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Zoology and Physiology

College of Arts and Sciences

Donal Skinner

Neuroendocrinology Reproduction Comparative Endocrinology Neuroscience  


Graduate Student; * Undergraduate Student

Refereed Journal Articles:

  1. Smith A, Asa C, Edwards BS, Murdoch WJ, Skinner DC 2012 Predominant suppression of FSHβ-immunoreactivity after long-term treatment of intact and castrate adult male rats with the GnRH agonist deslorelin. J Neuroendocrinol 24(5): 737-47
  2. Alexander BM, Skinner DC, Roselli CE 2011 Wired on steroids: Sexual differentiation of the brain and its role in partner preference. Frontiers in Neuroendocrinology 2, Article 42: 1-11
  3. Taylor AW, Evans NP, Hertz C, Skinner DC 2011 Intra-pituitary administration revisited: Development of a novel in vivo approach to investigate the ovine hypophysis. J Neuroscience Methods 199: 175-182
  4. Dong F, Skinner DC, Wu TJ, Ren J 2011 The heart: a novel GnRH target. J Neuroendocrinol 23(5): 456-63
  5. Albertson A & Skinner DC 2009 A novel animal model to study hot flashes: no effect of GnRH. Menopause 16(5): 1030-1036.
  6. Skinner DC, Albertson AJ, Navratil A, Smith A, Mignot M, Talbott H*, Scanlan-Blake N 2009 GnRH effects outside the hypothalamo-pituitary-reproductive axis. J Neuroendocrinol 21: 282-292
  7. Skinner DC 2009 Rethinking the stalk effect: A new hypothesis explaining suprasellar tumor-induced hyperprolactinemia. Medical Hypotheses 72: 309-310
  8. Skinner DC, Lang AL, Pahl L*, Wang Q* 2009 Substance P-immunoreactive cells in the ovine pars tuberalis. Neuroendocrinology 130: 3-8
  9. Caraty A & Skinner DC 2008 Gonadotropin-releasing hormone in third ventricular cerebrospinal fluid: endogenous distribution and exogenous uptake. Endocrinology 149: 5227-5234
  10. Albertson AJ, Navratil A, Mignot M, Dufourny L, Cherrington B, Skinner DC 2008 Immunoreactive GnRH type I receptors in the mouse and sheep brain. J Chem Neuroanat 35: 326-333
  11. Albertson A, Wang Q*, Talbott H*, Jensen D & Skinner DC 2008 The gonadotropin releasing hormone type I receptor is expressed in the mouse cerebellum. The Cerebellum 7: 379-384
  12. Bliss SP, Navratil A, Breed M, Skinner DC, Clay CM & Roberson MS 2007 Signaling complexes associated with the type I GnRH receptor: Colocalization of ERK2 and GnRH receptor within lipid rafts. Mol Endocrinol 28: 531-549
  13. Lutz L, Schofield N*, Crowe C*, Dufourny L & Skinner DC 2007 No effect of nutrient restriction from gestational days 28 to 78 on immunocytochemically detectable growth hormone-releasing hormone (GHRH) neurons and GHRH receptor colocalization in somatotropes of the ovine female fetus. J Chem Neuroanat 33: 34-41
  14. Lutz L, Dufourny L & Skinner DC 2006 Effect of nutrient restriction on the somatotropes and substance P-immunoreactive cells in the pituitary of the female ovine fetus. Growth Horm IGF Res. 16: 108-18
  15. Dufourny L, Caraty A, Clarke IJ, Robinson JE & Skinner DC 2005 Progesterone-receptive dopaminergic and NPY neurons in the arcuate nucleus project to regions of high density GnRH neurons in the ovine preoptic area. Neuroendocrinology 82: 21-31
  16. Dufourny L & Skinner DC 2005 Immunocytochemical colocalization of galanin receptor 1 (GAL-R1) in GnRH neurons in the ovine hypothalamus: Effect of sex, season and oestrous cycle Brain Res 1054: 73-81
  17. Dufourny L, Caraty A, Clarke IJ, Robinson JE & Skinner DC 2005 Progesterone-receptive b-endorphin and dynorphin B neurons in the arcuate nucleus project to regions of high density GnRH neurons in the ovine preoptic area. Neuroendocrinology 81: 139-149
  18. Skinner DC & Dufourny L 2005 Estrogen receptor b expression in the ovine hypothalamus: Distribution and colocalization with GnRH J Neuroendocrinol 17: 29-39
