WILLIAM JAMES MURDOCH
Education/Academic Advancement: B.S., Animal Science, Delaware Valley College (1975); M.S., Ph.D., Reproductive Physiology, West Virginia University (1977, 1980); Assistant/Associate/Professor of Reproductive Biology, Department of Animal Science, University of Wyoming (1980/86/91-)
Professional Affiliates: Society for the Study of
Reproduction; American Society of Animal Science; Endocrine Society; American
Association for the Advancement of Science; Society for
Refereed Journal Manuscripts and Review Articles/Book Chapters:
Murdoch WJ, Lewis GS, Inskeep EK, Tillson SA 1978 The effect of a progesterone-releasing intrauterine contraceptive device on uterine secretion of prostaglandin F2 alpha and lifespan of corpora lutea in the ewe. American Journal of Obstetrics & Gynecology 132:81-86.
Inskeep EK, Murdoch WJ 1980 Relation of ovarian functions to uterine and ovarian secretion of prostaglandins during the estrous cycle and early pregnancy in the ewe and cow. International Review of Physiology 22:325-356.
Murdoch WJ, Dailey RA, Inskeep EK 1981 Preovulatory changes in prostaglandins E2 and F2 alpha in ovine follicles. Journal of Animal Science 53:192-205.
Murdoch WJ, Inskeep EK 1981 Factors affecting luteinization of sheep and
rabbit ovarian follicles: follicular contents and luteinizing hormone. Biology
of
Murdoch WJ, Dunn TG 1982 Alterations in follicular steroid hormones during
the preovulatory period in the ewe. Biology of
Murdoch WJ, Nix KJ, Dunn TG 1983 Dynamics of ovarian blood supply to
periovulatory follicles of the ewe. Biology of
Murdoch WJ, Dunn TG 1983 Luteal function after ovulation blockade by
intrafollicular injection of indomethacin in the ewe. Journal of
Murdoch WJ, DeSilva M, Dunn TG 1983 Luteal phase insufficiency in the ewe as a consequence of premature induction of ovulation by intrafollicular injection of gonadotropins. Journal of Animal Science 57:1507-1511.
Murdoch WJ, Myers DA 1983 Effect of treatment of estrous ewes with
indomethacin on the distribution of ovarian blood to the periovulatory
follicle. Biology of
Mathews MV, Murdoch WJ 1984 Increased secretion of luteinizing hormone in prepuberal ewes treated with an antagonist of opiates. Domestic Animal Endocrinology 1:167-173.
Myers DA, Lewis RV, Dunn TG, Murdoch WJ 1984 Failure to detect luteinizing hormone-releasing hormone-like bioactivity in fluid of preovulatory ovine follicles. Domestic Animal Endocrinology 1:291-298.
Swift BL, Murdoch WJ, Dahlgren RR 1984 Anemia associated with anestrus in beef heifers inoculated with Anaplasma marginale: endocrinology and ovarian changes. Theriogenology 22:643-649.
Murdoch WJ 1985 Follicular determinants of ovulation in the ewe. Domestic Animal Endocrinology 2:105-121.
Myers DA, Murdoch WJ, Villemez CL 1985 Protein-peptide conjugation by a two-phase reaction. Biochemical Journal 227:343.
Rhodes RC, Fleming MW, Murdoch WJ, Inskeep EK 1985 Formation of cyclic adenosine monophosphate (cAMP) in the preovulatory rabbit follicle: role of prostaglandins and steroids. Prostaglandins 29:217-231.
Roberts AJ, Dunn TG, Murdoch WJ 1985 Induction of ovulation in proestrous ewes: identification of the ovulatory follicle and functional status of the corpus luteum. Domestic Animal Endocrinology 2:207-210.
Murdoch WJ, Peterson TA, Van Kirk EA, Vincent DL, Inskeep EK 1986 Interactive
roles of progesterone, prostaglandins and collagenase in the ovulatory
mechanism of the ewe. Biology of
Murdoch WJ 1986 Accumulation of thromboxane B4 within periovulatory ovine follicles: relationship to adhesion of platelets to endothelium. Prostaglandins 32:597-604.
