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Zoology and Phsyiology|College of Arts and Sciences

Joan Smith Sonneborn PhD
Professor Emerita


Email:cancun@uwyo.edu
Phone: 307 742 4728
FAX: 307 745 3139

Publications
1.      Smith Sonneborn J. 2010. Mimetics of hormetic agents: Stress-Resistance triggers. Dose Response, in press.

2.      Smith Sonneborn J. 2009 Epigenetic role in longevity echoes conserved stress survival strategies  In Epigenetics: Mechanisms, Foundations, and Human Effects. Eds: Balázs Pintér  and Zsolt Mézáros. ,Nova Science Publishers, in press.

3.      Smith Sonneborn J. 2008.Hormetic triggers for intervention in aging, disease, and trauma. Amer. J Pharmacology and Toxicology, 3 1-10.

4.      Rutten, M.R. , M. Govindaswami, P. Oeltgen & J. Smith Sonneborn . 2008. Post treatment with the novel Deltorphin -E, a δ2 opioid receptor agonist, increases recovery and survival after severe hemorrhagic shock in behaving rats. Shock: 2008  29:42-48.

5.      Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chiueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, Feinendegen L, Gardner DE, Hart RW, Hastings KL, Hayes AW, Hoffmann GR, Ives JA, Jaworowski Z, Johnson TE, Jonas WB, Kaminski NE, Keller JG, Klaunig JE, Knudsen TB, Kozumbo WJ, Lettieri T, Liu SZ, Maisseu A, Maynard KI, Masoro EJ, McClellan RO, Mehendale HM, Mothersill C, Newlin DB, Nigg HN, Oehme FW, Phalen RF, Philbert MA, Rattan SI, Riviere JE, Rodricks J, Sapolsky RM, Scott BR, Seymour C, Sinclair DA, Smith-Sonneborn J, Snow ET, Spear L, Stevenson DE, Thomas Y, Tubiana M, Williams GM, Mattson MP.  2007. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Appl Pharmacol. Toxicol . 2007; 222(1):122-8.

6.      Smith Sonneborn,  Joan  2005. Myth and reality of reversal of aging by hormesis. Ed. Walter Pierpaoli. Ann NY Academy Science,  1057:165-176.

7.      McBride, S. M., J. Smith Sonneborn, P. Oeltgen & F. W. Flynn. 2005.  Delta2 opioid receptor agonist facilitates mean arterial pressure recovery after hemorrhage in conscious rats.  Shock 23: 264-268.

8.      Smith Sonneborn J., H. Gottsch, E. Cubin, P. Oeltgen & P. Thomas. 2004. Alternative strategy for stress tolerance: opioids.  J Gerontol. 59: 433-40.

9.      Smith Sonneborn, J. and  S. Barbee, 1998 Exercise-induced stress response as an adaptive tolerance strategy. Environ Health Perspective 106: 325-330.

10.   Thomas J. and  J. Smith Sonneborn. 1997. Supplemental melatonin increases clonal  lifespan in the protozoan Paramecium tetraurelia. J Pineal Res. 23: 123-130.

11.   Smith Sonneborn J. & H, McGinley 1997 Physiological and Psychological Changes associated with an aerobic weight lifting circuit. Senior Fitness Association 16: 33-36.

12.   Smith-Sonneborn, J. M.Stansbury and J. Thomas 1996. Induced hydrogen peroxide tolerance in  Paramecium. Eur. J. Protistol. 32: Suppl. 153-157.

13.   Smith-Sonneborn 1989. Protozoa. In: Non-mammalian Animal Models for Biomedical Research Vol.2 CRC Press, Boca Raton,FL.

14.   Smith Sonneborn, J. 1992. The role of the stress response in hormesis. In Low Dose Irradiation and Biological Defense Mechanisms. (Sugahara T, L.A. Sagan, T. Aoyama eds.) Exerpta Medica, pp.399-404 Elsevier Publishers, Amsterdam.

15.   Smith-Sonneborn 1992. The role of the "stress response" in hormesis In: Biological Effects of Low Level Exposures to Chemicals and Radiation (E. Calabrese ed) pp 41-53. Lewis Pub, Chelsea, MI.

16.   Smith-Sonneborn, J. Protozoa In: Review of Biological Research in Aging Vol 4 (G. Martin ed) Alan Liss, NY.

17.   Smith Sonneborn, J. 1990. Aging in Protozoa. In: Handbook of Biology of Aging. (Schneider, EL. and Rowe, J. eds) pp 22-44 Academic Press NY.

