Zoology and Physiology

College of Agriculture, Life Sciences and Natural Resources

Zhaojie Zhang

Director, Microscopy Facility

zzhang@uwyo.edu • (307) 766-3038 • Bio Sciences 29

Education:

• B.S. Shandong University
• M.S. Shandong University
• Ph.D. University of Oklahoma 

Teaching

• Biological Confocal Microscopy (ZOO5740) - offered in Spring semesters

Publications:
Vuković LD, Jevtić P, Zhang Z, Stohr BA, Levy DL (2016). Nuclear size is sensitive to NTF2 protein levels dependent on Ran binding. J Cell Sci. 129:1115-1127. doi:10.1242/jcs.181263

Zhang X, Liu X, Bian W, Xu C, Wu Y, Zhang Z (2015). Genome-wide transcriptome analysis of yeast SOD1 deletion mutant in response to Congo Red stress. Chin J Biochem Mol Biol 31(9): 960-966.

Zhang Z and Ren Q (2015). Why are essential genes essential? – The essentiality of Saccharomyces genes. Microbial Cell, 2 (8): 280 - 287; DOI: 10.15698/mic2015.08.218

Fu J, Hou J, Chen L, Wang M, Shen Y, Zhang Z, Bao X. (2015): The yeast BDF1 regulates endocytosis via LSP1 under salt stress. Curr Microbiol. 70(5):671-8.

Wang S, Zhang S, Liou L-C, Ren Q, Zhang, Z, Caldwell G, Caldwell K and Witt SN (2014). Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease. PNAS, 111 (38): E3976-85

Liou L-C, Ren Q, Gao Q and Zhang Z (2014). Sro7 and Sro77, the yeast homologues of the Drosophilalethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway. Microbiology 160: 2208-2214

Liu X, Zhang X and Zhang Z. (2014). Point mutation of H3/H4 histones affects acetic acid tolerance in Saccharomyces cerevisiae. Journal of Biotechnology 187:116–123

Gao Q, Liou L, Ren Q, Bao Xiao and Zhang Z (2014). Salt stress causes cell wall damage in yeast cells lacking mitochondrial DNA. Microbial Cell 1(3): 94-99

Chen L, Wang M, Hou J, Liu L, Fu J, Shen Y, Zhang Z and Bao X (2014). Regulation of Saccharomyces cerevisiae MEF1 by Hda1p affects salt resistance of bdf1D mutant. FEMS Yeast Res. 14 (4):575-585

Chen J, Marks E, Lai B, Zhang Z, Duce JA, Lam LQ, Volitakis I, Bush AI, Hersch S, Fox JX (2013) Iron accumulates in Huntington’s disease neurons: protection by deferoxamine. PLOS ONE 10.1371/journal.pone.0077023

Wang S, Horn PJ, Liou LC; Muggeridge MI, Zhang Z, Chapman KD, Witt SN (2013) A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast. Biochemical and Biophysical Research Communications 438(2):452-456

Fu J, Hou J, Liu L, Chen L, Wang M, Shen Y, Zhang Z, Bao X. (2013). Interplay between BDF1 and BDF2 and their roles in regulating the yeast salt stress response. FEBS Journal 280:1991-2001

Chen L, Liu L, Wang M, Fu J, Zhang Z, Hou J and Bao X (2013). Hal2p Functions in Bdf1p-Involved Salt Stress Response in Saccharomyces cerevisiae. PLOS ONE 8 (4):e62110

Wang S, Xu B, Liou LC, Ren Q,  Huang S, Luo Y, Zhang Z, and Witt SN (2012) α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. PNAS, 2 (109):16119-16124

Ren Q, Liou LC, Gao Q, Bao X Zhang Z (2012) Bir1 deletion causes malfunction of the spindle assembly checkpoint and apoptosis in yeast. Frontier in Oncology. 2:article 93 (doi: 10.3389/fonc.2012.00093)  

Zechmann, B; Liou, L; Koffler, B; Horvat, L; Tomašić, A; Fulgosi, H; Zhang, Z (2011). Subcellular distribution of glutathione and its dynamic changes under oxidative stress in the yeast Saccharomyces cerevisiae. FEMS Yeast Res. 11: 631–642

Flynn FW, Jensen DD, Thakar A, Xu X, Flynn SW, Zhang Z. (2011) Neurokinin 3 receptor forms a complex with acetylated Histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge. Am J Physiol Regul Integr Comp Physiol 301: R822–R831

Liu X, Lee YJ, Liou LC, Ren Q, Zhang Z, Wang S, Witt SN. (2011). Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast. Hum Mol Genet. 20(17):3401-14

Gao Q, Ren Q, Liou LC, Bao X, and Zhang Z (2011). Mitochondrial DNA protects against salt stress-induced cytochrome c-mediated apoptosis in yeast. FEBS Letters 585:2507-2512

Weinberger M, Mesquita A, Carroll, T Marks L, Yang H, Zhang Z, Ludovico P, and Burhans WC (2010): Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. AGING, 2 (10): 1-18 

Liu X, Zhang X and ·Zhang Z (2010): Cu, Zn-superoxide dismutase is required for cell wall structure and for tolerance to cell wall-perturbing agents in Saccharomyces cerevisiae. FEBS Letters 584: 1245-1250

Liu X, Yang H, Zhang X, Liu L, Lei M, Zhang, Z, Bao X (2009) BDF1 Deletion Affects Mitochondrial Function and Causes Apoptotic Cell Death under Salt Stress. FEMS Yeast Res  9: 240-246

Zhang Z and Ren Q (2009) Micro and nanoscopic observation of biological surfaces.  In "Characterization and technological applications of bio-inspired surfaces" eds. E. Favret and N. O. Fuentes. World Scientific Publishing Co., pp 135-154

Yang H, Ren Q and Zhang Z (2008) Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast. Molecular Biology of the Cell, 19(5):2127-2134

Ren Q, Yang H, Gao B and Zhang Z (2008) Global transcriptional analysis of yeast cell death induced by mutation of sister chromatid cohesin. Comparative and Functional Genomics Volume 2008, Article ID 634283 doi:10.1155/2008/634283

Jensen D, Zhang, Z and Flynn FW (2008) Trafficking of tachykinin NK3 receptor to nuclei of neurons in the paraventricular nucleus of the hypothalamus following osmotic challenge. Neuroscience 155 (1): 308-316.

Yang L, Fang M, Du L, Zhang Z, Ren L, Yu X (2008) Synthesis and photoluminescence properties of CaSiO3:Eu3+ nanospheres prepared by the reverse micelles soft template. Materials Research Bulletin 43(10):2538-2543

Xu P, Li SY, Li Q, Van Kirk EA, Ren J, Murdoch WJ, Zhang Z, Radosz M, Shen Y (2008) Virion-Mimicking Nanocapsules from pH-Controlled Hierarchical Self-Assembly for Gene Delivery. Angewandte Chemie 120 (7): 1280-1284

Flower TR, Clark-Dixon C, Metoyer C, Yang H, Shi R, Zhang Z and Witt SN (2007)Targeting A30P Alpha-Synuclein to the Vacuole for Degradation by YGR198w (YPP1) Journal of Cell Biology 177:1091-1104

Zhang Z (2006) A multi-axial stage for stereo dissecting microscope. Microscopy Today 14 (5): 48

Yang H, Ren Q and Zhang Z (2006) Chromosome or chromatin condensation leads to meiosis or apoptosis in stationary yeast (Saccharomyces cerevisiae) cells. FEMS Yeast Res. 6(8):1254-1263.

Website: Visit the Web site of the Robert A. Jenkins Microscopy Facility