Murdoch WJ, Cavender JL 1987 Mechanisms of ovulation. Advances in Contraceptive Delivery Systems 3:353-366.
Rahmanian MS, Murdoch WJ 1987 Function of ovine corpora lutea after administration of luteinizing hormone-releasing hormone. Journal of Animal Science 64:648-655.
Murdoch WJ 1987 Treatment of sheep with prostaglandin F2 alpha enhances production of a luteal chemoattractant for eosinophils. American Journal of Reproductive Immunology & Microbiology 15:52-56.
Murdoch WJ, Steadman LE, Belden EL 1988 Immunoregulation of luteolysis. Medical Hypotheses 29:197-199.
Murdoch WJ, Farris ML 1988 Prostaglandin E2-9-ketoreductase activity of preovulatory ovine follicles. Journal of Animal Science 66:2924-2929.
Cavender JL, Murdoch WJ 1988 Morphological studies of the microcirculatory
system of periovulatory ovine follicles. Biology of
Steadman LE, Murdoch WJ 1988 Production of leukotriene B4 by luteal tissues of sheep treated with prostaglandin F2 alpha. Prostaglandins 36:741-745.
Murdoch WJ 1988 Disruption of cellular associations within the granulosal compartment of periovulatory ovine follicles: relationship to maturation of the oocyte and regulation by prostaglandins. Cell & Tissue Research 252:459-462.
Murdoch WJ 1989 Effect of a steroidal (prednisolone) and nonsteroidal (indomethacin) antiinflammatory agent on ovulation and follicular accumulation of prostaglandin F2 alpha in sheep. Prostaglandins 37:331-334.
Jensen R, Pier AC, Kaltenbach CC, Murdoch WJ, Becerra VM, Mills KW, Robinson JL 1989 Evaluation of histopathologic and physiologic changes in cows having premature births after consuming Ponderosa pine needles. American Journal of Veterinary Research 50:285-289.
Van Kirk EA,
Murdoch WJ, Cavender JL 1989 Effect of indomethacin on the vascular architecture of preovulatory ovine follicles: possible implication in the luteinized unruptured follicle syndrome. Fertility & Sterility 51:153-155.
Murdoch WJ, McCormick RJ 1989 Production of low molecular weight
chemoattractants for leukocytes by periovulatory ovine follicles. Biology
of
Carvalho CB, Yeik BS, Murdoch WJ 1989 Significance of follicular cyclooxygenase and lipoxygenase pathways of metabolism of arachidonate in sheep. Prostaglandins 37:553-558.
Steadman LE,
Field RA, Ho L, Russell WC, Riley ML, Murdoch WJ, Van Kirk
EA,
Murdoch WJ 1990 Localization and hormonal regulation of ovarian production of histamine in the sheep. Life Sciences 46:1961-1965.
Johnson GA, Wilken C, Van Kirk EA, Belden EL, Murdoch WJ 1990 Toward regulation of gonadal function by a synthetic hybrid molecule composed of gonadotropin and Fc fragment of immunoglobulin G. American Journal of Reproductive Immunology 23:22-25.
Eggleston DL, Wilken C, Van Kirk EA, Slaughter RG, Ji TH, Murdoch WJ 1990 Progesterone induces expression of endometrial messenger RNA encoding for cyclooxygenase. Prostaglandins 39:675-683.
Alexander BM, Van Kirk EA, Murdoch WJ 1990 Secretion of platelet-activating factor by periovulatory ovine follicles. Life Sciences 47:865-868.
Field RA, Maiorano G, Hinds FC, Murdoch WJ, Riley ML 1990 Bone ossification and carcass characteristics of wethers given silastic implants containing estradiol. Journal of Animal Science 68:3663-3668.
Wilken C, Van Kirk EA, Slaughter RG, Ji TH, Murdoch WJ 1990 Increased production of ovarian thromboxane in gonadotropin-treated immature rats: relationship to the ovulatory process. Prostaglandins 40:637-646.
