Kurt Dolence

Education 

1987, University of Kentucky, Lexington, KY, Ph.D. Pharmaceutical Sciences 

1983, University of Wyoming, Laramie, WY, B.S. Pharmacy 

Professional Experience

2005 - 2023, Associate Professor of Medicinal Chemistry, University of Wyoming

January 2004 - 2023, Adjunct faculty Dept. of Chemistry, University of Wyoming

1999-2005, Assistant Professor of Medicinal Chemistry, University of Wyoming 

1996-1999, Post-Doctoral Research Associate, University of Utah, Department of Chemistry

1994-1996, Manager, Bioconjugate Chemistry; Surface Engineering Technologies (Division of InnerDyne, Inc.

1992-1994, Senior Research Scientist, CardioPulmonics, Inc.

1990-1992, Research Chemist, CardioPulmonics, Inc.

1987-1990, Post-Doctoral Research Associate, University of Notre Dame, Department of Chemistry

Research Interests:

Organic and bioorganic chemistry

Teaching:

Medicinal Chemistry

Publications:

REFEREED CHAPTERS IN BOOKS

M.J. Miller, F. Malouin, E.K. Dolence, C.M. Gasparski, M. Ghosh, P.R. Guzzo, B.T. Lotz, J.A. McKee, A.A. Minnick, and M. Teng; "Iron Transport-Mediated Drug Delivery", in Recent Advances in the Chemistry of Anti-infective Agents, Bentley, P. H.; Ponsford, R., Eds.; Royal Society of Chemistry: Cambridge, 1993, pp. 135-159.

REFEREED JOURNAL ARTICLES

Yamreudeewong, Weeranuj; Dolence, E. Kurt; Pahl, Deborah "Stability of Donepezil in an Extemporaneously Prepared Oral Liquid" J. of Pharmacy Practice, 2006, in press

Yamreudeewong, Weeranuj; Dolence, E. Kurt; Pahl, Deborah "Stability of two extemporaneously prepared oral Metoprolol and Carvedilol Liquids" Hospital Pharmacy 2006, 41, 254-259.

Mary Beth Flanders Stepans, Susan L. Wilhelm and E. Kurt Dolence "Smoking Hygiene: Reducing Infant Exposure to Tobacco" Biological Research for Nursing 2006, 8, 104-114.

Richard T. Mayer, E. Kurt Dolence, Gabriele E. Mayer "A Real-Time Fluorescence Assay for Measuring N-Dealkylation" Drug Metabolism and Disposition Published on-line October 11, 2006 as doi:10.1124/dmd.106.011601, in press.

Christine M. Lewis, E. Kurt Dolence, Catherine S. Hubbard and James D. Rose "Identification of roughskin newt medullary vasotocin target neurons with a fluorescent vasotocin conjugate" J. of Comparative Neurology 2005, 491, 381-389.

E.K. Dolence, Gabriele Mayer and Brenda D. Kelly "Optically Active Diethyl Sulfamidate 2-Phosphonates as Chiral Synthons for the Synthesis of b-Substituted a-Amino Phosphonates," Tetrahedron: Asymmetry 2005, 16, 1583-1594. 

Li, S-Yan; Du, M.; Dolence, E.K.; Fang, X.; Mayer, G.; Ceylan-Isik, A.F.; LaCour, K.; Yang, X.; Wilbert, J.C.; Sreejayan, N.; Ren, J. "Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation end products and protein modification" Aging Cell 2005 4, 57-64. 

C.M. Lewis, E.K. Dolence, Z. Zhang, J.D. Rose "Fluorescent Vasotocin Conjugate for Identification of the Target Cells for Brain Actions of Vasotocin," Bioconjugate Chemistry 2004, 15, 909-914. 

E.K. Dolence and Jason Roylance "Optically Active Diethyl N-(p-Toluenesulfonyl)-Aziridine 2-Phosphonates as Chiral Synthons for the Synthesis of b-Substituted a-Amino Phosphonates," Tetrahedron: Asymmetry 2004, 15, 3307-3322. 

P.R. Wade, E. Jacobson, K. Garcia, J. Lieb, E.K. Dolence, O.B. Balemba "Enterochromaffin cells and serotonergic neurons in the guinea pig distal colon are spared during aging," Neurogastr. Motility 2003, 15 (2), page 201. 

Flynn, F.W., Heyborne, R. & Dolence, K. (2001) Internalization of NK3 receptor agonist, senktide, following intraventricular injection in rat. Regulatory Peptides, 97, 47. 

E.K. Dolence, J.M. Dolence, C.D. Poulter "Solid-Phase Synthesis of a Radiolabeled, Biotinylated, and Farnesylated Ca¬1a2X Peptide Substrate for Ras- and a-Mating Factor Converting Enzyme," Bioconjugate Chemistry 2001, 12, 35-43.

J.M. Dolence, L.E. Steward, E.K. Dolence, D.H. Wong, C.D. Poulter "Studies with Recombinant Saccharomyces cerevisiae CaaX Prenyl Protease Rce1p," Biochemistry 2000, 39, 4096-4104.

E.K. Dolence, J.M. Dolence, C.D. Poulter "Solid-Phase Synthesis of a Farnesylated CaaX Peptide Library: Inhibitors of the Ras CaaX Endoprotease," J. Combinatorial Chemistry 2000, 2, 522-536.

U. Mollmann, A. Ghosh, E.K. Dolence, J.A. Dolence, M. Ghosh, M.J. Miller, R. Reissbrodt "Selective growth promotion and growth inhibition of gram-negative and gram-positive bacteria by synthetic siderophore--lactam conjugates," Biometals 1998, 11, 1-12.

