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Department of Veterinary Sciences|College of Agriculture and Natural Resources

PATB 4130/5130 - Mammalian Pathobiology

Syllabus

COURSE SYLLABUS

PATB 4130/5130

 

 

 

 

Mammalian Pathobiology

 

 

 

 

 

Monday, Wednesday, Friday 4:10 - 5:00 PM

 

The class was offered for first in fall 2009

 

Dr. Rudolph Virchow, the founder of comparative pathology  Virchow was the son of a butcher.  Among other achievements, he discovered the cause of trichinosis.

The Blocker History of Medicine
Collections, University Texas Medical Branch, Galveston

 

Instructors: Dr. Donal O'Toole; Dr. Don Montgomery; Dr. Shannon Swist
Phone: 307 742 6638
E-mail(s): DOT@uwyo.edu  Office: #119, WSVL
Office Hours: Monday and Friday 8:00 - 10:00

Prerequisites:  

  • C grade or better in BIOL 2022 

  • Students with background in Immunology (PATB or MOLB 4400) will be at an advantage in this class


Course Description:

This course acquaints students with anatomical basis of disease in mammals.  Its emphasis is on concepts of disease pathogenesis, and the gross, microscopic, and clinicopathological changes associated with disease: cell injury and death; cellular degeneration; disturbances of growth and circulation; neoplasia; inflammation; and recognition of gross and microscopic tissue changes.


Disability Statement:

If you have a physical, learning, or psychological disability and require accommodations, please let the instructor know as soon as possible. You must register with, and provide documentation of your disability to University Disability Support Services (UDSS) in SEO, room 330 Knight Hall.


Objective:

For most students, this course will represent their first formal introduction to the basis for disease. Students will be expected to develop a thorough understanding of the cellular basis of disease, based on four examinations given during the course, with each examination worth 100 points, for a total of 400 points.  Graduate students taking this course at the 5000 level should anticipate a 20% greater effort.


Readings:

This is the main text used by Dr. Montgomery and Dr. O'Toole.  You do not need to buy it for the course, but if you will have a career in which you anticipate you will need a reference text in pathology for animals, this is it.  It costs about $90 from Amazon.  It is good value, given that it is almost 1500 pages and is illustrated in color.  We will cover only general pathology (chapters 1  - 6).  Organ-specific pathology comprises the bulk of the book (chapters 7 - 20).  Drs. McGavin and Zachary are both former editors of the journal Veterinary Pathology (see below), and it shows.

  • Jubb, Kennedy & Palmer's Pathology of Domestic Animals, 5th edition. Vols. 1-3, eds. M. Grant Maxie, 2007, Saunders.

This three-volume text is organ-based, rather than covers general pathology.  Each chapter begins with a useful review of general reaction patterns in that organ or tissue.  It is the bible of veterinary pathology, so go to this text if you need an authoritative review of a disease topic.  Each volume is about $195.

  • Cell, Tissue and Disease - The Basis of Pathology, 3rd edition.  N Woolf, 2000.   ISBN: 0702024783


Course Requirements/Assignments:

Students will be examined 4 times during the course.  The examined material will be cumulative.  The final exam will be for 25% of the grade for undergraduates.  It will cover all material covered to that date.  Students taking the course at the 5000 level have an essay assignment in a topic pertinent to the course and will present it before the end of the semester.  This involves an extensive literature review, a formal paper written in the format of the journal Veterinary Pathology, posting the information on the class's web site, and oral presentation to the class. Graduate students do this for 20% of the final grade.  The oral presentation will be evaluated based on ability to engage the class, accurate responses to questions, quality of the information, presentation style, quality of slides, and creativity.  The written presentation will be ~10 - 12 pages long, in journal format, with current citations. It will be evaluated for writing style, topicality, overview of the literature, and ability to incorporate concepts in pathology.  Points will be lost for spelling or grammatical errors, and failure to cover the topic comprehensively.  A good strategy is to find a good topic review paper at the outset, and use that as a guide for themes and targets.  The main challenges are a) identifying good and topical papers in the area b) not being overwhelmed and c) making creative synthesis of the information.  This is a pathology class and the term paper should focus on pathology, not clinical medicine, molecular methods, or your personal opinion.


Grading Standards:

Grading is based on total points earned on four examinations.  Exams consist of any combination of definition/description, multiple choice, matching, true/false or short answer questions.  They cover material presented in lectures, including presentations by students taking the class at the 5000 level.

PATB 4130 - undergraduates

Exam #1

100 pts

Exam #2

100 pts

Exam #3

100 pts 

Exam #4

100 pts

 

PATB 5130 - graduate students

Exam #1

100 pts

Exam #2

100 pts

Exam #3

100 pts 

Exam #4

100 pts

Paper/presentation 100 pts

Graduate students will present a term paper and give a short (~20 minute) oral presentation to the class on a topic agreed with the instructor. The topic should be of broad interest for the class.  The presentation should aim to reinforce themes covered during the course (e.g., specific aspects of inflammation, degeneration, neoplasia, etc.).  It should NOT be a topic you presented on previously in another class.  If you cannot identify a topic, the instructor will provide one.  If you cite a paper, you are expected to have read it - not just the abstract.  If there is evidence of plagiarism, or cutting 'n' pasting from review or other papers, the student automatically gets a 0.  The presentation will be posted on the class web site, along with the term paper.  Presentations will be given at the end of the semester (typically end of November/early December).  You will be assigned a time slot, and are expected to be ready to present during the assigned slot.  You can submit drafts of the PPT and/or term paper for critique by the instructors - this will ensure you are on target with the material.

Final grades are based on total points earned in the course as shown below.

Letter Grade

% Grade

A

   90 and above

B

   80 - 89.99999

C

   70 - 79.99999

D

   60 - 69.99999

F

< 60

*Minimum points required may be lowered (but not be raised) at the discretion of the instructor.   For graduate students, the review paper/web posting/oral presentation represents 20% of their grade.


Attendance/Participation Policy:

Class attendance is expected for a complete understanding of course material. Make-up exams will be granted with an official University Authorized Absence Form (i.e. the infamous yellow slip) issued by the Dean of Students Office and at the discretion of the instructor. Unless absence is due to an emergency, students must notify the instructor (or coordinator) before the absence such that appropriate make-up arrangements can be made. Unless otherwise arranged, make-up exams MUST be completed before the 2nd class period following the scheduled exam, so that exams may be handed back in a timely fashion.


Academic Honesty:

The University of Wyoming is built upon a strong foundation of integrity, respect and trust. All members of the university community have a responsibility to be honest and the right to expect honesty from others. Any form of academic dishonesty is unacceptable to our community and will not be tolerated [from the UW General Bulletin]. Teachers and students should report suspected violations of standards of academic honesty to the instructor, department head, or dean.  More fun University regulations can be found here.


Class schedule

 

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