Murdoch WJ, Steadman LE 1991 Investigations concerning the relationship of ovarian eosinophilia to ovulation and luteal function in the sheep. American Journal of Reproductive Immunology 25:81-87.
Sankot AP, Murdoch WJ 1991 Luteotropic influence of the ovine uterus. Domestic Animal Endocrinology 8:369-375.
Ji I, Slaughter RG, Ellis JE, Ji TH, Murdoch WJ 1991 Analyses of ovine corpora lutea for tumor necrosis factor mRNA and bioactivity during prostaglandin-induced luteolysis. Molecular & Cellular Endocrinology 81:77-80.
Murdoch WJ, McCormick RJ 1991 Leukocyte chemoattraction and periovulatory
follicular processes. In: Signaling Mechanisms and Gene Expression in the
Ovary (Serono Symposia,
Murdoch WJ, Slaughter RG, Ji TH 1991 In situ hybridization analysis of ovarian prostaglandin endoperoxide synthase mRNA throughout the periovulatory period of the ewe. Domestic Animal Endocrinology 8:457-459.
Murdoch WJ, McCormick RJ 1991 Dose-dependent effects of indomethacin on
ovulation in the sheep: relationship to follicular prostaglandin production,
steroidogenesis, collagenolysis and leukocyte chemotaxis. Biology of
Murdoch WJ, McCormick RJ 1992 Sequence analysis of leukocyte chemoattractant peptides secreted by periovulatory ovine follicles. Biochemical & Biophysical Research Communications 184:848-852.
Beaver CJ, Murdoch WJ 1992 Ovarian and uterine prostaglandin E2-9-ketoreductase activity in cyclic and pregnant ewes. Prostaglandins 44:37-42.
Murdoch WJ 1992 Comparative morphometry and steroidogenic function of antral ovine follicles destined for ovulation or atresia. Domestic Animal Endocrinology 9:47-52.
Murdoch WJ, McCormick RJ 1992 Enhanced degradation of collagen within apical vs. basal wall of ovulatory ovine follicle. American Journal of Physiology 263:E221-E225.
Murdoch WJ, McCormick RJ 1993 Mechanisms and physiological implications of
leucocyte chemoattraction into periovulatory ovine follicles. Journal of
Alexander BM, Van Kirk EA, Rose JD, Murdoch WJ, Moss GE 1993 Effects of season and estradiol on concentrations of histamine within discrete brain regions of ovariectomized ewes. Domestic Animal Endocrinology 10:7-14.
Ackerman RC, Murdoch WJ 1993 Prostaglandin-induced apoptosis of ovarian surface epithelial cells. Prostaglandins 45:473-483.
Yoo J, Zeng H, Ji I, Murdoch WJ, Ji TH 1993 Carboxy-terminal amino acids of the subunit play common and different roles in human choriogonadotropin and follitropin. Journal of Biological Chemistry 268:13034-13042.
Murdoch WJ, Hansen TR, McPherson LA 1993 Role of eicosanoids in vertebrate ovulation. Prostaglandins 46:85-115.
McPherson LA, Van Kirk EA, Murdoch WJ 1993 Localization of stress protein-70 in ovine corpora lutea during prostaglandin-induced luteolysis. Prostaglandins 46:433-440.
Murdoch WJ 1994 Ovarian surface epithelium during ovulatory and anovulatory ovine estrous cycles. Anatomical Record 240:322-326.
Murdoch WJ 1994 Immunoregulation of mammalian fertility. Life Sciences 55:1871-1886.
Asirvatham AL,
Alexander BM, Murdoch WJ, Hallford DM, Moss GE 1994
Seasonal effects of antihistamine on serum luteinizing hormone, growth hormone
and prolactin in ovariectomized ewes. Animal
Ackerman RC,
Murdoch WJ 1994 Animal reproduction: overview of the reproductive system.
