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Dr. Mark Gomelsky

Agriculture Bldg, Room 6007

Department of Molecular Biology

University of Wyoming

Department 33944

1000 E. University Ave.

Laramie, WY 82071

Phone: (307) 766-3522

Email: gomelsky@uwyo.edu

Dr. Mark Golmesky

Department of Molecular Biology

 

Publications (since 2009)

 

Hirsch index, h = 44; total citations >8,000 (Google Scholar)

Han S, Shen D, Wang YC, Chou SH, Gomelsky M, Gao YG, Qian G. 2019. A YajQ-LysR-like, c-di-GMP-dependent system regulating biosynthesis of an antifungal antibiotic in a crop-protecting bacterium, Lysobacter enzymogenes. Mol Plant Pathol in press.
Pallegar P, Pena-Castillo L, Langille E, Gomelsky M, Lang A. 2019. Cyclic-di-GMP-mediated regulation of gene transfer and motility in Rhodobacter capsulatus. J Bacteriol 10.1128/JB.00554-19.
Mushnikov NV, Fomicheva A, Gomelsky M, Bowman G. 2019. Inducible asymmetric cell division and cell differentiation in a bacterium. Nat Chem Biol 15:925-931.
Fomicheva A, Zhou C, Sun QQ, Gomelsky M. 2019. Engineering adenylate cyclase activated by near-infrared window light for mammalian optogenetic applications. ACS Synth Biol  8:1314-1324.
Xu G, Han S, Huo, C, Chin KH, Chou SH, Gomelsky M, Qian G, Liu F. 2018. Signaling specificity in the c-di-GMP-dependent network regulating antibiotic synthesis in Lysobacter. Nucl Acids Res gky803.
Zhang J, Chen T, Yang Y., Du J, Li H, Troxell B, He M, Carrasco S, Gomelsky M, Yang XF. 2018. Positive and negative regulation of glycerol utilization by the c-di-GMP binding protein PlzA in Borrelia burgdorferi. J Bacteriol pii: JB.00243-18.
Bjarnsholt T, Buhlin K, Dufrêne YF, Gomelsky M, Moroni A, Ramstedt M, Rumbaugh KP, Schulte T, Sun L, Åkerlund B, Römling U. 2018. Biofilm formation – What we can learn from recent developments. J Intern Med 284:332-345.
Latanova AA, Petkov S, Kilpelainen A, Jansons J, Latyshev O, Kuzmenko Y, Hinkula J, Abakumov M, Valuev-Elliston V, Gomelsky M, Karpov V, Chiodi F, Wahren B, Logunov D, Starodubova E, Isaguliants M. 2018. Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity. Sci Rep 8:8078.
Elbakush AM, Miller KW, Gomelsky M. 2018. CodY-mediated c-di-GMP-dependent inhibition of mammalian cell invasion in Listeria monocytogenes. J Bacteriol 200:e00457-17.
Gomelsky M. 2017. Photoactivated cells link diagnosis and therapy. Sci Transl Med 9:eaan3936.
Ryu MH, Fomicheva F, O’Neal L, Alexandre G, Gomelsky M. 2017. Using light-activated enzymes for modulating intracellular c‑di-GMP levels in bacteria. Methods Mol Biol 1657:169-186.
O’Neal L, Ryu MH, Gomelsky M, Alexandre G. 2017. Optogenetic manipulation of c-di-GMP levels reveals the role of c-di-GMP in regulating aerotaxis receptor activity in Azospirillum brasilense. J Bacteriol 199:e00020-17.
Ryu MH, Fomicheva F, Moskvin OV, Gomelsky M. 2017. Optogenetic module for dichromatic control of c-di-GMP signaling. J Bacteriol 199:e00014-17.
Chen Y, Xia J, Su Z, Xu G, Gomelsky M, Qian G, Liu F. 2017. The regulator of type IV pili synthesis, PilR, from Lysobacter controls antifungal antibiotic production via a c-di-GMP pathway. Appl Environ Microbiol pii: AEM.03397-16.
Hengge R, Galperin MY, Ghigo JM, Gomelsky M, Green J, Hughes KT, Jenal U, Landini P. 2016. Systematic nomenclature for GGDEF and EAL domain-containing c-di-GMP turnover proteins of Escherichia coli. J Bacteriol 198:7-11.
Köseoğlu VK, Heiss C, Azadi P, Topchiy E, Güvener ZT, Lehmann TE, Miller KW, Gomelsky M. 2015. Listeria monocytogenes exopolysaccharide: origin, composition, biosynthetic machinery, and c-di-GMP-dependent regulation. Mol Microbiol 96:728-43.
Ryu MH, Youn H, Kang IH, Gomelsky M. 2015. Identification of bacterial guanylate cyclases. Proteins 83:799-804.
McCarter LL, Gomelsky M. 2015. Fifty ways to inhibit motility via c-di-GMP: the emerging P. aeruginosa swarming story. J Bacteriol 197:406-9.