18.   Leibovitz, B. and J. Smith-Sonneborn. 1988. A method of lipid peroxidation in Paramecium. Age 11:128-134.

19.   Leibovitz, B. and J. Smith-Sonneborn. 1988. A method of lipid peroxidation in Paramecium. Age 11:128-134.

20.   Smith-Sonneborn, J. 1987. Longevity in the Protozoa. In:Evolution of Longevity in Animals: A comparative approach. (A.D. Woodhead and K.H. Thompson,eds,) pp101-110. Basic Life Sciences. Vol Plenum Publ NY, NY

21.   Smith-Soneborn J. 1987. Error Catastrophe In Modern Biological Theories (H.R. Warner, R.N. Butler, R.L. Sprott and E.L. Schneider, eds) pp133-134, 169-175. Raven Press NY, NY.

22.   Smith-Sonneborn, J., 1987. Aging in protozoan In: Review of Biological Research in Aging. Volume 3 (M. Rothstein ed,) pp 32-40. Alan Liss NY,

23.   Smith-Sonneborn, J., 1987. Aging in protozoan In: Review of Biological Research in Aging. Volume 3 (M. Rothstein ed,) pp 32-40. Alan Liss NY,

24.   Smith-Sonneborn, J., B. Leibovitz, R. Donathan and G.L. Fisher. 1986. Bioassay of environmental nickel dusts in a particle feeding ciliate. Environ.Mut. 8: 621-627

25.   Smith-Sonneborn J. 1985. Protozoa. In: Nonmammalian models for research on aging. pp 201-230. (F.L. Lints,ed) Karger-Basel Pub. Switzerland.

26.   Smith-Sonneborn, J. 1985. Aging in Protozoa. In: Review of Biological Research in Aging Vol 2 pp.13-28 ( M. Rothstein ed.) Alan R. Liss Inc. NY.

27.   Dihel, L.E. and J. Smith-Sonneborn. 1985. Effects of low frequency electromagnetic field in cell division rate and plasma membrane. Bioelectromagnetics. 6:61-71,

28.   Dihel, L.E. and J. Smith-Sonneborn. 1985. Effects of low frequency electromagnetic field in cell division rate and plasma membrane. Bioelectromagnetics. 6:61-71,

29.   Smith-Sonneborn, J. Genome interaction in the pathology of aging. In: Handbook of Cell Biology ( V. Cristofalo, ed.) pp.453-480. CRC Press, Boca Raton, FL.

30.   Smith-Sonneborn, J. 1985. Aging in unicellular organisms. Handbook of Biology, 2nd Edition (C.E. Finch and E.L. Schneider, eds.) pp. 79-99, Van Nostrand Reinhold Co.NY, NY.

31.   Smith-Sonneborn, J., P.D. Lipetz and R.E. Stephens. 1984. Novobiocin inhibition of dark repair and longevity in Paramecium. In: DNA Repair and its Inhibition. Nucleic Acid Symposium Series, IRL. Pp 309-318.

32.   Smith- Sonneborn J. 1984. "Protozoan aging" In Selected Invertebrate Models for Aging Research (D. Mitchell and T. Johnson eds.) pp2-14. CRC Press Boca Raton FL.

33.   Smith-Sonneborn, J. 1983. Programmed increased longevity by weak pulsating current in Paramecium. Bioelectrochem and Bioenerg. 11:373-382.

34.   Smith-Sonneborn, J., 1983. Use of ciliated protozoan as a model system to detect toxic and carcinogenic agents.  In: In Vitro toxicity testing of environmental agents.Part A" (A.R. Kolber, T.K. Wong,L.D. Grant, R.S. DeWoskin and T.J. Hughes eds.) pp113-137. Plenum Publishing NY,NY.

35.   Smith-Sonneborn J., P.D. Lipetz and R.E. Stephens, 1983. Paramecium bioassay of longevity modulating agents. In: Intervention in the aging process: Basic Research, Clinical Screening and Clinical Programs (W. Regelson and F.M. Sinex eds. pp253-272 Alan Liss Inc.NY, NY)

36.   Smith-Sonneborn, J., 1983. Aging in protozoa In:Review of Biological Research in Aging Vol 1. Pp 29-35 (M.Rothstein,ed ) Alan Liss Inc. NY,NY.

37.   Smith-Sonneborn, J., R.A.Palizzi, and E.A. McCann 1983.  Bioassay of oil shale process waters in Paramecium and Salmonella. In: Short-term bioassays in analysis of complex environmental mixtures. III (M.Waters, SS Sandhu, J. E. Lewis L.Claxton, W. Chernoff and S. Nesnow, eds.) pp197-210 Plenum Pub NY.

38.   Smith-Sonneborn, J., R.A. Palizzi, E.A. McCann and G.L. Fisher. 1983. Bioassay of genotoxic effects of environmental particles in a feeding ciliate. Environ. Health Perspectives 51:205-210.