In: Encyclopedia of Agricultural Science. C. J. Arntzen (ed.). Academic Press,
Murdoch WJ 1994 Male reproduction. In: Encyclopedia
of Agricultural Science. C. J. Arntzen (ed.). Academic
Press,
Murdoch WJ 1994 Female reproduction. In: Encyclopedia
of Agricultural Science. C. J. Arntzen (ed.). Academic
Press,
Murdoch WJ 1994 Pregnancy. In: Encyclopedia of
Agricultural Science. C. J. Arntzen (ed.). Academic
Press,
Johnson GA, Hansen TR, Austin KJ, Van Kirk EA, Murdoch WJ 1995
Baculovirus-insect cell production of bioactive choriogonadotropin-immunoglobulin
G heavy chain fusion proteins. Biology of
Ji TH, Murdoch WJ, Ji I 1995 Activation of membrane receptors. Endocrine 3:187-194.
Murdoch WJ 1995 A synopsis of fundamental advances in animal reproductive biology. Animal Biology 4:79-99.
Murdoch WJ 1995 Programmed cell death in preovulatory ovine follicles. Biology
of
Murdoch WJ 1995 Temporal relationships between stress protein induction, progesterone withdrawal, and apoptosis in corpora lutea of ewes treated with prostaglandin F2 alpha. Journal of Animal Science 73:1789-1792.
Alexander BM, Murdoch WJ, Van Kirk EA, Moss GE 1995 Attenuation of the
estradiol-induced surge release of luteinizing hormone by antihistamine in
ovariectomized ewes. Animal
Murdoch WJ 1995 Immunolocalization of a gonadotropin-releasing hormone receptor site in murine endometrium that mediates apoptosis. Cell & Tissue Research 282:527-529.
Murdoch WJ 1995 Endothelial cell death in preovulatory ovine follicles:
possible implication in the biomechanics of rupture. Journal of
Murdoch WJ 1996 Differential effects of indomethacin on the sheep ovary: prostaglandin biosynthesis, intracellular calcium, apoptosis, and ovulation. Prostaglandins 52:497-506.
Murdoch WJ, Austin KJ, Hansen TR 1996 Polyubiquitin up-regulation in corpora lutea of prostaglandin-treated ewes. Endocrinology 137:4526-4529.
Murdoch WJ 1996 Microtubular dynamics in granulosa cells of periovulatory
follicles and granulosa-derived (large) lutein cells of sheep: relationships to
the steroidogenic folliculo-luteal shift and functional luteolysis. Biology
of
Murdoch WJ 1996 Ovarian surface epithelium, ovulation, and carcinogenesis. Biological Reviews 71:529-543.
Schuett GW, Harlow HJ, Rose JD, Van Kirk EA, Murdoch WJ 1996 Levels of plasma corticosterone and testosterone in male copperheads (Agkistrodon contortix) following staged fights. Hormones & Behavior 30:60-68.
Murdoch WJ, Van Kirk EA 1997 Oestradiol inhibits spontaneous and cisplatin-induced apoptosis in epithelial ovarian cancer cells: relationship to DNA repair capacity. Apoptosis 2:478-484.
Murdoch WJ,
Schuett GW, Harlow HJ, Rose JD, Van Kirk EA, Murdoch WJ 1997 Annual cycle of plasma testosterone in male copperheads Agkistrodon contortix: relationship to timing of spermatogenesis, mating, and agonistic behavior. General & Comparative Endocrinology 105:417-424.
Murdoch WJ, Van Kirk EA 1998 Luteal dysfunction in ewes induced to ovulate early in the follicular phase. Endocrinology 139:3480-3484.
Murdoch WJ 1998 Regulation of collagenolysis and cell death by plasmin
within the formative stigma of preovulatory ovine follicles. Journal of
Murdoch WJ 1998 Perturbation of sheep ovarian surface epithelial cells by ovulation: evidence for roles of progesterone and poly(ADP-ribose) polymerase in the restoration of DNA integrity. Journal of Endocrinology 156:503-508.
