Skip to Main Navigation. Each navigation link will open a list of sub navigation links.

Skip to Main Content

Apply to the University of Wyoming apply now

Global Resource Navigation

Visit Campus
Download UW Viewbook
Give to UW

Faculty and Staff

Department of Chemistry

Robert Corcoran

Associate Professor
Synthetic Organic Chemistry

B.S., 1978, University of Chicago
Ph.D., 1983, Columbia University
NIH Postdoctoral Fellow, 1983-1985, University of California, Berkeley • (307) 766-2792 • PS 349


Our research focuses on applications of organic chemistry to analytical chemistry. Only rarely is it possible to directly determine the concentration of a target analyte in a sample matrix. Generally, the presence of numerous interferents having similar spectral characteristics to the target necessitates sample pretreatment, followed by some form of chromatography prior to the actual detection and quantification of the target. Indeed, much of the time and effort involved in most analytical methods are spent in this type of sample "clean-up." We are investigating a number of attractive alternatives to this traditional methodology. In one broad class of applications we construct sensor molecules that comprise a molecular recognition site for the target analyte (e.g., copper), a "reporter" subunit that undergoes a spectral change to a readily detectable form upon binding of the target, and a tethering group that has a high affinity for silver or gold. When a target containing sample is combined with the sensor, followed by addition of gold nanoparticles, the target-sensor complex binds to the nanoparticles and the amount of the complex can be determined using surface enhanced Raman scattering (SERS) spectroscopy. Using this method, we have demonstrated rapid (~10 sec) detection of bioavailable copper at a part-per-billion sensitivity. In a another approach to specific and sensitive analyte detection we have designed sensor molecules that undergo very selective reactions with certain compounds (e.g., nerve gas) to give intermediates that subsequently fragment to give readily detectable dyes. With this approach, we have demonstrated detection of sub-parts-per-million levels of nerve agent analogs in less than a minute.


Contact Us

Chemistry Department

Department 3838

1000 E. University Avenue

Physical Science Bldg 204

Laramie, WY 82071

Phone: 307-766-4363

Fax: 307-766-2807


Find us on Facebook (Link opens a new window)

1000 E. University Ave. Laramie, WY 82071
UW Operators (307) 766-1121 | Contact Us | Download Adobe Reader

Accreditation | Virtual Tour | Emergency Preparedness | Employment at UW | Gainful Employment | Privacy Policy | Harassment & Discrimination | Accessibility Accessibility information icon