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School of Pharmacy

College of Health Sciences

Baskaran Thyagarajan, M.Pharm., Ph.D.

Assistant Professor of Pharmaceutics

bthyagar@uwyo.edu • (307) 766-6482 • HS 279

Baskaran Thyagarajan, M. Pharm., Ph.D., joined the UW School of Pharmacy faculty at the beginning of the fall 2011 semester as an Assistant Professor of Pharmaceutics. He was previously a Research Assistant Professor with the Division of Nephrology at the University of Rochester Medical Center Department of Medicine in Rochester, New York. Dr. Thyagarajan led the New Drug Discovery Research - Safety Pharmacology group in Ranbaxy Research Labs (Multinational Pharma Giant of India).

Dr. Thyagarajan received a Bachelor of Pharmacy (1994) from Madras Medical College in Chennai, India, a Master of Pharmacy (1996) from Banaras Hindu University Institute of Technology in Varanasi, India and a Ph.D. (2001) in pharmacy from Karl-Franzens University of Graz in Austria.

Dr. Thyagarajan has numerous publications, abstracts, and presentations and has received several awards for his research.

Curriculum Vitae

Research Interests:

Molecular mechanisms of neuronal exocytosis and endocytosis

Role of TRP channels and lipid microdomains in synaptic transmission

Neurodegenerative diseases

Muscular dystrophy

Botulinum neurotoxin antidotes

Magnetic nanospheres as targeted drug delivery carriers

Teaching:

Pharmaceutical Dosage Forms, Biopharmaceutics and Pharmacokinetics

Publications and Patents

Full Length Research Articles

1. Baskaran, P and B Thyagarajan. Measurement of Basal and Forskolin-Stimulated Lipolysis in Inguinal Adipose Fat Pads. Jove April 2017 (In Press).

2. Thyagarajan, B, JG Potian, JJ McArdle and P Baskaran. Perturbation to Cholesterol at the Neuromuscular Junction Confers Botulinum Neurotoxin A Sensitivity to Neonatal Mice. Toxicol. Sci. June 22, 2017

3. Baskaran, M, P Baskaran, A Navamoney and B Thyagarajan. Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles. Pharm Res. March 07 2017

4. Baskaran, P, V Krishnan, K Fettel, G Pang, Z Zhu, J Ren and B Thyagarajan. TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue. Int. J. Obes. Feb. 2017 p 1-11.

5. Baskaran, P, V Krishnan, J Ren and B Thyagarajan. Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. Brit. J.Pharmacol. May 2016 DOI: 10.1111/bph.13514

6. Asuthkar S, Elustondo PA, Demirkhanyan L, SunX, Baskaran P, Velpula KK, Thyagarajan B, Pavlov E, ZakharianE. The TRPM8 Protein is a Testosterone Receptor. Part I: Biochemical Evidence for Direct TRPM8-Testosterone Interactions. J Biol Chem. 2014 Dec 5. pii: jbc.M114.610824.

7. Asuthkar S, Demirkhanyan L, Sun X, Elustondo P, KrishnanV, Baskaran P, Velpula KK, Thyagarajan B, Pavlov E, ZakharianE. The TRPM8 Protein is a Testosterone Receptor. Part II: Functional Evidence for an Ionotropic Effect of Testosterone on TRPM8. J Biol Chem. 2014 Dec 5. pii: jbc.M114.610873.

8. Thyagarajan, B, JG Potian, P Baskaran andJJ McArdle. Capsaicin modulates acetylcholine release at myoneuroal junction. Eur. J. Pharmacol. 2014Dec 5;744:211-9. doi: 10.1016/j.ejphar.2014.09.044. Epub 2014 Oct 23.

9. Baskaran, P and B Thyagarajan. Acute and chronic effects of botulinum neurotoxin A in mammalian neuromuscular junction. Muscle and Nerve. 2013 Nov 12. PMID: 24162247

10. Baskaran, P, TE Lehmann, E Topchiy, NThirunavukkarasu, S Deshpande, BR Singh and B Thyagarajan. Effects of EnzymaticallyInactive Recombinant Botulinum Neurotoxin Type A at the Mouse Neuromuscular Junctions. Toxicon 2013 Jun 25. pii: S0041-0101(13) 00228-6. PMID:23810945

11.Garcia CC, JG Potian, K Högnason, B Thyagarajan, L. G. Sultatos, VH Routh, and JJ McArdle. Acetylcholinesterase downregulation contributes to neuromuscular junction dysfunction in experimental type I diabetic neuropathy. Am. J. Physiol. 2012. PMID: 22739110. PMID: 21051321

12. Ho, M, LHChang, M Pires-Alves, B Thyagarajan, JE Bloom, Z Gu, KK Aberle, SATeymorian, Y Bannai, JJ McArdle and BA Wilson. RecombinantBotulinum Neurotoxin A Heavy Chain-based Delivery Vehicles for Neuronal CellTargeting. Protein Eng Des Sel. 2011 Mar;24(3):247-53. PMID:21051321

13. Potian JG, Vishwendra Patel, JJ McArdle and B Thyagarajan. The inveterate botulinum neurotoxin A ushers in exoendocytic crypts. The Botulinum J. 2010. 1(4). 418-430.