Vierk JE, Hansen TR, Austin KJ, Van Kirk EA, Hess BW, Murdoch WJ 1998 Inhibition by tocopherol of prostaglandin-induced apoptosis in ovine corpora lutea. Prostaglandins & Other Lipid Mediators 56:265-276.
Murdoch WJ 1998 Inhibition by oestradiol of oxidative stress-induced
apoptosis in pig ovarian tissues. Journal of
Murdoch WJ, Van Kirk EA, Murdoch J 1999 Plasmin
cleaves tumor necrosis factor alpha exodomain from sheep follicular
endothelium: implication in the ovulatory process. Biology of
Johnson GA, Austin KJ, Collins AM, Murdoch WJ, Hansen TR 1999 Endometrial ISG17 mRNA and a related mRNA are induced by interferon-tau and localized to glandular epithelial and stromal cells from pregnant cows. Endocrine 10:243-252.
Murdoch WJ 1999 Plasmin-tumour necrosis factor interaction in the ovulatory
process. Journal of
Lund SA, Murdoch J, Van Kirk EA, Murdoch WJ 1999 Mitogenic and antioxidant
mechanisms of estradiol action in preovulatory ovine follicles: relevance to
luteal function. Biology of
Murdoch WJ, Wilken C, Young DA 1999 Sequence of apoptosis and inflammatory
necrosis within the formative ovulatory site of sheep follicles. Journal of
Murdoch J, Van Kirk EA, Murdoch WJ 1999 Hormonal control
of urokinase plasminogen activator secretion by sheep ovarian surface
epithelial cells. Biology of
Johnson ML, Murdoch J, Van Kirk EA, Kaltenbach JE, Murdoch WJ 1999 Tumor
necrosis factor alpha regulates collagenolytic activity in preovulatory ovine
follicles: relationship to cytokine secretion by the oocyte-cumulus cell
complex. Biology of
Murdoch WJ, Lund SA 1999 Prostaglandin-independent anovulatory mechanism of
indomethacin action: inhibition of tumor necrosis factor alpha-induced sheep
ovarian cell apoptosis. Biology of
Murdoch WJ 2000 Proteolytic and cellular death mechanisms in ovulatory ovarian rupture. Biological Signals & Receptors 9:102-114.
Kiyma Z, Adams TE, Hess BW, Riley ML, Murdoch WJ, Moss GE 2000 Gonadal function, sexual behavior, feedlot performance, and carcass traits of ram lambs actively immunized against GnRH. Journal of Animal Science 78:2237-2243.
Gottsch ML, Van Kirk EA, Murdoch WJ 2000 Tumour necrosis factor alpha up-regulates matrix metalloproteinase-2 activity in periovulatory ovine follicles: metamorphic and endocrine implications. Reproduction, Fertility & Development 12:75-80.
Murdoch WJ, Van Kirk EA 2000 Aetiology of attenuated luteal development in prednisolone-induced eosinopenic ewes. Reproduction, Fertility & Development 12:127-132.
Murdoch WJ, Van Kirk EA 2001 Estrogenic up-regulation of DNA polymerase beta
in oocytes of preovulatory ovine follicles. Molecular
McDonnel AC, Murdoch WJ 2001 High-dose progesterone inhibition of urokinase secretion and invasive activity by SKOV-3 ovarian carcinoma cells: evidence for a receptor-independent nongenomic effect on the plasma membrane. Journal of Steroid Biochemistry & Molecular Biology 78:185-191.
Murdoch WJ, Townsend RS, McDonnel AC 2001 Ovulation-induced DNA damage in
ovarian surface epithelial cells of ewes: prospective regulatory mechanisms of
repair/survival and apoptosis. Biology of
Murdoch WJ, Van Kirk EA 2002 Steroid hormonal regulation of proliferative, p53 tumor suppressor, and apoptotic responses of sheep ovarian surface epithelial cells. Molecular & Cellular Endocrinology 186:61-67.