39.   Smith-Sonneborn, J. G.L. Fisher, R.A. Palizzi and C Herr. 1981. Mutagenicity of coal fly ash: A new bioassay for mutagenic potential in a particle feeding ciliate. Environmental Mutagenesis 3: 239-352

40.   Smith-Sonneborn, J. 1981. Genetics and aging in protozoa. Int. Rev. Cytology 73:319-354.

41.   Heifetz, S.R. and J. Smith-Sonneborn. 1981. Nuclear changes in aging and autogamous Paramecium tetraurelia: Quantitative and morphological aspects. Mech Aging and Devel. 255-263

42.   Smith-Sonneborn J., R.A. Palizzi, C.A. Herr and G.L. Fisher. 1981. Particle mediated mutagenicity of coal fly ash. Environ. Mut. 3: 239-252.

43.   Smith-Sonneborn, J., R.A. Palizzi, C.A. Herr, and G.L. Fisher. 1981. Mutagenicity of fly ash. Science 211:180-182.

44.   Williams T. and J. Smith Sonneborn. 1980. DNA polymerase activity in aged clones of . Paramecium. Exp. Gerontol. 15:353-357.

45.   Williams, T. and J. Smith Sonneborn. 1980. The malic dehydrogenase locus of Paramecium tetraurelia. Biochem. Genetics 18:389-399.

46.   Smith-Sonneborn, J. 1979. DNA repair and Longevity assurance in Paramecium tetraurelia. Biochem. Genetics 8:389-399.

47.   Hart, R.W. D. Brach and J. Smith-Sonneborn. 1979. Aging in paramecia and man. Conference on Structural pathology on DNA and biology of aging "In: Deutsche Fortschungagemein, Freiburg, Germany.

48.   Hart, R.W. and J. Smith-Sonneborn. 1979. Molecular mechanisms of aging and carcinogenesis.  Excerpta Medica XI. Internatl. Congress Gerontology, Tokyo Japan

49.   Smith-Sonneborn  J.  1979. DNA repair and longevity assurance in Paramecium

       tetraurelia. Science 203:1115-1117.

50.   Smith Sonneborn, J. 1978. What determines life span? Symposium Japanese Medical Association. Hakone, Japan.

51.   Rodermel, S. and J. Smith Sonneborn 1977. Age-correlated changes in expression of micronuclear damage and repair. Genetics 87:259-274.

52.   Smith-Sonneborn, J. and S. Rodermel. 1976. Loss of endocytic capacity in aging Paramecium: The importance of cytoplasmic organelles  J. Cell Biol. 71:575-588.

53.   Klass, M., and J. Smith-Sonneborn. 1976. Studies on DNA content, RNA synthesis, and DNA template activity in aging cells of Paramecium aurelia. Exp. Cell Res. 98:63-72.

54.   Smith-Sonneborn, J. and J. Reed. 1976. Calendar life span versus fission life span. J. Gerontology 31: 2-7.

55.   Smith-Sonneborn J. 1974. Acridine orange fluorescence: a temporary stain for Paramecium. Stain Tech. 49:79-80.

56.   Smith-Sonneborn, J. and M. Klass. 1974. Changes in DNA synthesis pattern of Paramecium with increased clonal age and interfission time J. Cell Biol. 61: 591-598.

57.   Smith-Sonneborn, J. M. Klass and D. Cotton. 1974. Parental age and life span versus progeny life span in Paramecium.  J. Cell Science 14: 691-699.

58.   Smith-Sonneborn, J. 1974. Age-correlated effects of caffeine on non-irradiated Paramecium aurelia. J.Gerontol. 29:256-260.

59.   Smith-Sonneborn J. 1971. Age correlated sensitivity to ultraviolet radiation in Paramecium. Rad. Res. 46:64-69.

60.   Smith-Sonneborn, J. 1970. Protozoa: Ciliates 70. Report NIH .Invertebrate Model Systems for Aging Research

61.   Smith-Sonneborn, J. and W. Plaut. 1969. Studies on the autonomy of pellicular DNA in Paramecium J. Cell Sci. 5:365-372.

62.   Smith Sonneborn, J. and W. Plaut. 1967.  Evidence for the presence of DNA in the pellicle of Paramecium J. Cell Science 21:225-234.

63.   Smith-Sonneborn, J.E. and W.J. van Wagtendonk 1964. Purification and chemical characterization of kappa of Stock 51 Paramecium aurelia. Exptl. Cell Res. 33: 50-59

64.   Smith-Sonneborn,J., L. Green and J. Marmur.1963. Deoxyribonucleic acid base composition of kappa of Stock 51 Paramecium tetraurelia.  Nature 197:385.

