Skip to Main Navigation. Each navigation link will open a list of sub navigation links.

Skip to Main Content

Apply to the University of Wyoming apply now

Global Resource Navigation

Visit Campus
Download UW Viewbook
Give to UW

TRPV1 Knock-In Method and TRPV1 Mice for Adipose Tissue Modulation

UW ID: 16-102

 

Description of Technology

According to the Center for Disease Control, more than one third of American adults are considered obese. Obesity foreshadows metabolic dysfunctions and leads to type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases. An imbalance between energy intake and expenditure caused by sedentary life style, lack of physical exercise and preference for fat-rich food leads to obesity. As a result, obesity impacts the physiological and psychological well-being of society as a whole from an individual and public health perspective. Therefore, it is important to develop strategies to counteract obesity and metabolic diseases.

Researchers at the University of Wyoming have created a research plan to determine the effect of dietary CAP, to evaluate the effect of dietary CAP after adding in TRPV1, and to deduce the mechanism by which a high fat diet suppresses TRPV1 expression in adipose tissue. They have also created animal (mice) models available for conducting research in this area.

 

Applications

  • These innovative approaches will explain the role of non-neuronal, adipose tissue specific expression and activity of TRPV1.
  • The work will also add new knowledge on the regulation of TRPV1 expression by adipose tissue derived BDNF.
 

Features & Benefits

  • This research will significantly advance our current knowledge on the role of TRPV1 specifically expressed and localized in adipose tissues in the regulation of metabolism and energy expenditure.
  • The activation of TRPV1 protein is believed to be beneficial in countering diet-induced obesity.
  • This research will contribute to long-term goals for developing new pharmacotherapy to counter obesity.

Downloadable PDF: 16-102

Inventors:

Thyagarajan, Baskaran
Baskaran, Padma

 

Patent Status:

Patent Pending

Contact Us:

University of Wyoming Technology Transfer and Research Products Center

1000 E. University Ave.

Laramie, WY

82071

Phone: 307-766-2520

Fax: 307-766-2530

Email: WyomingInvents@uwyo.edu


Share This Page:

Contact Us

Wyoming Technology Transfer and Research Products Center

Dept. 3672

1000 E. University Ave.

Laramie, WY 82071

Phone: (307) 766-2520

Fax: (307) 766-2530

Email: WyomingInvents@uwyo.edu

Find us on Facebook (Link opens a new window) Find us on YouTube (Link opens a new window)

1000 E. University Ave. Laramie, WY 82071
UW Operators (307) 766-1121 | Contact Us | Download Adobe Reader

Twitter Icon Youtube Icon Instagram Icon Facebook Icon

Accreditation | Emergency Preparedness | Employment at UW | Gainful Employment | Privacy Policy | Accessibility Accessibility information icon