Murdoch WJ, McDonnel AC 2002 Roles of the ovarian surface epithelium in
ovulation and carcinogenesis.
Gottsch ML, Van Kirk EA, Murdoch WJ 2002 Role of matrix
metalloproteinase-2 in the ovulatory folliculo-luteal transition of ewes.
Schuett GW, Carlisle SL, Holycross AT, O’Leile JK, Hardy DL, Van Kirk
EA, Murdoch WJ 2002 Mating system of male mojave
rattlesnakes (Crotalus scutulatus): seasonal timing of mating, agonistic
behavior, spermatogenesis, sexual segment of the kidney, and plasma sex
steroids. In: Biology of the Vipers. G. W. Schuett, M. Höggren, M. E.
Douglas, and H. W. Greene (eds.).
Murdoch WJ, Gottsch ML 2003 Proteolytic mechanisms in the ovulatory folliculo-luteal transformation. Connective Tissue Research 44:50-57.
Murdoch WJ 2003 Metaplastic potential of p53 down-regulation in ovarian surface epithelial cells affected by ovulation. Cancer Letters 191:75-81.
Murdoch WJ, Van Kirk EA, Vonnahme KA, Ford SP 2003 Ovarian responses to undernutrition in pregnant ewes. Reproductive Biology & Endocrinology 1:6.
McDonnel AC, Van Kirk EA, Isaak DD, Murdoch WJ 2003 Inhibitory effects of progesterone on plasma membrane fluidity and tumorigenic potential of ovarian epithelial cancer cells. Experimental Biology & Medicine 228:308-314.
Vonnahme KA, Hess BW, Hansen TR, McCormick RJ, Rule DC, Moss GE, Murdoch WJ,
Nijland MJ, Skinner DC, Nathanielsz PW, Ford SP 2003 Maternal undernutrition
from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy,
and increased liver weight in the fetal sheep. Biology of
McDonnel AC, Van Kirk EA, Austin KJ, Hansen TR, Belden EL, Murdoch WJ 2003
CA-125 expression by progestational bovine endometrium: prospective regulation
and function.
Murdoch WJ, Martinchick JF 2004 Oxidative damage to DNA of ovarian surface epithelial cells affected by ovulation: carcinogenic implication and chemoprevention. Experimental Biology & Medicine 229:553-559.
Schuett GW, Taylor EN, Van Kirk EA, Murdoch WJ 2004 Handling stress and plasma corticosterone levels in male western diamond-backed rattlesnakes (Crotalus atrox). Herpetological Review 35:229-233.
Kiyma Z, Alexander BM, Van Kirk EA, Murdoch WJ, Hallford DM, Moss GE 2004 Effects of feed restriction on reproductive and metabolic hormones in ewes. Journal of Animal Science 82:2548-2557.
Xu P, Tang H, Li S, Ren J, Van Kirk E, Murdoch WJ, Radosz M, Shen Y 2004 Enhanced stability of core-surface cross-linked micelles fabricated from amphiphilic brush copolymers. Biomacromolecules 5:1736-1744.
Schuett GW, Grober MS, Van Kirk EA, Murdoch WJ 2004 Long-term sperm storage and plasma sex steroid profiles of pregnancy in a western diamond-backed rattlesnake (Crotalus atrox). Herpetological Review 35:328-333.
McDonnel
AC, Van Kirk EA, Isaak DD, Murdoch WJ 2005 Effects of progesterone on ovarian
tumorigenesis in xenografted mice. Cancer
Letters 221:49-53.
McDonnel Smedts A, Curry TE, Murdoch WJ 2005 Proteolytic enzymes and their inhibition in epithelial ovarian cancer. Current Enzyme Inhibition 1:157-170.
Murdoch WJ, Van Kirk EA, Alexander BM 2005 DNA damages in ovarian surface epithelial cells of ovulatory hens. Experimental Biology & Medicine 230:429-433.
