Some of the content on this website requires JavaScript to be enabled in your web browser to function as intended. While the website is still usable without JavaScript, it should be enabled to enjoy the full interactive experience.

Skip to Main Content

School of Pharmacy|College of Health Sciences

Kurt Dolence, Ph.D.

Associate Professor of Medicinal Chemistry

kdolence@uwyo.edu • (307) 766-2954 • HS 398

Best Mode of Communication: E-mail

Office Hours: MW 3:00 - 4:30 p.m.

Education 

1987, University of Kentucky, Lexington, KY, Ph.D. Pharmaceutical Sciences 

1983, University of Wyoming, Laramie, WY, B.S. Pharmacy 

Professional Experience

2005 to present, Associate Professor of Medicinal Chemistry, University of Wyoming

January 2004 to present, Adjunct faculty Dept. of Chemistry, University of Wyoming

1999-2005, Assistant Professor of Medicinal Chemistry, University of Wyoming 

1996-1999, Post-Doctoral Research Associate, University of Utah, Department of Chemistry

1994-1996, Manager, Bioconjugate Chemistry; Surface Engineering Technologies (Division of InnerDyne, Inc.

1992-1994, Senior Research Scientist, CardioPulmonics, Inc.

1990-1992, Research Chemist, CardioPulmonics, Inc.

1987-1990, Post-Doctoral Research Associate, University of Notre Dame, Department of Chemistry

Research Interests:

Organic and bioorganic chemistry

Teaching:

Medicinal Chemistry

Publications:

REFEREED CHAPTERS IN BOOKS

M.J. Miller, F. Malouin, E.K. Dolence, C.M. Gasparski, M. Ghosh, P.R. Guzzo, B.T. Lotz, J.A. McKee, A.A. Minnick, and M. Teng; "Iron Transport-Mediated Drug Delivery", in Recent Advances in the Chemistry of Anti-infective Agents, Bentley, P. H.; Ponsford, R., Eds.; Royal Society of Chemistry: Cambridge, 1993, pp. 135-159.

REFEREED JOURNAL ARTICLES

Yamreudeewong, Weeranuj; Dolence, E. Kurt; Pahl, Deborah "Stability of Donepezil in an Extemporaneously Prepared Oral Liquid" J. of Pharmacy Practice, 2006, in press

Yamreudeewong, Weeranuj; Dolence, E. Kurt; Pahl, Deborah "Stability of two extemporaneously prepared oral Metoprolol and Carvedilol Liquids" Hospital Pharmacy 2006, 41, 254-259.

Mary Beth Flanders Stepans, Susan L. Wilhelm and E. Kurt Dolence "Smoking Hygiene: Reducing Infant Exposure to Tobacco" Biological Research for Nursing 2006, 8, 104-114.

Richard T. Mayer, E. Kurt Dolence, Gabriele E. Mayer "A Real-Time Fluorescence Assay for Measuring N-Dealkylation" Drug Metabolism and Disposition Published on-line October 11, 2006 as doi:10.1124/dmd.106.011601, in press.

Christine M. Lewis, E. Kurt Dolence, Catherine S. Hubbard and James D. Rose "Identification of roughskin newt medullary vasotocin target neurons with a fluorescent vasotocin conjugate" J. of Comparative Neurology 2005, 491, 381-389.

E.K. Dolence, Gabriele Mayer and Brenda D. Kelly "Optically Active Diethyl Sulfamidate 2-Phosphonates as Chiral Synthons for the Synthesis of b-Substituted a-Amino Phosphonates," Tetrahedron: Asymmetry 2005, 16, 1583-1594. 

Li, S-Yan; Du, M.; Dolence, E.K.; Fang, X.; Mayer, G.; Ceylan-Isik, A.F.; LaCour, K.; Yang, X.; Wilbert, J.C.; Sreejayan, N.; Ren, J. "Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation end products and protein modification" Aging Cell 2005 4, 57-64. 

C.M. Lewis, E.K. Dolence, Z. Zhang, J.D. Rose "Fluorescent Vasotocin Conjugate for Identification of the Target Cells for Brain Actions of Vasotocin," Bioconjugate Chemistry 2004, 15, 909-914. 

E.K. Dolence and Jason Roylance "Optically Active Diethyl N-(p-Toluenesulfonyl)-Aziridine 2-Phosphonates as Chiral Synthons for the Synthesis of b-Substituted a-Amino Phosphonates," Tetrahedron: Asymmetry 2004, 15, 3307-3322. 

P.R. Wade, E. Jacobson, K. Garcia, J. Lieb, E.K. Dolence, O.B. Balemba "Enterochromaffin cells and serotonergic neurons in the guinea pig distal colon are spared during aging," Neurogastr. Motility 2003, 15 (2), page 201. 

Flynn, F.W., Heyborne, R. & Dolence, K. (2001) Internalization of NK3 receptor agonist, senktide, following intraventricular injection in rat. Regulatory Peptides, 97, 47. 

E.K. Dolence, J.M. Dolence, C.D. Poulter "Solid-Phase Synthesis of a Radiolabeled, Biotinylated, and Farnesylated Ca¬1a2X Peptide Substrate for Ras- and a-Mating Factor Converting Enzyme," Bioconjugate Chemistry 2001, 12, 35-43.

