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Molecular Biology

Department of Molecular Biology
University of Wyoming
Agriculture C 6033
1000 E. University Ave.
Laramie, WY 82071

Email: jgigley@uwyo.edu

Phone: (307) 766-6151


Department of Molecular Biology

College of Agriculture and Natural Resources

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Gigley Lab: Publications

  1. Gigley J.P., Bhadra R, Moretto M.M., Khan I.A. (2012) T cell exhaustion in protozoan disease. Trends Parasitol. 2012 Sep;28(9):377-84.
  2. Bhadra, R., Gigley, J.P. and Khan, I.A. (2012) PD-1 mediated attrition of polyfunctional memory CD8+ T cells in chronic Toxoplasma infection. J. Infect. Dis. 206(1):125-34.
  3. Bhadra, R.J., Gigley, J.P. and Khan I.A. (2011) CD40-CD40L pathway plays a critical CD8 intrinsic and extrinsic role during rescue of exhausted CD8 T cells. Cutting Edge J. Immunol. 187(9):4421-5.
  4. Gigley, J.P. and Khan, I.A. (2011) Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection. PLoS ONE. 6(6):e20838.
  5. Bhadra, R.J*, Gigley, J.P.* and Khan, I.A*. (2011) Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PD-L1 blockade. Proc. Natl. Acad. Sci. U S A. 108(22):9196-201. (* equal contribution)
  6. Bhadra, R.J. Gigley, J.P. and Khan, I.A. (2011) The CD8 T cell road to immunotherapy of toxoplasmosis. Immunother. 3(6):789-801.
  7. Fox, B.A., Falla, A., Rommereim, L.M., Tomita, T., Gigley, J.P., Mercier, C., Cesbron-Delaw, M.F., Weiss, L.M., and Bzik, D.J. (2011) Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection. Eukaryot. Cell. Sep;10(9):1193-20
  8. Gigley, J.P., Bhadra R.J. and Khan, I.A. (2011) CD8 T cells and Toxoplasma gondii: A new paradigm. J. Parasitol. Res. 2011:243796.
  9. Balsley, M.A., Malesevic, M., Gigley, J., Herzog,D., Bukrinsky, M.I., Fischer,G. Constant, S.L. (2010) A cell-impermeable derivative of Cyclosporine A reduces disease pathology in a mouse model of acute allergic asthma. J. Immunol. 185(12):7663-70.
  10. Gigley, J.P., Fox B.A, and Bzik, D.J. (2009) Long-term immunity to lethal acute or chronic Type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated Type I vaccine strain. Infect. and Immun. 77(12) 5380-8.
  11. Fox B.A., Ristuccia J.G., Gigley J.P., Bzik D.J. (2009) Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining. Eukaryot. Cell. 8(4):520-9.
  12. Beaver L.M., Stemmy E.J., Constant S.L., Schwartz A., Little L.G., Gigley J.P., Chun G., Sugden K.D., Ceryak S.M., Patierno S.R. (2009) Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium. Toxicol Appl. Pharmacol. 235(1):47-56.
  13. Gigley, J.P., Fox, B.A., Bzik, D.J. (2009) Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. J Immunol. 182(2):1069-78.
  14. Guan, H., Moretto, M., Bzik, D.J., Gigley, J.P., Khan, I.A. (2007) NK cells enhance dendritic cell responses against parasite antigens via NKG2D pathway. J Immunol. 179(1):590-6.
  15. Combe, C.L., Moretto, M.M., Schwartzman, J.D., Gigley, J.P., Bzik, D.J., Khan, I.A. (2006) Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite. Proc. Natl. Acad. Sci (USA), 103: 6635-6640.
  16. Fox, B.A., Gigley, J.P. , Bzik, D.J. (2004) Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation. Int. J. Parasitol., 34(3): 323-331.
  17. Gabay C., Gigley J. , Sipe J., Arend W.P., Fantuzzi G. (2001) Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase protein in vivo. Eur. J. Immunol., 31(2): 490-499.
  18. Gabay C., Marinova-Mutafchieva L., Williams R.O., Gigley J.P., Butler D.M., Feldmann M., Arend W.P. (2001) Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis. Arthritis & Rheumatism, 44(2): 451-462.
  19. Kuhne M.R., Robins M., Hambor J.E., Mackey M.F., Kosaka Y., Nishimura T., Gigley J.P., Noelle R.J., Calderhead D.M., Assembly and regulation of the CD40 receptor complex in human B Cells. (1997) J. Exp. Med., 186(2): 337-342.

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