65.   Schildkraut, C.L., M. Mandel, S. Levisohn, J.E. Smith Sonneborn and J. Marmur. 1962. Deoxyribonucleic acid base composition and taxonomy of some protozoa. Nature 196:795-796.

 Presentations
1.      Smith Sonneborn, J. 2009 Mimetics of Hormetic Agents:Stress Resistance Triggers;62 GSA Annual Meeting, Atlanta, Georgia, 11/18-11/22.

2.       Smith Sonneborn, J. 2009 Mimetics of Hormetic Agents Offer Interventions in Aging, Disease, and Trauma,

The 8th Annual International Conference: Dose-Response: Implications for Toxicology, Medicine and Risk Assessment, April 28 - 29, 2009, at the University of Massachusetts Amherst

3.      Smith Sonneborn, J. 2009 Panel Interprofessional Seminar on Sexuality and Aging Feb 13 University of Wyoming, Laramie

4.      Smith Sonneborn, 2008 Activation of Ancient Latent Stress-resistance Pathways by Molecular Triggers; Age and Disease InterventionSecond World Ehrlich II Conference on Magic Bullets, Nurenburg , Germany, Oct 3-5

5.      Smith Sonneborn J 2007 Exercise and Wellness Governor's Conference on Aging Casper WY May2-4.

6.      McNiven K and Smith Sonneborn 2006  Hot Poster Effects of H2 Receptor Antagonists on Heat Stress Survival in Conscious Rats 59th Annual GSA Meeting November Dallas Texas.

7.      Smith Sonneborn J. 2005 Symposium: Pharmaceutical Intervention in Heat Stroke 58th Annual Meeting GSA November Orlando FL

8.      Smith Sonneborn J 2005 The Myth and Reality of Reversal of AGING By Hormesis.  Fourth Stromboli Conference Stromboli Italy June 6-11

9.      Gottsch H. Nemick S, Smith Sonneborn Hot Poster Effect of  Hibernation in Bears on Expression of Ubiquitin and IGF1 m RNA 2004 57th Annual GSA Conference November Washington DC

10.   Smith Sonneborn, J 2003 Biological Basis of Rejuvenating Effects of Strength Training especially in Women 56th Annual Meeting GSA San Diego CA Nov 21-25,

11.   Smith Sonneborn J. 2003. Health Promoters III Congresso Paramericano de Gerontologia April 30-May 3, Mar del Plata Argentina

12.   Smith Sonneborn J. 2003 Rejuvenation Effects of Exercise Governors Conference on Aging. Cheyenne WY

13.   Smith Sonneborn, Joan Symposium Organizer Muscle Strength: Hibernation and Exercise Intervention Strategies: Henry J. Harlow, Peter Oeltgen. Joan Smith Sonneborn, Maria Fiatarone Singh Gerontological Society of America  55th Annual Meeting, Boston, 2002

14.   Smith Sonneborn, Joan Symposium Organizer Biological Implications of Sex on Human Health Joan Smith Sonneborn, Shiriki Kumanyika, Barbara Ann Gilchrest, Richard Hodes, Gerontological Society of America, 55th Annual Meeting, Boston, 2002

15.   McBride, S. and Smith Sonneborn Joan Biological Implications of Sex on Human Health Hot Poster, Gerontological Society of America, 55th Annual Meeting, Boston 2002.

16.   Smith Sonneborn Joan Symposium Organizer  Sex Matters Promise of Productive Aging Terri Fox Wettle, Carmon Sapienza,  Caleb Finch, Gerontological Society of America,  54th Annual Meeting, Chicago, 2001

17.   Gottsch, H.,  P. Thomas, P. Oeltgen,  Smith Sonneborn J,  Ubiquitin Stress Response in Rat Heart treated with Hibernating Serum, Gerontological Society of America, 54th Annual Meeting, Chicago, 2001

18.   "Heat Shock Proteins as an Adaptive Response" Toxicological Defense Mechanisms and the Shape of Dose-Response Relationships. National Institute of Environmental Health Sciences, Research Triangle Park, N.C. November 12-14, 1996.

19.   "Exercise and Cardiovascular Health", Promoting Healthy Women and Those They Love, American Heart Association, Colorado/Wyoming Affilitate, April 13, 1996 Casper, Wyoming.

20.   "The Effect of Aerobic Weight Lifting Circuit Training on Cardiovascular Risk Factors and Gene Expression" The 3rd International Conference on Anti-Aging Medicine & Biomedical Technology December 9-11, 1995 Alexis Park Resort, Las Vegas Nevada

21.   "Exercise & Aging" for Documentary Projected for Extreme Performance, London, Laurence Barnett Producer, Filmed March, 1995, Laramie, WY

22.   "Strength at Any Age" The Mind/Body Connection, University of Wyoming Special Programs School of Extended Studies, March 18, 1995.

