Skip to Main Navigation. Each navigation link will open a list of sub navigation links.

Skip to Main Content

Apply to the University of Wyoming apply now

Global Resource Navigation

Visit Campus
Download UW Viewbook
Give to UW
UW Sensory Biology COBRE
Menu

Contact Us

Dr. Qian-Quan Sun, SBC director, Professor

Department of Zoology and Physiology

Laramie, WY 82071

Phone: 307-766-5602

Email: neuron@uwyo.edu

Find us on Facebook (Link opens a new window)

SBC Project Leaders

Project-001 how an olfactory sensory neuron's choice of odorant receptor gene determines its wiring

Project Leader:  Dr. Stephen Santoro, Assistant Professor, Department of Zoology and Physiology

Santoro

Project Narrative. The precise creation and modulation of connections within the nervous system are known to critically depend on neuronal activity as well as the local synthesis of proteins within nerve termini. In this project, we are investigating the mechanisms by which sensory neuronal activity mediates the development and modulation of connectivity within the mammalian olfactory system, including the identification of key transcription factors and the elucidation of the role of axonal protein synthesis. Our studies employ the mouse model, which has an olfactory system organization that is similar to that of humans and which enables the use of powerful molecular and genetic tools for investigating mechanisms of activity-dependent development and plasticity. These studies may potentially lead to insights into the causes of neurodevelopmental and neurodegenerative disorders, which have been linked to defects in molecular components of activity-dependent signaling pathways and axonal protein synthesis, as well as the causes of age-related olfactory dysfunction, which affects a large fraction of people over the age of 65.
Project-002 The role of presenilin in a developing visual circuit

Project Leader:  Dr. Kara Pratt, Associate Professor, Department of Zoology and Physiology

Pratt

Project Narrative. The precise creation and modulation of connections within the nervous system has long been known to depend on neuronal activity and, more recently, has been found to require local protein synthesis within dendrites and axons. Enhancing our understanding of the mechanisms that underlie the formation and alteration of neuronal connectivity promises to yield insights into the causes of neurodevelopmental and neurodegenerative disorders, many of which have been linked to defects in components of activity-dependent signaling pathways (Ebert and Greenberg, 2013) and axonal mRNA translation (Jung et al., 2012). Here we propose to study these processes within the mouse olfactory system, which offers a superb platform for investigating mechanisms of activity-dependent neural connectivity and plasticity.

Project-003  Modulation of Pain Signaling Mechanisms by Botulinum Neurotoxin A

Project Leader:  Dr. Baskaran Thyagarajan, Associate Professor, College of Health Sciences

Baski


Project Narrative. This proposal investigates the novel mechanisms by which botulinum neurotoxin A suppresses pain, by inhibiting the sensitization of TRPV1/TRPA1 channel proteins by PKC and advances the safe, site specific use of the neurotoxin to counteract pain without use dependence or addiction.

Pilot projects: Pilot projects will be selected and announced in 2018

bucking-horse


Share This Page:

Contact Us

Dr. Qian-Quan Sun, SBC director, Professor

Department of Zoology and Physiology

Laramie, WY 82071

Phone: 307-766-5602

Email: neuron@uwyo.edu

Find us on Facebook (Link opens a new window)

1000 E. University Ave. Laramie, WY 82071
UW Operators (307) 766-1121 | Contact Us | Download Adobe Reader

Twitter Icon Youtube Icon Instagram Icon Facebook Icon

Accreditation | Emergency Preparedness | Employment at UW | Gainful Employment | Privacy Policy | Accessibility Accessibility information icon