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Near-Infrared Window Light-Mediated Control of Implanted Cells for Immunosuppression and Regenerative Medicine

UW ID: 18-002


Description of Technology

          Cellular therapy is a medical procedure that implants cells into a patient to treat a disease or stimulate the regeneration of tissue. Many different cell types have been tested and are pending clinical use for a variety of applications. The drawback to these cells is that once they are implanted into the patient, the behavior of the cells cannot be controlled and they spread throughout the body. This makes it difficult to achieve the same results in separate patients. Another issue with these cells is that the immune system must be suppressed so the body accepts the new cells. Since there is no way to control where the cells move, systematic immunosuppression, or suppressing the immune system of the entire body, must take place to ensure the patient’s body will not reject the new cells. Systematic immunosuppression brings many problems with it including an increased risk of patients becoming sick while undergoing treatment.

          In order to correct many of these problems, researchers at the University of Wyoming have created cells that react to near-infrared therapeutic window (NIRW) light. The NIRW light is a low energy light that penetrates deep into tissues without causing irritation to the patient. Once these cells are implanted into the patient, they can be controlled by an external light source to target specific locations. This amount of control allows repeatability of results from patient to patient. It also eliminates the need for systematic immunosuppression. Instead, only the immune system of the specific region where the cells are implanted needs to be suppressed. These cells could save a lot of patients from complications during cellular therapy.

 

Applications

          The NIRW reactive cells can be used in cellular therapy where extra cells need to be implanted into a patient in order to aid healing. Their ability to better repeat results in patients gives doctors a better understanding of how to treat specific patients.

 

Features & Benefits

  • Reacts to NIRW light
  • Better target specific locations
  • Increases repeatability of results
  • Eliminates to need for systematic immunosuppression

Downloadable PDF: 18-002

Inventors: 

Jared Bushman


Patent Status:  

Patent Pending


Contact Us: 

University of Wyoming Technology Transfer and Research Products Center 

Dept. 3672

1000 E. University Ave. 

Laramie, WY 

82071 

Phone: 307-766-2520

Fax: 307-766-2530

Email: WyomingInvents@uwyo.edu


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Wyoming Technology Transfer and Research Products Center

Dept. 3672

1000 E. University Ave.

Laramie, WY 82071

Phone: (307) 766-2520

Fax: (307) 766-2530

Email: WyomingInvents@uwyo.edu

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