Baskaran Thyagarajan, M.Pharm., Ph.D.

Assistant Professor of Pharmaceutics

bthyagar@uwyo.edu • (307) 766-6482 • HS 279

Baskaran Thyagarajan, M. Pharm., Ph.D., joined the UW School of Pharmacy faculty at the beginning of the fall 2011 semester as an Assistant Professor of Pharmaceutics. He was previously a Research Assistant Professor with the Division of Nephrology at the University of Rochester Medical Center Department of Medicine in Rochester, New York. Dr. Thyagarajan led the New Drug Discovery Research - Safety Pharmacology group in Ranbaxy Research Labs (Multinational Pharma Giant of India).

Dr. Thyagarajan received a Bachelor of Pharmacy (1994) from Madras Medical College in Chennai, India, a Master of Pharmacy (1996) from Banaras Hindu University Institute of Technology in Varanasi, India and a Ph.D. (2001) in pharmacy from Karl-Franzens University of Graz in Austria.

Dr. Thyagarajan has numerous publications, abstracts, and presentations and has received several awards for his research.

Curriculum Vitae

Research Interests:

Molecular mechanisms of neuronal exocytosis and endocytosis

Role of TRP channels and lipid microdomains in synaptic transmission

Neurodegenerative diseases

Muscular dystrophy

Botulinum neurotoxin antidotes

Magnetic nanospheres as targeted drug delivery carriers

Teaching:

Pharmaceutical Dosage Forms, Biopharmaceutics and Pharmacokinetics

Selected Peer Reviewed Publications:

Allman E, B Thyagarajan B and KW Nehrke. The Inositol 1,4,5-Trisphosphate Receptor in C. elegans. WIREs Membrane Transport and Signaling. 2011

Ho, M, LH Chang, M Pires-Alves, B Thyagarajan, JE Bloom, Z Gu, KK Aberle, SA Teymorian, Y Bannai, JJ McArdle and BA Wilson. Recombinant Botulinum Neurotoxin A Heavy Chain-based Delivery Vehicles for Neuronal Cell Targeting. Protein Engineering Design & Selection (PEDS) Nov. 04. 1-7, 2010

Potian JG, Vishwendra Patel, JJ McArdle and B Thyagarajan. The inveterate botulinum neurotoxin A ushers in exoendocytic crypts. The Botulinum Journal 2010. 1(4). 418-430.

Thyagarajan, B, JG Potian, CC Garcia, K Högnason, K Čapková, ST Moe, AR Jacobson, KD Janda & JJ McArdle. Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions.  Neuropharmacology. 2010. March 10

Thyagarajan, B, N Krivitskaya, K Högnason, JG Potian, CC Garcia and JJ McArdle. Capsaicin protects functions of mouse neuromuscular junctions from the paralytic effects of botulinum neurotoxin A. J. Pharmacol. Exp. Ther. 2009; Nov; 331(2):361-71

Thyagarajan, B, V Lukacs and T Rohacs. Hydrolysis of phosphatidylinositol 4,5- bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J. Biol Chem. 2008 May 30;283(22):14980-7

Lukacs, V, Thyagarajan, B, A Balla,T  Balla and T Rohacs. TRPV1 - Regulation by phosphoinositides. The Journal of Neuroscience, June 27, 2007 26 (26): 7070-7080 (First two authors contributed equally)

Varnai, P, B Thyagarajan ,T  Rohacs and T Balla. Rapidly inducible changes in phosphatidyl inositol 4,5-bisphosphate levels to study multiple regulatory functions of the lipid in intact living cells. J Cell Biol. 2006 Nov 6;175(3):377-82

Thyagarajan, B, M Poteser, C Romanin, H Kahr, MX Zhu and K Groschner. Expression of Trp3 determines sensitivity of capacitative Ca²⁺ entry to nitric oxide and mitochondrial Ca²⁺ handling. J. Biol. Chem. 2001. Dec. 21, 276 (51). 48149-48158

Lintschinger, B, MB Geldsetzer, T Baskaran, WF Graier, C Romanin, MX Zhu and K Groschner. Coassembly of Trp 1 and Trp 3 proteins generates diacylglycerol- and Ca²⁺-sensitive cation channels. J. Biol. Chem. 2000 Sep 8; 275 (36). 27799-27805

Dhanaraju, MD, KS Kumaran, T Baskaran and MS Moorthy. Enhancement of bioavailability of griseofulvin by its complexation with beta-Cyclodextrin. Drug Dev. Ind. Pharm. 1998.  24(6). 583-587

Professional Memberships:

Professional member of American Physiological Society

Member of Society for Neuroscience

Member of Biophysical Society

Member of Society of General Physiologist

Life member of Association of Pharmaceutical Teachers of India