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TRPV1 Knock-In Method and TRPV1 Mice for Adipose Tissue Modulation

UW ID: 16-102


Description of Technology

          According to the Center for Disease Control, more than one third of American adults are considered obese. Obesity foreshadows metabolic dysfunctions and leads to type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases. An imbalance between energy intake and expenditure caused by sedentary life style, lack of physical exercise and preference for fat-rich food leads to obesity. As a result, obesity impacts the physiological and psychological well-being of society as a whole from an individual and public health perspective. Therefore, it is important to develop strategies to counteract obesity and metabolic diseases.

          Researchers at the University of Wyoming have created a research plan to determine the effect of dietary CAP, to evaluate the effect of dietary CAP after adding in TRPV1, and to deduce the mechanism by which a high fat diet suppresses TRPV1 expression in adipose tissue. They have also created animal (mice) models available for conducting research in this area.



  • These innovative approaches will explain the role of non-neuronal, adipose tissue specific expression and activity of TRPV1.

  • The work will also add new knowledge on the regulation of TRPV1 expression by adipose tissue derived BDNF.


Features & Benefits

  • This research will significantly advance our current knowledge on the role of TRPV1 specifically expressed and localized in adipose tissues in the regulation of metabolism and energy expenditure.

  • The activation of TRPV1 protein is believed to be beneficial in countering diet-induced obesity.

  • This research will contribute to long-term goals for developing new pharmacotherapy to counter obesity.

Downloadable PDF: 16-102


Thyagarajan, Baskaran
Baskaran, Padma


Patent Status:

Patent Pending

Contact Us:

University of Wyoming Technology Transfer and Research Products Center

Dept. 3672

1000 E. University Ave.

Laramie, WY


Phone: 307-766-2520

Fax: 307-766-2530


Contact Us

Wyoming Technology Transfer and Research Products Center

Dept. 3672

1000 E. University Ave.

Laramie, WY 82071

Phone: (307) 766-2520

Fax: (307) 766-2530


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