23.   "Exercise Intervention in Cardiovascular Risk Factors" Departmental Seminar, Fall, 1995.

24.   "In Pursuit of Excellence" Senior Lyceum October 3, 1995, Univerity of Wyoming, Laramie WY

25.   "Exercise and Aging" White House Conference on Aging, Cheyenne, WY, Fall, 1994.

26.   "On the Cutting Edge."  "Strategies for Health Maintenance Throughout the Life Cycle" Tuesday, October 18, 1994, Medicine Bow Room, University of Wyoming

27.   "Biology of Aging" keynote speaker at the "Reminiscence Workshop and Chemical Dependency Training Program  October 14, 1994.  Powder River Chemical Dependency, Inc. Gillette, WY.

28.   "The "Stress Protein Response" as a Biomarker of Aging", American Academy of Anti-Aging Medicine, Cancun, Mexico November , 1993.

29.   "Overview of Research in Alzheimer's Disease", Alzheimer's Disease and Related Disorders, Casper, Wyoming, September, 1993.

30.   "The Stress Response to Radiation" Second Annual Belle Conference, Crystal City Gateway Hotel, Arlington, Virginia, April 26-29, 1993.

31.   "The Stress Response and Hormesis" University of  Colorado, Fort Collins, December, 1992

32.   "The Role of the Stress Response in Hormesis", The International  Conference on Low Dose Irradiation and Biological Defense Mechanisms, Kyoto, Japan, July 12-16,1992,

33.   "The Role of the Stress Response in Hormesis", BELLE Conference, Amherst, MA, April 1991.

34.   "Intervention in the Aging Process" Monash Medical Center, Clayton, Melborne, Australia, May, 1990.

35.   "Genetics & Aging" Genetics Department, Monash University , Clayton, Melborne, Australia, April, 1991.

36.   "From Protozoa to Neurobiology", Andrus Center for Gerontological Research, University of Southern California. Jan. 1990.

37.   "Inducible Stress Responses in Ciliates". Gerontological Society of America.  Nov. 17-21, 42nd Annual Meeting, Minneapolis.   

38.   "Intervention in Aging".  Morning of Classes, A & S.  Oct. 13, 1988.

39.   "Hormesis Induced Lifespan Extension in Paramecium", International Association of Gerontology, The World Congress of Gerontology XIV Meeting, June 18, 1989, Acapulco, Mexico.

40.   "Quality of Life.  An Ethical Dilemma: Life vs. Quality of Life.  Keynote speaker.  Sheridan College, Sheridan, WY.  Oct. 5-7.  1988.

41.   "Aging in Protozoa."  U.W. Alumni Association, Sept. 1988.

42.   "Gerontology of the Future Years: Biological Breakthroughs", Institute for National Scientific Research, 5th  Annual Conference, Oct. 10, 1987, Montreal, Quebec.

43.   "Aging in the Next Decade", Zoology and Physiology Departmental Seminar, September 10, 1987.

44.   "Homology Between Yeast and Paramecium DNA Repair Genes", Second International Ciliate Molecular Genetics Conference, August 2-6, 1987, Berkeley, CA.

45.   "Aging in the Next Decade", Rotary Club, Laramie, WY, June 4, 1987.

46.   "How We Age", United States Senate Building, April 28, 1987.

47.   "How We Age", Pre-Medical Society - Alpha Epsilon Delta, April 8, 1987.

48.   "How We Age", Office of Development, March 18, 1987. 

49.   "How We Age", In The Promise of Productive Aging, A Symposium Focus Japan/USA.  Russell Senate Office, U.S. Senate, Washington, DC., 28-29, 1987.

50.   "Longevity in Protozoa in Aging Processes in Animals", Brookhaven Symposium in Biology, No. 34.  Brookhaven National Laboratory, Upton, NY, October 19-22, 1986.

51.   "Biology of Aging", Chair, Gordon Conference, Plymouth, NH, July 21-25, 1986.

52.   "Modern Biological Theories of Aging", Chair - Error Catastrophe, Mount Sinai, NY, June 3-6-, 1986.

53.   "Intervention in Life Span", Panel Lifespan Extension Meeting, Anaheim, CA, May 4, 1986.

54.   "Changing the Aging Process", Rotary Club, Laramie, WY, April 3, 1986.

55.   "Intervention in Life Span", University of California-San Diego, October, 30, 1985.

56.   "Intervention in Life Span", University of California-Los Angeles, October 24, 1985.

57.   "Biology of Aging in the Protozoa", University of Washington, Seattle, Washington, May 13, 1985.

58.   "Clonal Age and Cell-Specific Response to Low Frequency Electromagnetic Fields".  NATO Advanced Research Workshop.  5th Course International School of Pure and Applied Biological Structure, Majorana School, Erice, Sicily, September 17-21, 1984.