Schuett GW, Hardy DL, Greene HW, Earley RL, Grober MS, Van Kirk EA, Murdoch WJ 2005 Sympatric rattlesnakes with contrasting mating systems show differences in seasonal patterns of plasma sex steroids. Animal Behaviour 70:257-266.
Murdoch
WJ 2005 Carcinogenic potential of ovulatory genotoxicity.
Biology of
Yang X, Thomas DP, Zhang X, Culver BW, Alexander BM, Murdoch WJ, Rao MNA, Tulis DA, Ren J, Sreejayan N 2006 Curcumin inhibits PDGF-stimulated smooth muscle function and injury-induced neointima formation. Arteriosclerosis, Thrombosis, and Vascular Biology 26:85-90.
Xu P, Van Kirk EA, Li S, Murdoch WJ, Ren J, Hussain MD, Radosz M, Shen Y 2006 Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy. Colloids & Surfaces: Biointerfaces 48:50-57.
Murdoch WJ, Van Kirk EA, McDonnel Smedts A 2006 Complement-inhibiting effect of ovarian cancer antigen CA-125. Cancer Letters 236:54-57.
Xu P, Van Kirk EA, Murdoch WJ, Zhan Y, Isaak DD, Radosz M, Shen Y 2006 Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles. Biomacromolecules 7:829-835.
Schuett GW, Repp RA, Taylor EN, DeNardo DF, Earley RL, Van Kirk EA, Murdoch WJ 2006 Winter profile of plasma sex steroid levels in free-living male western diamond-backed rattlesnakes. General & Comparative Endocrinology 149:72-80.
Xu P, Li S, Li Q, Ren J, Van Kirk EA, Murdoch WJ, Radosz M, Shen Y 2006 Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes. Biotechnology & Bioengineering 95:893-903.
Alexander BM, Van Kirk EA, Naughton LMA, Murdoch WJ 2007 Ovarian morphometrics in TP53-deficient mice. Anatomical Record 290:59-64.
Gotfredson GS, Murdoch WJ 2007 Morphologic responses of the mouse ovarian surface epithelium to ovulation and steroid hormonal milieu. Experimental Biology & Medicine 232:277-280..
Xu P, Van Kirk EA, Zhan Y, Murdoch WJ, Radosz M, Shen Y 2007 Targeted charge-reversal nanoparticles for nuclear drug delivery. Angewandte Chemie International 46:4999-5002.
Jin W, Xu P, Zhan Y, Shen Y, Van Kirk EA, Alexander B, Murdoch WJ, Liu L, Isaak DD 2007 Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(β-aminoester)-graft-PEG for cancer chemotherapy. Drug Delivery 14:279-286.
Wang N, Dong A, Tang H, Van Kirk EA, Johnson PA, Murdoch WJ, Radosz M, Shen Y. 2007 Synthesis of degradable functional polyethylene glycol analogs as versatile drug delivery carriers. Macromolecular Bioscience 7:1187-1198.
Xu P, Li SY, Li Q, Van Kirk EA, Ren J, Murdoch WJ, Zhang ZJ, Radosz M, Shen Y 2008 Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery. Angewandte Chemie International 47:1260-1264.
Shen Y, Tang H, Radosz M, Van Kirk EA, Murdoch WJ 2008 pH-responsive nanoparticles for cancer drug delivery. Methods in Molecular Biology 437:183-216.
Murdoch WJ 2008 Ovulatory factor in ovarian carcinogenesis. Advances in Experimental Medicine & Biology 622:119-128.
Shen Y, Zhan Y, Van Kirk EA, Murdoch WJ, Radosz M 2008 Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer chemotherapy. AIChE Journal 54:2979-2989.
Murdoch WJ, Van Kirk EA, Isaak DD, Shen Y 2008 Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cells and xenografts. Gynecologic Oncology 110:251-255.
Murdoch WJ, Van Kirk EA, Shen Y 2008 Pathogenic reactions of the ovarian surface epithelium to ovulation, dimethylbenzanthracene, and estrogen are negated by vitamin E. Reproductive Sciences 15:839-845.
