Some of the content on this website requires JavaScript to be enabled in your web browser to function as intended. While the website is still usable without JavaScript, it should be enabled to enjoy the full interactive experience.

Skip to Main Navigation. Each navigation link will open a list of sub navigation links.

Skip to Main Content

UW Technologies Available for Licensing|Wyoming Research Products Center

Engineering Intracellular Sialylation Pathways


Description of Technology:

Engineering Intracellular Sialylation Pathways is a method for producing glycoproteins having sialylated oligosaccharides.  The compositions of the invention comprise enzymes involved in carbohydrate processing and production of nucleotide sugars, nucleotide sequences encoding such enzymes, and cells transformed with these nucleotide sequences. The compositions of the invention are useful in methods for producing complex sialylated glycoproteins in cells of interest including mammalian and insect cells. Also provided are cells of interest that have been recombinantly engineered to produce new forms of sialylated glycoproteins, higher concentrations of sialylated glycoproteins, and/or elevated concentrations of donor substrates required for sialylation, as well as kits for expression of sialylated glycoproteins.


This technology can be used in the biotechnology industry by creating a greater variety of recombinant glycol-products through carbohydrate engineering efforts.

Features and Benefits:

Among the benefits of this technology are potentially lower biotechnology costs, increased variety of glycosylated products to be generated in heterologous hosts, enhanced value of heterologous expression systems and increased application of heterologous cell expression products such as vaccines, therapeutics and diagnostic tools.

For More Information Please Contact:

Davona Douglass, J.D.
(307) 766-2509

Share This Page:

Tech ID



Betenbaugh, Michael Lawrence, Shawn Lee,Yuan Coleman, Timothy

Patent Status

Footer Navigation

University of Wyoming Medallion
1000 E. University Ave. Laramie, WY 82071 // UW Operators (307) 766-1121 // Contact Us // Download Adobe Reader // Accessibility Accessibility information icon