Baskaran Thyagarajan, M.Pharm., Ph.D.
Assistant Professor of Pharmaceutics
email@example.com • (307) 766-6482 • HS 279
Baskaran Thyagarajan, M. Pharm., Ph.D., joined the UW School of Pharmacy faculty at the beginning of the fall 2011 semester as an Assistant Professor of Pharmaceutics. He was previously a Research Assistant Professor with the Division of Nephrology at the University of Rochester Medical Center Department of Medicine in Rochester, New York. Dr. Thyagarajan led the New Drug Discovery Research - Safety Pharmacology group in Ranbaxy Research Labs (Multinational Pharma Giant of India).
Dr. Thyagarajan received a Bachelor of Pharmacy (1994) from Madras Medical College in Chennai, India, a Master of Pharmacy (1996) from Banaras Hindu University Institute of Technology in Varanasi, India and a Ph.D. (2001) in pharmacy from Karl-Franzens University of Graz in Austria.
Dr. Thyagarajan has numerous publications, abstracts, and presentations and has received several awards for his research.
Molecular mechanisms of neuronal exocytosis and endocytosis
Role of TRP channels and lipid microdomains in synaptic transmission
Botulinum neurotoxin antidotes
Magnetic nanospheres as targeted drug delivery carriers
Pharmaceutical Dosage Forms, Biopharmaceutics and Pharmacokinetics
Selected Peer Reviewed Publications:
Allman E, B Thyagarajan B and KW Nehrke. The Inositol 1,4,5-Trisphosphate Receptor in C. elegans. WIREs Membrane Transport and Signaling. 2011
Ho, M, LH Chang, M Pires-Alves, B Thyagarajan, JE Bloom, Z Gu, KK Aberle, SA Teymorian, Y Bannai, JJ McArdle and BA Wilson. Recombinant Botulinum Neurotoxin A Heavy Chain-based Delivery Vehicles for Neuronal Cell Targeting. Protein Engineering Design & Selection (PEDS) Nov. 04. 1-7, 2010
Potian JG, Vishwendra Patel, JJ McArdle and B Thyagarajan. The inveterate botulinum neurotoxin A ushers in exoendocytic crypts. The Botulinum Journal 2010. 1(4). 418-430.
Thyagarajan, B, JG Potian, CC Garcia, K Högnason, K Čapková, ST Moe, AR Jacobson, KD Janda & JJ McArdle. Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions. Neuropharmacology. 2010. March 10
Thyagarajan, B, N Krivitskaya, K Högnason, JG Potian, CC Garcia and JJ McArdle. Capsaicin protects functions of mouse neuromuscular junctions from the paralytic effects of botulinum neurotoxin A. J. Pharmacol. Exp. Ther. 2009; Nov; 331(2):361-71
Thyagarajan, B, V Lukacs and T Rohacs. Hydrolysis of phosphatidylinositol 4,5- bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J. Biol Chem. 2008 May 30;283(22):14980-7
Lukacs, V, Thyagarajan, B, A Balla,T Balla and T Rohacs. TRPV1 - Regulation by phosphoinositides. The Journal of Neuroscience, June 27, 2007 26 (26): 7070-7080 (First two authors contributed equally)
Varnai, P, B Thyagarajan ,T Rohacs and T Balla. Rapidly inducible changes in phosphatidyl inositol 4,5-bisphosphate levels to study multiple regulatory functions of the lipid in intact living cells. J Cell Biol. 2006 Nov 6;175(3):377-82
Thyagarajan, B, M Poteser, C Romanin, H Kahr, MX Zhu and K Groschner. Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling. J. Biol. Chem. 2001. Dec. 21, 276 (51). 48149-48158
Lintschinger, B, MB Geldsetzer, T Baskaran, WF Graier, C Romanin, MX Zhu and K Groschner. Coassembly of Trp 1 and Trp 3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels. J. Biol. Chem. 2000 Sep 8; 275 (36). 27799-27805
Dhanaraju, MD, KS Kumaran, T Baskaran and MS Moorthy. Enhancement of bioavailability of griseofulvin by its complexation with beta-Cyclodextrin. Drug Dev. Ind. Pharm. 1998. 24(6). 583-587
Professional member of American Physiological Society
Member of Society for Neuroscience
Member of Biophysical Society
Member of Society of General Physiologist
Life member of Association of Pharmaceutical Teachers of India