14. Potian, JG, B Thyagarajan, K Hognason, F Lebeda, JJ Schmidt and JJ McArdle. Investigation of “CRATKML” derived peptides against botulinum neurotoxin A poisoning in vivo and in vitro. The Botulinum J. 2010. 1(4). 407-41

15. Thyagarajan, B, JG Potian, CC Garcia, KHögnason, K Čapková, ST Moe, AR Jacobson, KD Janda& JJ McArdle. Effects ofhydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisonedmouse neuromuscular junctions. Neuropharmacology. 2010. March 10. PMID:20211192

16. Thyagarajan, B, N Krivitskaya, K Högnason, JGPotian, CC Garcia and JJ McArdle. Capsaicin protects functions of mouseneuromuscular junctions from the paralytic effects of botulinum neurotoxin A.J. Pharmacol. Exp. Ther. 2009; Nov; 331(2):361-71. PMID: 19654265.

17. Patel, RJ, PD Patel, MM Patel, NJ Patel and B Thyagarajan. Mechanisms of potentiation of Angiotensin II-induced contractile response of isolated rat aorta by hydrogen peroxide and tert-butyryl hydroperoxide. Ind. J. Pharmacol. 2009; 41(3): 140-143. PMID: 20442823

18. Zakharian, E, B Thyagarajan, RJ French, E Pavlov and T Rohacs. Inorganic polyphosphate modulates TRPM8 channels. PLoS ONE. 2009;4(4):e5404

19. Thyagarajan, B, B Benn, S Christakos and T Rohacs. Phospholipase C mediated regulation of TRPV6 channels: implications in active intestinal Ca2+ transport. Mol Pharmacol. 2009. 75(3):608-16. PMID: 18528787.

20. Thyagarajan, B, V Lukacs and T Rohacs.Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J. Biol Chem. 2008. 283(22):14980-7

21. Lukacs, V, Thyagarajan, B, A Balla, T Balla and T Rohacs. TRPV1 – Regulation b phosphoinositides. The Journal of Neuroscience, June 27, 2007 26 (26): 7070-7080 (First two authors contributed equally). PMID: 17596456

22. Varnai, P, B Thyagarajan, T Rohacs and T Balla. Rapidly inducible changes in phosphatidyl inositol 4,5-bisphosphate levels to study multiple regulatory functions of the lipid in intact living cells. J Cell Biol. 2006 Nov 6;175(3):377-82. PMID: 17088424.

23. Baskaran, T, R Malli, K Schmidt, WF Graier and K Groschner. Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling. Br. J. Pharmacol. 2002.137(6):821-30. PMID:12411413

24. Thyagarajan, B, M Poteser, C Romanin, H Kahr, MX Zhu and K Groschner. Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling. J. Biol. Chem. 2001. 276 (51). 48149-48158. PMID: 11600493

25. Lintshinger, B, MB Geldsetzer, T Baskaran, WF Graier, C Romanin, MX Zhu and K Groschner. Coassembly of Trp 1 and Trp 3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels. J. Biol. Chem. 2000 Sep 8; 275 (36). 27799-27805. PMID 18002720

26. Dhanaraju, MD, KS Kumaran, T Baskaran and MS Moorthy. Enhancement of bioavailability of griseofulvin by its complexation with beta-Cyclodextrin. Drug Dev. Ind. Pharm. 1998. 24(6). 583-587

Peer-reviewed Review Articles

1. Thyagarajan, B. and Foster, MT. Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans. Horm Mol Biol Clin Investig 2017 April (Accepted).

2. Baskaran, P, VKrishnan and B Thyagarajan. Implications of Obesity on Neuromuscular Functions - The known and unknown. BAOJ Obe Weigt Manage 2015, 1:1 1:003

3. B Thyagarajan and SS Deshpande. Cotrimoxazole and Neonatal Kernicterus: A Review. Drug Chem Toxicol. 2013 Oct 7. PMID: 24099411

4. Allman E, B Thyagarajan B and KW Nehrke. The Inositol 1,4,5-Trisphosphate Receptor in C. elegans. WIREs Membrane Transport and Signaling. 2012

5. Rohacs, T, B Thyagarajan and V Lukacs. Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol. 2008 Apr-Jun;37(2-3):153-63. PMID: 19073818

6. Meru, AV, S Mittra, B Thyagarajan and A Chugh. Intermittent claudication: An overview. Atherosclerosis 2006 Aug;187(2):221-37. PMID:16386260

Peer-reviewed Research Articles on Social and Administrative Pharmacy

1. Singh, R, L Staubach, J Frantz and B Thyagarajan. Understanding Food Choice, Medication Use and Health From Lean and Non Lean Resident Perspectives in a Rural State. BAOJ Pharm. Sci. 2017, 3: 2 3: 034.

Patents

1. Thyagarajan, B and P Baskaran. United States Patent No. US9, 320, 749 B2. Nanoparticle delivery system for targeted anti-obesity treatment

2. Thyagarajan, B and P Baskaran. United States Patent 20160228548. Nanoparticle Delivery System for Targeted Anti-Obesity Treatment

3. Thyagarajan, B and JJ McArdle. United States Patent 20100303932. Methods for Attenuating the Effects of Botulinum Toxin

Professional Memberships

Professional member of American Physiological Society

Member of Society for Neuroscience

Member of Biophysical Society

Member of Society of General Physiologist

Life member of Association of Pharmaceutical Teachers of India


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