  19. Mignot M & Skinner DC 2005 Colocalization of GH, TSH and prolactin, but not ACTH, with bLH-immunoreactivity: evidence for pluripotential cells in the ovine pituitary. Cell Tiss Res 319: 413 - 421
  20. Dufourny L, Schofield N* & Skinner DC 2003 Galanin expression in ovine GnRH neurons: no effects of gender or reproductive status. J Neuroendocrinol 15: 1062-1069
  21. Skinner DC & Caraty A 2003 Prolactin release during the estradiol-induced LH surge in ewes: modulation by progesterone but no evidence for prolactin-releasing peptide involvement. J Endocrinol 177: 453-460
  22. Scanlan N, Dufourny L & Skinner DC 2003 Somatostatin-14 neurons in the ovine hypothalamus: colocalization with estrogen receptor a and somatostatin-28(1-12) immunoreactivity, and activation in response to estradiol. Biol Reprod 69: 1318-1324
  23. Vonnahme KA, Hess BW, Hansen TR, McCormick R, Rule DC, Moss GE, Murdoch WJ, Nijland M, Nathanielsz PW, Skinner DC & Ford SP 2003 A constant 50% nutrient restriction from day 28 to 78 of gestation in ewes markedly reduces fetal growth rate in association with bilateral ventricular hypertrophy. Biol Reprod 69: 133-140
  24. Dufourny L & Skinner DC 2003 Colocalization of progesterone receptors and thyroid hormone receptors a in the ovine diencephalon: no effect of estradiol. Neuroendocrinology 77: 51-58
  25. Skinner DC, Head S* & Oliver J* 2003 Growth hormone-releasing hormone neurones in the cat do not express progesterone receptors. Cell Tissue Res. 311: 267-270
  26. Skinner JD, Moss DG* & Skinner DC 2003 Inherent seasonality in the breeding seasons of African mammals: evidence from captive breeding. Trans Roy Soc Sth Afr 57: 25-34
  27. Dufourny L & Skinner DC 2002 Progesterone receptor, estrogen receptor a and the type II glucocorticoid receptor are coexpressed in the same neurons of the ovine preoptic area and arcuate nucleus: a triple immunolabeling study. Biol Reprod. 67: 1605-1612
  28. Foradori CD, Coolen LM, Fitzgerald, ME, Skinner DC, Goodman RL & Lehman, MN 2002 Coexpression of progesterone receptors in parvicellular dynorphin neurons of the ovine preoptic are and hypothalamus. Endocrinology. 143: 4366-4374
  29. Skinner DC, Cilliers SD & Skinner JD 2002 The effect of ram introduction on the oestrous cycle of springbok ewes (Antidorcas marsupialis). Reproduction. 124: 509-513
  30. Dufourny L & Skinner DC 2002 Type II glucocorticoid receptors in the ovine hypothalamus: distribution, influence of estrogen and absence of colocalisation with GnRH. Brain Res. 946: 79-86
  31. Dufourny L & Skinner DC 2002 Influence of estradiol on NADPH diaphorase/neuronal nitric oxide synthase activity and colocalization with progesterone- or type II glucocorticoid-receptors in the ovine hypothalamus. Biol Reprod. 67: 829-836
  32. Skinner DC & Caraty A 2002 The measurement and possible function of GnRH in cerebrospinal fluid in ewes. Reproduction Suppl 59: 25-39
  33. Malpaux B, Tricoire H, Daveau A, Locatelli A, Chemineau P & Skinner DC 2002 Melatonin and seasonal reproduction: understanding the neuroendocrine mechanisms using the sheep as a model. Reproduction Suppl 59: 167-179
  34. Evans NP, Richter TA, Skinner DC, Robinson JE 2002 On the neuroendocrine mechanisms of GnRH surge induction by estradiol. Reproduction Suppl 59: 57-66
  35. Goodman RL, Gibson M, Skinner DC & Lehman MN 2002 Neuroendocrine control of pulsatile GnRH secretion during the ovarian cycle: Evidence from the ewe. Reproduction Suppl 59: 41-56
  36. Scanlan N & Skinner DC 2002 Estradiol modulation of growth hormone secretion in the ewe: no growth hormone-releasing hormone neurons and few somatotropes express estradiol receptors. Biol Reprod. 66: 1267-1273
