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Modifying Insect Cell Glycosylation Pathways with Baculovirus Expression Vectors

UW ID: 99-001


Description of Technology
 

The invention first provides a baculovirus expression vector characterized as either: (a) comprising at least a first and a second glycosylation enzyme transcription unit, the transcriptional units comprising a first and a second structural gene encoding a first and second oligosaccharide processing enzyme, each gene operatively positioned under the control of and in frame with a promoter; or (b) compromising at least a first glycosylation enzyme transcriptional unit, the transcriptional unit comprising a structural gene encoding an oligosaccharide processing enzyme, the gene operatively positioned under the control of a baculoviral immediate early, delayed early, early or late promoter.


Applications

The insect cells can be used for high volume, glycosylated protein production.


Features & Benefits

This cell line has normal morphologies, growth properties and remains competent as a host for baculovirus expression vectors. The cell line offers a distinct advantage over unmodified hosts for the baculovirus-meditated production of more authentic recombinant N-glycoproteins.

Inventors: 

Jarvis, Donald


Patent Status: 
 

Patent Issued


Contact Us: 

University of Wyoming Technology Transfer and Research Products Center 

Dept. 3672

1000 E. University Ave. 

Laramie, WY 

82071 

Phone: 307-766-2520

Fax: 307-766-2530


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Contact Us

Wyoming Technology Transfer and Research Products Center

Dept. 3672

1000 E. University Ave.

Laramie, WY 82071

Phone: (307) 766-2520

Fax: (307) 766-2530

Email: WyomingInvents@uwyo.edu

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