59.   "Environment Modulation of Life Span", University of Kebangsaan, Kuala Lampur, Malaysia, August 10, 1984.

60.   "Cell-Specific Stimulation of Division Rate and Survival by Pulsating Low Frequency Electromagnetic Fields (PEMF):, International Society of Electrochemistry, University of California, Berkeley, August 5-8-1984.

61.   "Clonal Age and Cell Specific Response to Low Frequency Electromagnetic Fields", First International Ciliate Molecular Genetics Meeting.  Cold Spring Harbor Laboratory, May 2, 1984.

62.   "Environmental Modulation of Life Span", Idaho State College, Pocatello, Idaho, April 11, 1984.

63.   "Modulation of Life Span", Minot State College.  Minot, ND.  December 7, 1983.

64.   "Altered Survival of Wild Type and Mutant Cells Induced by Weak Pulsating Current", International Symposium in Bioelectrochemistry Bioenergetics, University of Nottingham, School of Agriculture, Nottingham, England, September 4-9, 1983.

65.   "Altered Cell Division Rate and Dye Binding Induced by Weak Pulsating Current", International Symposium, Bioelectrochemistry Bioenergetics, University of Nottingham.  Nottingham, England, September 4-9-1983.

66.   "Programmed Increased Longevity by Weak Pulsating Current in Paramecium", VII International Symposium, Bioelectrochemistry.  Stuttgart, FRG, July 18-22, 1983.

67.   "Biology of Aging", Conference on Sexuality Through the Life Cycle.  Casper, WY, October 18, 1983.

68.   Panelist "Research with a Purpose: The Role of the University in Aging Research Design and Implementation", Planning Conference: Center for Aging and Human Development.  University of Wyoming, Laramie, WY, April 22-23, 1983.

69.   "Environmental Modification of Aging and Genetic Damage", Ohio State University.  Columbus, OH, April 7-8, 1983.

70.   "Environmental Modification of Life Span", North Dakota State University, Fargo, ND, March 23, 1983.

71.   "Cellular Mechanisms in Determination of Life Span, Mutagenesis and Repair", Miami University.  Oxford, OH, March 25, 1983.

72.   "Environmental Modification of Life Span", Fermi National Accelerator Laboratory.  Batavia, IL, December 9, 1982.

73.   "Environmental Modification of Life Span Duration", Mankato State College.  Mankato, MN, November 17, 11982.

74.   "Age Specific Increased Survival Response to Induced Weak Pulsating Current", 35th  Annual Scientific Meeting of The Gerontological Society of America.  Boston, MA, November 19-23, 1982.

75.   "Environmental Modification of Life Span Duration and Genetic Damage".  Mayo Clinic.  Rochester, MN, November 16, 1982.

76.   "Protozoa", FIBER Meetings.  Boston, MA., November 5-6, 1982. 

77.   "Using Paramecia to Identify Agents that Speed Up or Slow Down Aging", FIBER, Rockefeller University.  New York, NY, October 18, 1982.

78.   "Environmental Modification of Life Span Duration and Genetic Damage", Boise State University.  Boise, ID, October 7, 1982.

79.   "The Environmental Modulation of Life Span", Mills Social Science

80.   "Modulation of Longevity", Department of Pathology, University of California.  Los Angeles, CA, July 23, 1982.

81.   "Electromagnetic Modulation of Vitality in Paramecium", 4th Annual Scientific Session of Bioelectromagnetics Society.  Los Angeles, CA, June 28-July 2, 1982.

82.   "Vitality and Aging", Wyoming Governor's Conference on Aging, University of Wyoming.  Laramie, WY, June 1-3, 1982.

83.   "Altered Biological Response in Paramecium Induced by Weak Pulsating Current", The Electrochemical Society 161st Meeting.  Montreal, Canada, May 9-14, 1982.

84.   "Bioassay of Genotoxic Effects of Environmental Particles in a Feeding Ciliate", In Vitro Effects of Mineral Dusts, DeGray State Park, Arkadelphia, AR, April 25-28, 1982.

85.   "Effects of Weak Pulsating Current Vitality in Paramecium", American Chemical Society Meeting.  Las Vegas, NV, March 28-April 2, 1982.

86.   Chairperson, "Prospects for Sexing Mammalian Sperm", Denver, CO, March 19-20, 1982.

87.   "Bioassay of Oil Shale Process Waters in Paramecium: Symposium on The Application of Short-Term Bioassays in the Analysis of Complex Environmental Mixtures.  Chapel Hill, North Carolina, January 25-27, 1982.

88.   "Novobiocin Modulation of Repair and Longevity", The Gerontological Society of American and Canadian Association on Gerontology.  Toronto, Canada, November 8-12, 1981, p. 91.

