

5485. Computers in Biology. 1. Prepares students to use existing internet resources as research tools in biology without the need to write or install software. Topics include literature searching, multiple sequence alignment and phylogenetic tree construction, primer design, protein homology modeling, and the use of model organism databases. Dual listed with MOLB 4485. Prerequisites: MOLB 3000, 3610 or 4610, or LIFE 3600.

5495. Bioinformatics. 3. Topics range from classic algorithms in bioinformatics like multiple sequence alignment and phylogenetic tree construction to problems of functional analysis, including computational genomics, gene expression, protein structure, and systems biology analyses. Dual listed with MOLB 4495. Prerequisite: graduate standing.

5510. Introduction to Virology. 3. Prokaryotic and eukaryotic viruses as infectious agents and models for modern molecular biology. Examines concepts and principles of pathogenesis, host response and the regulation of virus-host interactions. Genome organization, structure and replication will be examined within the context of the co-evolution of virus and host. Dual listed with MOLB 4510. Prerequisites: MOLB 3610 or 4600 plus 4610.

5520. Molecular and Cellular Life Sciences Laboratory Rotations. 3 (Max. 6). Laboratory research rotations for first year Molecular and Cellular Life Sciences (MCLS) students in the doctoral program. Prerequisite: Enrollment in the Molecular and Cellular Life Sciences (MCLS) program.

5521. Molecular and Cellular Life Sciences Cornerstone. 1. Introduction for students in the Molecular and Cellular Life Sciences program to graduate school and research. Exposes students to diverse faculty research programs and elements fundamental to successful graduate and scientific careers, including scientific publishing, grants, careers, intellectual property, and ethical expectations. Offered Satisfactory/Unsatisfactory only. Prerequisite: Enrollment in the Molecular and Cellular Life Sciences doctoral program. (Normally offered fall semester)

5540. Microbial Diversity and Ecology. 4. Introduces the diversity and ecology of soil microbes through an integrated lecture and laboratory course. Emphasis on molecular approaches to analyzing microbial diversity and evolution, and student-directed experimental design. Provides a continuum of realistic research experiences in molecular microbial ecology, from field work to evolutionary analysis of DNA sequence data. Cross listed with ECOL 5540; Dual listed with MOLB 4540. Prerequisite: MOLB 2021.

5600. Biochemistry 1: Biomolecules. 3. Discussion of the structure and function of major biomolecules, including proteins, carbohydrates, nucleic acids and lipids, will provide the foundation for understanding biochemical, molecular and cellular processes.  Dual listed with MOLB 4600. Credit cannot be earned in both MOLB 4600 and MOLB 3610. Prerequisites: consent of instructor. (Normally offered spring semester)

5610. Biochemistry 2: Bioenergetics & Metabolism. 3. Energy transduction and the central biochemical processes are discussed with an emphasis on regulatory controls and integration in metabolism. Credit cannot be earned in both MOLB 4610 and MOLB 3610. Dual listed with MOLB 4610. Prerequisite:  consent of instructor. (Normally offered fall semester)

5615. Biochemistry 3: Molecular Mechanisms. 3. Biochemical and molecular mechanisms underlying cell function, including gene expression and epigenetic regulation, RNA and protein modification and function, assembly of macromolecular complexes, signaling and regulation of the cell cycle, are discussed. Dual listed with MOLB 4620. Prerequisites: consent of instructor. (Normally offered spring semester)

5630. Advanced Topics in Molecular Biology. 1-3 (Max. 15). Lectures, literature reviews and discussion of selected current topics in molecular biology. Please check class schedule for current offerings each semester. Prerequisite: MOLB 3000 or 3610 or 4600.

5650. Protein Structure and Function. 3. Designed to provide an in-depth look at proteins and their structure. Topics will include protein purification, structure analysis, folding, modification, interactions with other molecules, enzyme mechanism, and other current topics. Prerequisite: MOLB 4610.

5660. Flow of Maintenance of Molecular Genetic Information. 3. Introduction to current research in the flow and maintenance of genetic information, including discussions of  transcription, translation and DNA replication, recombination and repair. New advances in understanding DNA and protein structure and function, genome organization, and gene expression are explored as well as principles of contemporary experimental methods. Dual listed with MOLB 5660. Prerequisites: MOLB 3000 and 3610 or 4610.

5670. Advanced Molecular Cell Biology. 3. Key concepts in eukaryotic cell biology will be presented with a focus on cellular processes that form the basis for human diseases. Cellular organization, dynamics, and signaling will be emphasized. Students will also explore principles of research design by critical reading and discussion of scientific literature. Dual listed with MOLB 4670. Prerequisites: MOLB 3000 or 3610 or 4610.

5900. Practicum in College Teaching. 1-3 (Max. 3). Work in classroom with a major professor. Expected to give some lectures and gain classroom experience. Prerequisite: graduate standing.

5920. Continuing Registration: On Campus. 1-2 (Max. 16). Prerequisite: advanced degree candidacy.

5940. Continuing Registration: Off Campus. 1-2 (Max. 16). Prerequisite: advanced degree candidacy.

5959. Enrichment Studies. 1-3 (Max. 99). Designed to provide an enrichment experience in a variety of topics. Note: credit in this course may not be included in a graduate program of study for degree purposes.

5960. Thesis Research. 1 - 12. (Max 24). Designed for students who are involved in research for their thesis project. Also used for students whose coursework is complete and are writing their thesis. Prerequisite: enrollment in a graduate degree program.

5980. Dissertation Research. 1-12 (Max. 48). Designed for students who are involved in research for their dissertation project. Also used for students whose coursework is complete and are writing their dissertation. Prerequisite: enrollment in a graduate degree program.

5990. Internship. 1 - 12 (Max. 24). Prerequisite: graduate standing.

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