Shen Y, Tang H, Zhan Y, Van Kirk EA, Murdoch WJ 2009 Degradable poly(β-amino ester) nanoparticles for cancer cytoplasmic drug delivery. Nanomedicine 5:192-201.
Murdoch WJ, McDonnel AC 2009 Ovulation and ovarian surface epithelial cancer. In: Ovarian Cancer: New Research (Horizons in Cancer Research). A. P. Bardos (ed.). Nova Science Publishers, Hauppauge, NY.
Zhou Z, Shen Y, Tang J, Fan M, Van Kirk EA, Murdoch WJ, Radosz M 2009 Charge-reversal drug conjugate for targeted cancer cell nuclear delivery. Advanced Functional Materials 19:3580-3589.
Purdy PH, Moce E, Stobart R, Murdoch WJ, Moss GE, Larson B, Ramsey S, Graham JK, Blackburn HD 2010 The fertility of ram sperm held for 24 h at 5 degrees C prior to cryopreservation. Animal Reproduction Science 118:231-235.
Shen Y, Jin E, Zhang B, Murphy CJ, Meihua S, Zhao J, Tang J, Fan M, Van Kirk EA, Murdoch WJ 2010 Prodrugs forming high drug-loading multifunctional nanocapsules for intracellular drug delivery. Journal of the American Chemical Society 132:4259-4265.
Tang H, Murphy CJ, Zhang B, Shen Y, Van Kirk EA, Murdoch WJ, Radosz M 2010 Curcumin polymers as anticancer conjugates. Biomaterials 31:7139-7149.
Tang H, Murphy CJ, Zhang B, Shen Y, Sui M, Van Kirk EA, Feng X, Murdoch WJ 2010 Amphiphilic curcumin conjugate-forming nanoparticles as anticancer prodrug and drug carriers: in vitro and in vivo effects. Nanomedicine 5:855-865.
Shen Y, Zhou Z, Sui M, Tang J, Xu P, Van Kirk EA, Murdoch WJ, Fan M, Radosz M 2010 Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery. Nanomedicine 5:1205-1217.
Murdoch WJ, Murphy CJ, Van Kirk EA, Shen Y 2010 Mechanisms and pathobiology of ovulation. Society for Reproduction & Fertility Supplement 67:189-201.
Smith AW, Asa CS, Edwards BS, Murdoch WJ, Skinner DC 2012 Predominant
suppression of FSHβ-immunoreactivity after long-term treatment of intact and
castrate adult male rats with the GnRH agonist deslorelin. Journal of
Neuroendocrinology 24:737-747.
Murphy CJ, Tang H, Van Kirk EA, Shen Y,
Murdoch WJ 2012 Reproductive effects of a pegylated curcumin. Reproductive
Toxicology 34:120-124.
Zhang B, Ma X, Murdoch W, Radosz M, Shen Y 2013
Bioreducible poly(amido amine)s with different branching degrees as gene
delivery vectors. Biotechnology & Bioengineering 110:990-998.
Jin E,
Zhang B, Sun X, Zhou Z, Ma X, Sun Q, Tang J, Shen Y, Van Kirk EA, Murdoch WJ,
Radosz M 2013 Acid active cell-penetrating peptides for in vivo tumor-targeted
drug delivery. Journal of the American Chemical Society 135:933-940.
Long NM, Tuersunjiang N, George LA, Lemley CO, Ma Y, Murdoch WJ, Nathanielsz PW, Ford SP 2013 Maternal nutrient restriction in the ewe from early to midgestation programs reduced steroidogenic enzyme expression and tended to reduce progesterone content of corpora lutea, as well as circulating progesterone in nonpregnant aged female offspring. Reproductive Biology & Endocrinology 11:34.
Zhou Z, Ma X, Tang J, Sui M, Shen Y, Van Kirk EA, Murdoch WJ, Radosz M
2013 Linear-dendritic drug conjugates forming long-circulating nanorods for
cancer drug delivery. Biomaterials 34:5722-5735.