Skip to Main Navigation. Each navigation link will open a list of sub navigation links.

Skip to Main Content

Apply to the University of Wyoming

Global Resource Navigation

Give to UW
Download UW Viewbook
Visit Campus

UW Technologies Available for Licensing

Wyoming Research Products Center

Engineering Intracellular Sialylation Pathways


Description of Technology:

Engineering Intracellular Sialylation Pathways is a method for producing glycoproteins having sialylated oligosaccharides.  The compositions of the invention comprise enzymes involved in carbohydrate processing and production of nucleotide sugars, nucleotide sequences encoding such enzymes, and cells transformed with these nucleotide sequences. The compositions of the invention are useful in methods for producing complex sialylated glycoproteins in cells of interest including mammalian and insect cells. Also provided are cells of interest that have been recombinantly engineered to produce new forms of sialylated glycoproteins, higher concentrations of sialylated glycoproteins, and/or elevated concentrations of donor substrates required for sialylation, as well as kits for expression of sialylated glycoproteins.


This technology can be used in the biotechnology industry by creating a greater variety of recombinant glycol-products through carbohydrate engineering efforts.

Features and Benefits:

Among the benefits of this technology are potentially lower biotechnology costs, increased variety of glycosylated products to be generated in heterologous hosts, enhanced value of heterologous expression systems and increased application of heterologous cell expression products such as vaccines, therapeutics and diagnostic tools.

For More Information Please Contact:

Davona Douglass, J.D.
(307) 766-2509

Tech ID



Betenbaugh, Michael Lawrence, Shawn Lee,Yuan Coleman, Timothy

Patent Status

Share This Page:

1000 E. University Ave. Laramie, WY 82071
UW Operators (307) 766-1121 | Contact Us | Download Adobe Reader

Twitter Icon Youtube Icon Instagram Icon Vimeo Icon Facebook Icon

Accreditation | Emergency Preparedness | Employment at UW | Gainfull Employment | Privacy Policy | Accessibility Accessibility information icon