  37. Skinner DC, Caraty A & Allingham R 2001 Unmasking the progesterone receptor in the preoptic area and hypothalamus of the ewe: no colocalization with GnRH neurons. Endocrinology. 142: 573-579
  38. Skinner DC, Richter TA, Malpaux B & Skinner JD 2001 Annual ovarian cycles in an aseasonal breeder, the springbok (Antidorcas marsupialis) Biol Reprod. 64: 1176-1182
  39. Skinner JD & Skinner DC 2001 Significance of aseasonal breeding in arid adapted antelope in southern Africa. Ecology of Desert Environments pages 391-403
  40. Richter TA, Spackman DS*, Robinson JE, Dye S, Harris TG, Skinner DC & Evans NP 2001 Role of endogenous opioid peptides in mediating progesterone-induced disruption of the activation and transmission stages of the GnRH surge induction process. Endocrinology 142: 5212-5219
  41. Skinner DC, Harris TG & Evans NP 2000 Duration and amplitude of the luteal phase progesterone increment times the estradiol-induced LH surge in ewes. Biol Reprod 63: 1135-1142
  42. Chabbert-Buffet N, Skinner DC, Caraty A & Bouchard P 2000 Neuroendocrine actions of progesterone. Steroids 65: 613-620
  43. Robinson JR, Healey AE, Harris TG, Messent AE, Skinner DC, Taylor JA & Evans NP 2000 The negative feedback action of progesterone on luteinizing hormone release is not associated with changes in GnRH mRNA expression in the ewe J Neuroendocrinol 12: 121-130
  44. Skinner DC, Bouchard P & Caraty A 1999 The progesterone blockade of the luteinizing hormone surge is overcome by RU486. J Neuroendocrinol 11: 637-643.
  45. Skinner DC & Malpaux B 1999 High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus. Endocrinology 140: 4399-4405.
  46. Caraty A & Skinner DC 1999 Progesterone is essential for the full expression of the positive feedback effect of estradiol in inducing the preovulatory GnRH surge in the ewe. Endocrinology 140: 165-170.
  47. Caraty A & Skinner DC 1999 Dynamics of steroid regulation of GnRH secretion during the estrous cycle of the ewe. Annales d'Endocrinologie 60: 68-78.
  48. Harris TG, Dye S, Robinson JE, Skinner DC & Evans NP 1999 Progesterone can block the transmission of the estradiol-induced signal for LH surge generation during a specific period of time immediately after activation of the GnRH surge generating system. Endocrinology 140: 827-834.
  49. Skinner DC 1998 Org-31806. IDrugs 1: 350-354.
  50. Harris TG, Robinson JE, Evans NP, Skinner DC & Herbison AE 1998 Gonadotropin-releasing hormone mRNA expression changes prior to the onset of the estradiol-induced LH surge in the ewe. Endocrinology 139: 57-64.
  51. Skinner DC, Caraty A & Evans NP 1998 Does gonadotropin-releasing hormone in the cerebrospinal fluid modulate luteinizing hormone release? Neuroendocrinology 67: 37-44.
  52. Skinner DC, Evans NP, Bouchard P, Delaleu B & Caraty A 1998 The negative feedback actions of progesterone on gonadotropin-releasing hormone secretion are transduced by the classical progesterone receptor. Proc Natl Acad Sci 95: 10978-10983.
  53. Caraty A, Skinner DC, Huyge B, Berthault T, Picard S, Delaleu B, Malpaux B & Thiery JC 1998 GnRH increase following progesterone withdrawal in the ovariectomised (OVX) ewe is associated to an increase in the glutamaergic tone in the preoptic area (POA). Ann NY Acad Sci 839: 363-364.
  54. Skinner DC & Herbison AE 1997 Effects of photoperiod on estrogen receptor, tyrosine hydroxylase, neuropeptide Y and b-endorphin immunoreactivity in the ewe hypothalamus. Endocrinology 138: 2585-2595.
  55. Skinner DC & Robinson JE 1997 Luteinising hormone secretion from the perifused ovine pars tuberalis and pars distalis: effects of melatonin and LH-releasing hormone. Neuroendocrinology 66: 263-270.
  56. Skinner DC, Evans NP & Malpaux B 1997 Does a shortloop feedback mechanism for the control of luteinizing hormone secretion exist in the ewe? Endocrinology 138: 4220-4226.