89.   "Genetics and Aging in Protozoa", Institute for Medical Research.  Camden, NJ. October 8, 1981.

90.   "Environmental Modulation of Longevity", Molecular Ciliate Conference.  Pingree Park, CO., August 17-20, 1981.

91.   "Genetics of Aging Protozoa", Workshop. XII International Congress of Gerontology.  Hamburg, Germany, July 12-17, 1981, p. 127.

92.   "Altered DNA Superhelicity and Novobiocin Sensitivity with Age", XII International Congress of Gerontology.  Hamburg, Germany (P.D. Lipitz, R.E. Stephens and J. Smith-Sonneborn, July 12-17, 1981.

93.   "Effect of Weak Pulsating Current on Longevity in Paramecium", 6th Intern. Symp. on Bioelectrochemistry and Bioenergetics, Tel Aviv, Israel, June 28-July 3, 1981.

94.   "Effect of Weak Pulsating Current on Longevity in Paramecium", 3rd EBI In Vitro Conference.  Hasbrouck Heights, NJ, June 4-5, 1981.

95.   "DNA Superhelicity and Aging", FIBER Science Advisory Board.  Washington, DC. June 3, 1981.

96.   "Paramecia as a Bioassay", Ohio State University.  Columbus, OH, October, 1980.

97.   "Paramecia as a Bioassay", Colorado State University, Ft. Collins, CO, November, 1980.

98.   "Environmental Modulation of Mutagenicity and Longevity", UCLA Medical Center.  Los Angeles, CA, November, 1980.

99.   "Environmental Modulation of Longevity and Mutagenesis", Indiana University,  Bloomington, IN, October, 1980.

100.  "Superhelicity and Aging", 33rd  Annual Meeting of Gerontological Society.  San Diego, CA, November, 1980.

101.  "Drug Induced Changes in Superhelicity of Paramecium DNA and its Biological Effects", Gordon Conference.  New Hampshire, CT, August, 1980.

102.  "Genetic Implication of Cloning", Western Regional Cooperative Conference.  Laramie, WY, June, 1980.

103.  "Biomarkers in Aging", FIBER Workshop Conference.  Washington, DC., May, 1980.

104.  "Modulation of Senescence", Sigma Xi, University of Wyoming, Laramie, WY, May, 1980.

105.  "Environmental Modulation of Senescence Repair and Mutagenesis", Battelle, Columbus Laboratories.  Columbus, OH, May, 1980.

106.  "Induced Current Effects on Senescence in Paramecium", Electrobiology 2nd In Vitro Workshop for Bioelectrochemistry Seminar.  St. Louis, MO, May, 1980.

107.  "Genetics of Ciliate Aging", Department of Molecular, Cellular and Developmental Biology.  University of Colorado.  Boulder, CO. April, 1980.

108.  "Aging and Its Regulation", Family Practice Center.  Casper, WY. April, 1980.

109.  "DNA Damage, Aging and Carcinogenesis", New York Hospital, Cornell Medical Center Division of Geriatrics and Gerontology.  New York, NY, November, 1979.

110.  "DNA Repair and Aging", 32nd  Annual Gerontological Society Symposium.  Washington, DC, November, 1979.

111.  "Use of a Ciliated Protozoan as  a Model System to Detect Toxic and Carcinogenic Agents", NATO Advanced Research Institute.  Monaco, Monte Carlo, September, 1979.

112.  "DNA Damage, Carcinogenesis and Aging", Biochemistry Department, George Washington School of Medicine.  Washington;, DC, May 1979.

113.  "What Determines Lifespan?", Japanese Medical Association.  Hakone, Japan, August, 1978.

114.  "Genetic Aspects of Cloning", Public Library Presentation, Laramie, WY, 1978.

115.  "Biological Effects of Carcinogens, Co-Mutagens and Repair on Survival and Longevity", Radiology Department, Ohio State University, Columbus, OH, May 1978.

116.  "Changes in Endocytic Capacity with Age", Ciliate Conference. Madison, WI, 1976.

117.  "Diploid Fibroblast Model Systems", NIH Workshop.  LaJolla, CA, 1975.

118.  "Changes in DNA Template Activity with Age", Regional American Society of Microbiology.  Pingree Park, CO, 1975.

119.  "Calendar Life Span versus Fission Age", Regional Society of American Microbiology.  Cheyenne, WY, 1975.

120.  "Changes in DNA Synthesis with Age", Regional Society of American Microbiology.  Cheyenne, WY, 1975.

121.  "Senescence in Paramecium aurelia", Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, 1974.

122.  "Parental Age and Progeny Viability", Regional Society of American Microbiology Association.  Laramie, WY, 1973.