Chen LH, Köseoğlu VK, Güvener ZT, Myers-Morales T, Reed JM, D’Orazio SEF, Miller KW, Gomelsky M. 2014. Cyclic di-GMP-dependent signaling pathways in the pathogenic firmicute Listeria monocytogenes. PLoS Pathog 10:e1004301.
Ryu MH, Kang IH, Nelson MD, Jensen TM, Lyuksyutova AI, Siltberg-Liberles J, Raizen DM, Gomelsky M. 2014. Engineering adenylate cyclases regulated by near-infrared window light. Proc Natl Acad Sci USA 111:10167-72.
Fang X, Ahmad I, Blanka A, Schottkowski M, Cimdins A, Galperin MY, Römling U, Gomelsky M. 2014. GIL, a new c-di-GMP binding protein domain involved in cellulose synthesis regulation in enterobacteria. Mol Microbiol 93:439–452.
Ye M, Zhang J, Fang X, Lawlis GB, Troxell B, Zhou Y, Lou Y, Gomelsky M, Lou Y, Yang XF. 2014. DhhP, a c-di-AMP phosphodiesterase of Borrelia burgdorferi, is essential for cell growth and virulence. Infect Immun 82:1840-9.
Ryu MH, Hull NC, Gomelsky M. 2014. Metabolic engineering of Rhodobacter sphaeroides for improved hydrogen production. Intl J Hydrogen Energy 39:6384-6390.
Ryu MH, Gomelsky M. 2014. Synthetic second messenger module controlled by near-infrared window light. ACS Synth Biol 3:802-810.
Gomelsky M. 2014. Special issue on synthetic photobiology. (Editorial) ACS Synth Biol 3:780-781.
Farmer RM, Laguna R, Panescu J, McCoy A, Logsdon B, Zianni M, Moskvin OV, Gomelsky M, Tabita FR. 2014. Altered residues in key proteins influence the expression and activity of the nitrogenase complex in an adaptive CO2 fixation deficient mutant strain of Rhodobacter sphaeroides. Microbiol 160:198-208.
Gomelsky M, Galperin MY. 2013. Bacterial second messengers, cGMP and c-di-GMP, in a quest for regulatory dominance. EMBO J 32:2421-3.
Gomelsky M. 2013. A zinc lock on GGDEF domain dimerization inhibits E. coli biofilms. Structure 21:1067-8.
Hu J, Wang B, Fang X, Means WJ, McCormick RJ, Du M, Gomelsky M, Zhu MJ. 2013. c-di-GMP signaling regulates E. coli O157:H7 adhesion to colonic epithelium. Vet Microbiol 164:344-51.
Russell MH, Bible AN, Fang X, Gooding J, Campagna S, Gomelsky M, Alexandre G. 2013. Integration of the second messenger c-di-GMP into the chemotactic signaling pathway promotes sensory adaptation. mBio 4:e00001-13.
Gomelsky M, Zeilstra-Ryalls JH. 2013. The living genome of a purple nonsulfur photosynthetic bacterium: Overview of the Rhodobacter sphaeroides transcriptome landscapes. Adv Botanical Res 66:179-203.
Römling U, Galperin MY, Gomelsky M. 2013. Cyclic di-GMP: The first 25 years of a universal bacterial second messenger. Microbiol Mol Biol Rev 77:1-52.
Branchu P, Hindré T, Fang X, Thomas R, Gomelsky M, Claret L, Hareld J, Gobert AP, Martin C. 2013. The c-di-GMP phosphodiesterase VmpA absent in Escherichia coli K12 strains affects motility and biofilm formation in the enterohemorrhagic O157:H7 serotype. Vet Immunol Immunopathol 152:132-140.
Hull TD, Ryu MH, Sullivan MJ, Klena NT, Johnson RC, Geiger RM, Gomelsky M, Bennett JA.  2012. C-di-GMP phosphodiesterases RmdA and RmdB are involved in regulating colony morphology and development in Streptomyces coelicolor. J Bacteriol 194:4642-4651.
Gomelsky M. 2012. C-di-GMP-mediated decisions in the surface-grown Vibrio parahaemolyticus: A different kind of motile-to-sessile transition. J Bacteriol 194:911-913.
Hobley L, Fung RK, Lambert C, Harris MA, Dabhi JM, King SS, Lambert C, Uchida K, Basford S, Ahmad R, Aizawa SI, Gomelsky M, Sockett RE.  2012. Discrete cyclic di-GMP-dependent control of bacterial predation versus axenic growth in Bdellovibrio bacteriovorus. PLoS Pathog 8:e1002493.
Monteiro C, Fang X, Ahmad I, Gomelsky M, Römling U. 2011. Regulation of biofilm components in Salmonella enterica serovar Typhimurium by lytic transglycosylases involved in cell wall turnover. J Bacteriol 193:6443-6451.
Tsuzuki M, Moskvin OV, Kuribayashi M, Sato K, Retamal S, Abo M, Zeilstra-Ryalls J, Gomelsky M. 2011. Salt-stress induced changes in the transcriptome, compatible solutes and membrane lipids in the facultatively phototrophic bacterium Rhodobacter sphaeroides. Appl Environ Microbiol 77:7551-7559.
