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Family and Consumer Sciences|College of Agriculture and Natural Resources

Kenneth Shane Broughton, Ph.D.

Associate Professor
Human Nutrition and Food Program Option

 

Positions

Associate Professor of Nutrition, University of Wyoming, 1996 - present
Assistant Professor of Nutrition, University of Wyoming, 1990 - 1996
Wyoming Nutrition Specialist for AIDS and HIV  (Jan 1994-2006)
Research Associate, Senior Post-Doctoral Fellow, Lipids Research Laboratory, Institute of Food Science, Cornell University, Ithaca, NY, 1988 - 1990
Instructor, Department of Food Science and Human Nutrition, Washington State University, Pullman, WA, 1997 - 1998


Education

Ph.D. Human Nutrition – Washington State University - 1988
M.S. Biochemistry – Washington State University -1985
B.S. Biology – Colorado State University – 1981


Instruction

Nutrition Research Methods (FCSC 5142)
Lipids II - Lipoproteins and Eicosanoids (FCSC 5144)
Nutrition and the Elderly (FCSC 4142)
Maternal, Infant and Adolescent Nutrition (FCSC 3140)
Principles of Nutrition (FCSC 1141)
Nutrition (FCSC 1140)
General Biology (LIFE 1010)


Research Interest

My research interests concern evaluation of the effect of diet on health and disease focusing on the omega-3 fatty acids of marine and agricultural origin and their impact on inflammatory processes.  The two primary foci of my research are in the areas of asthma and ovulation.

These two disease pathologies though not directly related are tied together through a class of compounds known as the eicosanoids.  Leukotrienes, one member of this family, are very involved in the myriad of problems associated with asthma, including mucous infiltration and airway constriction.  Our research has identified classes within the asthmatic family that indicate that different types of asthmatics exist based on the metabolites involved and their responsiveness to both omega-3 fatty acids and pharmacologic intervention.  We are attempting to characterize these subtypes and to develop a diagnostic tool that will allow for clinical identification of type for more effective individualized treatment based on type.

Ovulation is the best characterized inflammatory process and responds to diet in a similar manner.  Impaired fecundity affects approximately 4.9 million married and unmarried women in the US.  Of that number 2.4 million meet the standard medical definition of infertility.  Diagnostic treatment costs for infertility range from $2,500 to $10,000 with medical treatment success rates of 50%.  Much of the problems with compromised ovulation may be associated with imbalances in the diet or the development of the disorder known as Polycystic Ovarian Syndrome (PCOS), known to afflict 6 – 10% of all women of reproductive age.  Studies to date have established that n-3 polyunsaturated fatty acids (PUFA) are proovulatory in the rat, an effect induced through alterations in the prostaglandins, another member of the eicosanoid family.  Further, particular drugs have also been found to alter ovulation, depending on the dose or route of administration.  It is my desire to ascertain to what degree diet and drugs may interfere with ovulation and the mechanisms involved.  I would like to determine if dietary intervention can successfully ameliorate PCOS related infertility and reduce the incidence of problems associated with PCOS including reduced insulin sensitivity, the development of type-2 diabetes, an increased incidence of endometrial, ovarian and uterine cancers (8-fold increase in all) along with hindered reproductive capacity.


Recent Publications

2011 Broughton KS, Rule DC, Handrich E Prostaglandin E2 Production in Mice is Reduced by Consumption of Range-Fed Sources of Red Meat. Nutrition Research 31:907-914

2010 Platt J, Kuzmanov A, Halliday T, Lindmier M, Peterson N, Broughton KS. Omega-3 fatty acid and vitamin D ingestion and leptin and adiponectin in PCOS 13th World Congress on Controversies in Obstetrics, Gynecology and Infertility (COGI) 355-359

2010 Kuzmanov A, Broughton KS. Role of marine omega-3 fatty acids in PCOS cancer risk. 13th World Congress on Controversies in Obstetrics, Gynecology and Infertility (COGI) 349-354

2010 Broughton KS, Bayes J, Culver B. High α-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. Nutrition Research 30:731-738

2009 Broughton KS, Hahn B, Ross E. Docosahexaenoic acid and eicosapentaenoic acid differently affect ovarian prostaglandin levels in rats. Nutrition Research 29:510-518

2009 Broughton KS, Rule DC, Yi Ye, Zhang  X, Driscoll M, Culver B. Dietary omega-3 fatty acids differentially influence ova release and ovarian COX-1 and COX-2 expression in rats. Nutrition Research 29:197-205


Patents

2011 Broughton KS.  Patent submission: Individualized Treatment for Leukotriene Asthma Subtypes

2007 Broughton KS.  Provisional submission: Differentiation of Leukotriene Based Asthmatics

2005 Broughton KS.  Patent of Asthma diagnostic tool.


Presentations form National/International Meetings

2010 Kuzmanov A, Broughton KS. Influence of omega-3 fatty acid ingestion on hormones related to polycystic ovarian syndrome infertility. 13th World Congress on Controversies in Obstetrics, Gynecology and Infertility (COGI) November 4-7, 2010 – Berlin, Germany

2010 Platt J, Kuzmanov A, Halliday T, Lindmier M, Peterson N, Broughton KS. Omega-3 fatty acid and vitamin D ingestion and leptin and adiponectin in PCOS. 13th World Congress on Controversies in Obstetrics, Gynecology and Infertility (COGI) November 4-7, 2010 – Berlin, Germany

2009 Ross E, Broughton KS, Johnson K. Subclassification of Leukotriene-Based Asthmatics.  FASEB J.

2008 Broughton KS, Hahn BL, Ross EC, Heidal KB. The Influence of Docosahexaenoic Acid DHA on Rat Ovulation.  FASEB J.

2008 Heidal KB, Broughton KS, Malinauskas BM, Hickner RC, Duffrin MW. Relationship Among Omega-3 fatty acids, Anthropometrics, and Biochemical Markers in College Students. FASEB J.

2007 Barber-Heidal K, Broughton KS, Hickner R, Malinaskis B.  Co-morbidities Associated With Obesity and the Role of Omega-3 Fatty Acid Intake in Free-living Healthy Weight, Overweight and Obese College Students.  FASEB J.

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