Wyoming Technology Transfer and Research Products Center
Dept. 3672
1000 E. University Ave.
Laramie, WY 82071
Phone: (307) 766-2520
Fax: (307) 766-2530
Email: WyomingInvents@uwyo.edu
According to the Center for Disease Control, more than one third of American adults are considered obese. Obesity foreshadows metabolic dysfunctions and leads to type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases. An imbalance between energy intake and expenditure caused by sedentary life style, lack of physical exercise and preference for fat-rich food leads to obesity. As a result, obesity impacts the physiological and psychological well-being of society as a whole from an individual and public health perspective. Therefore, it is important to develop strategies to counteract obesity and metabolic diseases.
Researchers at the University of Wyoming have created a research plan to determine the effect of dietary CAP, to evaluate the effect of dietary CAP after adding in TRPV1, and to deduce the mechanism by which a high fat diet suppresses TRPV1 expression in adipose tissue. They have also created animal (mice) models available for conducting research in this area.
These innovative approaches will explain the role of non-neuronal, adipose tissue specific expression and activity of TRPV1.
The work will also add new knowledge on the regulation of TRPV1 expression by adipose tissue derived BDNF.
This research will significantly advance our current knowledge on the role of TRPV1 specifically expressed and localized in adipose tissues in the regulation of metabolism and energy expenditure.
The activation of TRPV1 protein is believed to be beneficial in countering diet-induced obesity.
This research will contribute to long-term goals for developing new pharmacotherapy to counter obesity.
Downloadable PDF: 16-102
Thyagarajan, Baskaran
Baskaran, Padma
Patent Pending
University of Wyoming Technology Transfer and Research Products Center
Dept. 3672
1000 E. University Ave.
Laramie, WY
82071
Phone: 307-766-2520
Fax: 307-766-2530
Email: WyomingInvents@uwyo.edu
Wyoming Technology Transfer and Research Products Center
Dept. 3672
1000 E. University Ave.
Laramie, WY 82071
Phone: (307) 766-2520
Fax: (307) 766-2530
Email: WyomingInvents@uwyo.edu