This technology relates to charge reversible polymers, peptides and their resulting colloidal particles. Their primary and secondary amines are protected as easily hydrolysable amides. The amides are relatively stable at neutral pH but quickly hydrolyze at low pH. These polymers, peptides or particles are thus charge-reversible: at neutral pH they are negatively charged but become positively charged at acidic pH.
Charge Reversible Polymers can be developed for use as drug delivery carriers to solid tumors and lysosomes. Charge Reversible Polymers can also be used as gene delivery carriers, as well.
This technology, as a drug delivery carrier, will be able to localize and directly release drugs into the nucleus of a cell and would circumvent the multi-drug resistance and intracellular drug-resistance to effectively deliver drugs to the vicinity of DNA, leading to high therapeutic efficacy.
Davona Douglass, J.D.Director(307) firstname.lastname@example.org
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