123.  "Invertebrate Model Systems of Aging", Regional Society of American Microbiology Association.  Laramie, WY, 1973.

124.  "Diploid Fibroblast Techniques", NIH Workshop.  Lake Placid, NY, 1970.

125.  "Invertebrate Model Systems of Cellular Aging", Co-Chairman, NIH Workshop.  Memphis, TN, 1970.

126.  "Age Correlated Sensitivity to Ultraviolet Radiation in Paramecium:, Tenth Annual Meeting, American Society of Cell Biology.  San Diego, CA, 1970.

127.  "Pellicular DNA and Kinetosomes", Ciliate Conference.  Shelter Island, NY, 1966.

128.  "Chemical Identification of Kappa:, Federation Meetings.  Atlantic City, NY.  1962.

RESEARCH ACTIVITY AND SUPPORT
1967-69 National Science Foundation. Behavior and Nucleic Acids of Kinetosomes in Paramecium - $60,700.

1969-71 National Science Foundation.  Pellicular DNA and the Mechanism of Aging in Paramecium - $55,600.

1971-72 Arts and Sciences Division of Basic Research - $2,000.

1971-72 Graduate School Research Council - $2,000.

1972-73 University of Wyoming Summer Research Fellowship - $1,200.

1972-73 Arts and Sciences Division of Basic Research - $1,050.

1972-73 Graduate Research Coordination - $900.00

1974-75 Arts and Sciences Division of Basic Research - $1,000.

1974-75 Graduate Research Council - $1,000 

1974-75 National Science Foundation.  Aging Studies in Paramecium -$30,000.

1975-76 National Science Foundation.  Biochemistry of Cell  Rejuvenation - $18,000.

1976-77 Arts and Sciences Division of Basic Research - $700.00

1977-79ERDA.  Prescreen for Hazardous Chemicals - $83,535.

1977-79 National Science Foundation.  Nucleocytoplasmic Interaction and Age-Induced Mutations - $50,000.

1979-80DOE. Prescreen for Hazardous Chemicals - $62,290.

1979-80 Glenn Foundation.  Modulation of Life Span - $17,400.

1979-80 Electrobiology Company.  Induced Current Effects on Cellular    Aging - $9,500.

1979-80 Funds for Integrative Research.  Superhelicity Change with Cellular Aging, Travel Funds to Ohio State University -  $5,000.

1980-81 DOE.  Prescreen for Hazardous Chemicals - $65,000.

1981-82 DOE.  Prescreen for Hazardous Chemicals - $68,000.

1981-82 EBI.  Modulation of Longevity by Programmed Changes of Weak Pulsating Current - $15,000.

1982-83 General Molecular Applications.  Prescreen for Longevity Modulating Pharmaceutical - $110,000.

1984-85 NIPERA - Genotoxicity of Nickel Particulates - $10,000.

1985-86 Glenn Foundation, Private Foundation - $25,000.

1985-86 Don Yarborough, Private Benefactor - $50,000.

1985University of Wyoming Equipment Competition - $34,846.

1985-86 University of Wyoming Matching Equipment Funds, A & S, V.P. for Research, Zoology, VP. for Academic Affairs -  $35,000. 

1985-86 National Institute on Aging Conference Grant for Gerontological Society of America, Biology - $8,000.

1985-86 Wyoming Commission on Aging.  Support for Gerontology Minor $5,000.

1986-87 National Institute on Aging, Conference Grant for Biology of   Aging Conference - $25,000.

1986-87 A & S College for Program of Aging and Human Development - $12,000. Life Span Extension Foundation - $42,000.

1986-87 University of Wyoming, Match for Life Span Extension Grant -  $42,000.

1986-87 Glenn Foundation - $10,000.

1987-88 Glenn Foundation - $5,000.

1987-88 Vigor - $3,000.

1987-88 Virginia Medical College - $15,000.

1987-89 Glenn Foundation $20,000

1989-90 Sabbatical Leave

1990-93 University of Wyoming - $90,000.  Technology transfer and Bioengineering research in A&S.

1994-95 Max Baer Heart Fund Research Grant, Wyoming Fraternal Order of Eagles - $5000

1994-1995 Alzheimers Research, Wyoming Fraternal Order of Eagles, $2800.

1998-99 Ubiquitin expression during cardiac stress $5,000. Fraternal Order of Eagles.

1998-2001 Muscle Physiology and Protein Use by Overwintering Black Bears.

 NSF grant for $300,000 for 3 years.

Co-Principal Investigators:

Henry Harlow, Paul Iaizzo, Joan Smith Sonneborn, Thomas Beck  

(2001-2003) Ubiquitin Assays: Opioid Modulation of Stress Response  $3000 University of Wyoming

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