Gomelsky M, Hoff WH. 2011. Light helps bacteria make important lifestyle decisions. Trends Microbiol 19:441-448.
He M, Ouyang Z, Troxell B, Xu H, Moh A, Piesman J, Norgard MV, Gomelsky M, Yang XF. 2011. Cyclic di-GMP is essential for the survival of the Lyme disease spirochete in ticks. PLoS Pathog 7:e1002133.
Smith A, Balazinska M, Baru C, Gomelsky M, McLennan M, Rose L, Smith B, Stewart, E, Kolker E. 2011. Biology and data-intensive science in the beginning of the 21st century. OMICS 15:209-212.
Gomelsky M. 2011. cAMP, c-di-GMP, c-di-AMP and now cGMP: Bacteria use them all! Mol Microbiol 79:562-565.
Bobrov AG, Kirillina O, Ryjenkov DA, Waters CM, Price PA, Fetherson JD, Mack D, Goldman WE, Gomelsky M, Perry RD. 2011. Systematic analysis of cyclic di-GMP signaling  enzymes  and  their  role  in  biofilm  formation  and  virulence  in  Yersinia  pestis. Mol Microbiol 79:533–551. (Faculty of 1000 Medicine: “Recommended“)
Moskvin OV, Bolotin D, Wang A, Ivanov PS, Gomelsky M. 2011. Rhodobase, a meta-analytical tool for reconstructing gene regulatory networks in a model photosynthetic bacterium. BioSystems 103:125-131
Ryu MH, Moskvin OV, Siltberg-Liberles J, Gomelsky M. 2010. Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications. J Biol Chem 285: 41501-41508. (Faculty of 1000 Biology: “Recommended“)
Golomysova AN, Gomelsky M, Ivanov PS. 2010. Flux balance analysis of the photoheterotrophic growth of Rhodobacter sphaeroides relevant to biohydrogen production. Intl J Hydrogen Energy  35:12751-12760.
Moskvin OV, Gilles-Gonzalez MA, Gomelsky M. 2010. The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domains. J Bacteriol 192:5253-5256.
Fang X, Gomelsky M. 2010. A post-translational, c-di-GMP-dependent mechanism regulating bacterial flagellar motility. Mol Microbiol  76:1295-1305.  (Faculty of 1000 Biology: “Recommended“)
Golomysova AN, Gomelsky M, Ivanov PS. 2010. Mathematical modeling of bacterial metabolism. Moscow University Physics Bulletin 65:230-233.
Gomelsky M. 2009. The core pathway: diguanylate cyclases, phosphodiesterases, and c-di-GMP-binding proteins. Chapter 4, pp. 37-56. In The second messenger cyclic di-GMP. (A. Wolfe and K. Visick, eds.) ASM Press, Washington, DC.
Gomelsky M. 2009. C-di-GMP-binding CRP-like protein: a spectacular new role for a veteran signal transduction actor. J Bacteriol 191:6785-6787.
Barends TRM, Hartmann E, Griese J, Beitlich T, Kirienko NV, Ryjenkov DA, Reinstein J, Shoeman RL, Gomelsky M#, Schlichting I#. 2009. Structure and mechanism of a bacterial   light-regulated cyclic nucleotide phosphodiesterase. Nature 459:1015-1018 (#, corresponding authors). (Faculty of 1000 Biology: “Must read”)
PATENTS AND PATENT APPLICATIONS

Mark Gomelsky Google Patents Page

Bowman G, Mushnikov N, Gomelsky M. Microbial stem cell technology. US Patent Application (Priority date 2018-04-05).
Bushman J, Gomelsky M. Near-infrared window light-mediated control of implanted cells for immunosuppression and regenerative medicine. US Patent Application US20190070315A1. (Priority date 2017-09-01)
Gomelsky M, Miller KW, Köseoğlu VK. 2019. Compositions and methods for making and using hydrolytic enzymes for degrading polysaccharides made by foodborne pathogenic bacteria. US Patent 10,383,338. WO 2016/069888  (priority date 2014-10-29).
Gomelsky M, Ryu MH. 2014. Near-infrared light-activated proteins. US Patents 8,835,399 (2014) and 10,041,057 (2018). European Patent EP 2,737,062. (Priority date 2011-07-27)

 

Contact Us

Dr. Mark Gomelsky

Agriculture Bldg, Room 6007

Department of Molecular Biology

University of Wyoming

Department 33944

1000 E. University Ave.

Laramie, WY 82071

Phone: (307) 766-3522

Email: gomelsky@uwyo.edu

1000 E. University Ave. Laramie, WY 82071
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