  57. Skinner DC, Caraty A, Malpaux B & Evans NP 1997 Simultaneous measurement of GnRH in the third ventricular cerebrospinal fluid and hypophyseal portal blood of the ewe. Endocrinology 138: 4699-4704.
  58. Malpaux B, Viguié C, Skinner DC, Thiéry JC & Chemineau P 1997 Control of the circannual rhythm of reproduction by melatonin in the ewe. Brain Res Bull 44: 431-438.
  59. Robinson JE, Skinner DC, Skinner JD & Haupt MA 1997 Distribution of LHRH neurones in the springbok (Antidorcas marsupialis). J Comp Neurol 389: 444-452.
  60. Skinner DC & Robinson JE 1996 The pars tuberalis of the ewe: no effect of season or ovariectomy on the distribution, density or presence of immunoreactive cells. Cell Tiss Res 284: 117-123.
  61. Herbison AE, Skinner DC, Robinson JE & King I 1996 Androgen receptor- immunoreactive cells in ram hypothalamus: Distribution and co-localization patterns with gonadotrophin-releasing hormone, somatostatin and tyrosine hydroxylase. Neuroendocrinology 63: 120-131.
  62. Malpaux B, Viguié C, Skinner DC, Thiéry JC, Pelletier J & Chemineau P 1996 Seasonal breeding in sheep: mechanism of action of melatonin. Anim Reprod Sci 42: 109-117.
  63. Skinner DC & Robinson JE 1995 Melatonin-binding sites in the gonadotroph- enriched zona tuberalis of ewes. J Reprod Fert 104: 243-250.
  64. Skinner DC, Malpaux B, Delaleu B & Caraty A 1995 Luteinizing hormone-releasing hormone in third ventricular cerebrospinal fluid of the ewe: correlation with luteinizing hormone pulses and the LH surge. Endocrinology 136: 3230-3237.
  65. Malpaux B, Skinner DC & Maurice F 1995 The ovine pars tuberalis does not appear to be targeted by melatonin to modulate luteinising hormone secretion, but may be important for prolactin release. J Neuroendocrinol 7: 199-206.
  66. Van Aarde RJ, van der Merwe M & Skinner DC 1994 Progesterone concentrations in the plasma, ovary, adrenal gland and placenta of the pregnant natal clinging bat, Miniopterus schreibersii natalensis. J Zool Lond 232: 457-464.
  67. Herbison AE, Robinson JE & Skinner DC 1993 Distribution of estrogen receptor- immunoreactive cells in the preoptic area of the ewe: Co-localization with glutamic acid decarboxylase but not luteinizing hormone-releasing hormone. Neuroendocrinology 57: 751-759.
  68. Herbison AE, Robinson JE & Skinner DC 1993 Calcitonin gene-related peptide (CGRP): Immunocytochemical identification of a neuropeptide synthesised by ventral paraventricular magnocellular neurones in the sheep. Brain Res 611: 147-151.
  69. Skinner DC, Herbison AE & Robinson JE 1992 Immunocytochemical identification of oestrogen receptors in the ovine pars tuberalis: Localisation within gonadotrophs. J Neuroendocrinol 4 : 659-662.
  70. Allanson BR, Skinner DC & Imberger J 1992 Flow in prawn burrows. Est Coast Shelf Sci 35: 253 - 266.
  71. Skinner DC, Moodley G & Buffenstein R 1991 Is vitamin D3 essential for mineral metabolism in the Damara mole-rat (Cryptomys damarensis)? Gen Comp Endocrinol 81: 500 -505.
  72. Skinner DC 1991 Effect of intraperitoneal melatonin injections on thermoregulation in the Transvaal girdled lizard, Cordylus vittifer. J Therm Biol 16: 179 - 184.
  73. Buffenstein R, Skinner DC, Yahav S, Moodley G, Cavaleros M, Zachen D, Ross FP & Pettifor J 1991 The effect of oral cholecalciferol supplementation at physiological and supraphysiological doses in naturally D3-deplete subterranean mole-rats (Cryptomys damarensis). J Endocrinol 131: 197 - 202.
  74. Van Aarde RJ, Skinner JD, Knight MH & Skinner DC 1988 The use of space by a striped hyaena Hyaena hyaena in the Negev Desert. J Zool Lond 216: 575 - 577.

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