Some of the content on this website requires JavaScript to be enabled in your web browser to function as intended. While the website is still usable without JavaScript, it should be enabled to enjoy the full interactive experience.

Skip to Main Navigation. Each navigation link will open a list of sub navigation links.

Skip to Main Content

Faculty|Graduate Neuroscience Program
Associate Professor, Department of Veterinary Science

Jonathan Fox

Publications
Students

 

 

Research 

Huntington’s disease (HD) is a genetically dominant disorder characterized by involuntary movements as well as psychiatric disturbances and cognitive decline.  In the United States there are about 30,000 people with HD.  We use cell and mouse models of HD to elucidate mechanisms of brain degeneration in this chronic and fatal disease.  Findings from our mechanistic studies are used to generate hypotheses relating to potential protective therapeutic interventions.  We test these interventions in genetically accurate mouse models of HD.  We focus on the role of oxidative stress in HD neurodegeneration.  A specific area of interest is the role of dysregulated iron metabolism as a potentiating factor in HD.  We are also studying a modulatory role of dietary selenium intake in HD mice.  Our goal is to contribute to the accumulating body of scientific understanding that will eventually lead to effective prevention and treatment of human HD and related degenerative diseases.

June 2012:  Currently interested in hearing from those seeking research positions (technician or post-doctoral fellow) in neurodegeneration.  Research involves working with mouse and cell models of Huntington’s disease.  Experience or specific interest in polyglutamine disease research preferred.

Education

BSc, University of Liverpool
BVSc, University of Liverpool
PhD, Virginia Polytechnic Institute and State University
Dip, ACVP
Research Fellow, Massachusetts General Hospital / Harvard University

Teaching

Neuroanatomy for medical students, WWAMI program
Diseases of Food Animals and Horses 

Share This Page:

Footer Navigation

University of Wyoming Medallion
 
1000 E. University Ave. Laramie, WY 82071 // UW Operators (307) 766-1121 // Contact Us // Download Adobe Reader