M.S. Diarra, M.C. Lavoie, M. Jacques, I. Darwish, E.K. Dolence, J.A. Dolence, A. Ghosh, M. Ghosh, M.J. Miller, F. Malouin "Species selectivity of new siderophore-drug conjugates that use specific iron uptake for entry into bacteria," Antimicrob. Agents Chemotherapy 1996, 40, 2610-7.

M.S. Diarra, J.A. Dolence, E.K. Dolence, I. Darwish, M.J. Miller, F. Malouin and M. Jacques "Growth of Actinobacillus pleuropneumoniae is Promoted by Exogenous Hydroxamate and Catechol Siderophores," Applied and Environmental Microbiology 1996, 62, 853-859.

A. Minnick, J.A. McKee, E.K. Dolence and M.J. Miller "Iron Transport-Mediated Antibacterial Activity of and Development of Resistance to Hydroxamate and Catechol Siderophore-Carbacephalosporin Conjugates," Antimicrob. Agents Chemotherapy 1992, 36, 840-850.

A. Brochu, N. Brochu, T.I. Nicas, T.R. Parr, Jr., A.A. Minnick, E.K. Dolence, J.A. McKee, M.J. Miller, M.C. Lavoie and F. Malouin "The Mode of Action and Inhibitory Activity of New Siderophore--lactam Conjugates that use Specific Iron Uptake Pathways for entry into Bacteria," Antimicrob. Agents Chemotherapy 1992, 36, 2166-75.

E.K. Dolence, A.A. Minnick, M.J. Miller and S.M. Payne "Synthesis, Siderophore and Antibacterial Activity of N5-Acetyl-N5-Hydroxy-L-Ornithine Derived Siderophore--Lactam Conjugates: Iron Transport Mediated Drug Delivery," J. Med. Chem. 1991, 34, 968-978.

E.K. Dolence and M.J. Miller "Synthesis of Foroxymithine, a Microbial Fermentation Product and Angiotensin 1 Converting Enzyme Inhibitor," J. Org. Chem. 1991, 56, 492-499

E.K. Dolence, C. Lin, M.J. Miller, and S.M. Payne "Synthesis and Siderophore Activity of Albomycin-like Peptides Derived From N5-Acetyl-N5-Hydroxy-L-Ornithine," J. Med. Chem. 1991, 34, 956-968.

A.A. Minnick, L.E. Eizember, J.A. McKee, E.K. Dolence, and M.J. Miller "Bioassay for Siderophore Utilization by Candida albicans, " Anal. Biochem. 1991, 194, 223-229.

M.J. Miller, J.A. McKee, A.A. Minnick, and E.K. Dolence "The Design, Synthesis and Study of Siderophore-Antibiotic Conjugates: Siderophore Mediated Drug Transport," Biology of Metals 1991, 4, 62-69.

E.K. Dolence, A.A. Minnick, and M.J. Miller "N5-Acetyl-N5-Hydroxy-L-Ornithine Derived Siderophore-Carbacephalosporin -Lactam Conjugates: Iron Transport Mediated Drug Delivery," J. Med. Chem. 1990, 33, 461-463.

K. Kawada, E.K. Dolence, H. Morita, T. Kometani, D.S. Watt, A. Balapure, T.A. Fitz, D.J. Orlicky, and L.E. Gerschenson "Prostaglandin Photoaffinity Probes: Synthesis and Biological Activity of Azide-substituted 16-Phenoxy and 17-Phenyl PGF2 Prostaglandins," J. Med. Chem. 1989, 32, 256-264.

E.K. Dolence, H. Morita, D.S. Watt, and T. Fitz "Utilization of a Nitrenium Ion Cyclization in a Synthesis of a Photo-active Prostaglandin, 17-(4-Azido-2-hydroxyphenyl)-18,19,20-trinorprostaglandin F2," Tetrahedron Lett. 1987, 28, 43-46.

A. S. Demir, M.R. Sabol, A. Jeganathan, E.K. Dolence, and D.S. Watt "Synthesis of Biological Markers in Fossil Fuels 5. A Synthesis of 5-Cholanic Acid," Org. Prep. Proc. Inter. 1987, 19(2-3), 197-208.

E.K. Dolence, M. Adamczyk, D.S. Watt, G.B. Russell, and D.H.S. Horn "A Stereoselective Synthesis of 1,2 Diols from -Hydroxyaldehydes," Tetrahedron Lett. 1985, 26, 1189-1192.

D.M. Houston, E.K. Dolence, B.T. Keller, U. Patel-Thombre, and R.T. Borchardt "Potential Inhibitors of S-Adenosyl-methionine Dependent Methyl Transferases. 9. 2',3'-Dialdehyde Derivatives of Carbocyclic Purine Nucleosides as Inhibitors of S-Adenosylhomocysteine Hydrolase," J. Med. Chem. 1985, 28, 471-477.

D.M. Houston, E.K. Dolence, B.T. Keller, U. Patel-Thombre, and R.T. Borchardt "Potential Inhibitors of S-Adenosyl-methionine Dependent Methyl Transferases. 8. Molecular Dissections of Carbocyclic 3-Deazaadenosine as Inhibitors of S-Adenosylhomocysteine Hydrolase," J. Med. Chem. 1985, 28, 467-471.

M. Adamczyk, E.K. Dolence, D.S. Watt, M.R. Christy, J.H. Reibenspies, and O.P. Anderson "A New Procedure for the One-Carbon Homologation of Ketones to -Hydroxyaldehydes," J. Org. Chem. 1984, 49, 1378-1382.