J.M. Dolence, L.E. Steward, E.K. Dolence, D.H. Wong, C.D. Poulter "Studies with Recombinant Saccharomyces cerevisiae CaaX Prenyl Protease Rce1p," Biochemistry 2000, 39, 4096-4104.

E.K. Dolence, J.M. Dolence, C.D. Poulter "Solid-Phase Synthesis of a Farnesylated CaaX Peptide Library: Inhibitors of the Ras CaaX Endoprotease," J. Combinatorial Chemistry 2000, 2, 522-536.

U. Mollmann, A. Ghosh, E.K. Dolence, J.A. Dolence, M. Ghosh, M.J. Miller, R. Reissbrodt "Selective growth promotion and growth inhibition of gram-negative and gram-positive bacteria by synthetic siderophore--lactam conjugates," Biometals 1998, 11, 1-12.

M.S. Diarra, M.C. Lavoie, M. Jacques, I. Darwish, E.K. Dolence, J.A. Dolence, A. Ghosh, M. Ghosh, M.J. Miller, F. Malouin "Species selectivity of new siderophore-drug conjugates that use specific iron uptake for entry into bacteria," Antimicrob. Agents Chemotherapy 1996, 40, 2610-7.

M.S. Diarra, J.A. Dolence, E.K. Dolence, I. Darwish, M.J. Miller, F. Malouin and M. Jacques "Growth of Actinobacillus pleuropneumoniae is Promoted by Exogenous Hydroxamate and Catechol Siderophores," Applied and Environmental Microbiology 1996, 62, 853-859.

A. Minnick, J.A. McKee, E.K. Dolence and M.J. Miller "Iron Transport-Mediated Antibacterial Activity of and Development of Resistance to Hydroxamate and Catechol Siderophore-Carbacephalosporin Conjugates," Antimicrob. Agents Chemotherapy 1992, 36, 840-850.

A. Brochu, N. Brochu, T.I. Nicas, T.R. Parr, Jr., A.A. Minnick, E.K. Dolence, J.A. McKee, M.J. Miller, M.C. Lavoie and F. Malouin "The Mode of Action and Inhibitory Activity of New Siderophore--lactam Conjugates that use Specific Iron Uptake Pathways for entry into Bacteria," Antimicrob. Agents Chemotherapy 1992, 36, 2166-75.

E.K. Dolence, A.A. Minnick, M.J. Miller and S.M. Payne "Synthesis, Siderophore and Antibacterial Activity of N5-Acetyl-N5-Hydroxy-L-Ornithine Derived Siderophore--Lactam Conjugates: Iron Transport Mediated Drug Delivery," J. Med. Chem. 1991, 34, 968-978.

E.K. Dolence and M.J. Miller "Synthesis of Foroxymithine, a Microbial Fermentation Product and Angiotensin 1 Converting Enzyme Inhibitor," J. Org. Chem. 1991, 56, 492-499

E.K. Dolence, C. Lin, M.J. Miller, and S.M. Payne "Synthesis and Siderophore Activity of Albomycin-like Peptides Derived From N5-Acetyl-N5-Hydroxy-L-Ornithine," J. Med. Chem. 1991, 34, 956-968.

A.A. Minnick, L.E. Eizember, J.A. McKee, E.K. Dolence, and M.J. Miller "Bioassay for Siderophore Utilization by Candida albicans, " Anal. Biochem. 1991, 194, 223-229.

M.J. Miller, J.A. McKee, A.A. Minnick, and E.K. Dolence "The Design, Synthesis and Study of Siderophore-Antibiotic Conjugates: Siderophore Mediated Drug Transport," Biology of Metals 1991, 4, 62-69.

E.K. Dolence, A.A. Minnick, and M.J. Miller "N5-Acetyl-N5-Hydroxy-L-Ornithine Derived Siderophore-Carbacephalosporin -Lactam Conjugates: Iron Transport Mediated Drug Delivery," J. Med. Chem. 1990, 33, 461-463.

K. Kawada, E.K. Dolence, H. Morita, T. Kometani, D.S. Watt, A. Balapure, T.A. Fitz, D.J. Orlicky, and L.E. Gerschenson "Prostaglandin Photoaffinity Probes: Synthesis and Biological Activity of Azide-substituted 16-Phenoxy and 17-Phenyl PGF2 Prostaglandins," J. Med. Chem. 1989, 32, 256-264.

E.K. Dolence, H. Morita, D.S. Watt, and T. Fitz "Utilization of a Nitrenium Ion Cyclization in a Synthesis of a Photo-active Prostaglandin, 17-(4-Azido-2-hydroxyphenyl)-18,19,20-trinorprostaglandin F2," Tetrahedron Lett. 1987, 28, 43-46.

A. S. Demir, M.R. Sabol, A. Jeganathan, E.K. Dolence, and D.S. Watt "Synthesis of Biological Markers in Fossil Fuels 5. A Synthesis of 5-Cholanic Acid," Org. Prep. Proc. Inter. 1987, 19(2-3), 197-208.

E.K. Dolence, M. Adamczyk, D.S. Watt, G.B. Russell, and D.H.S. Horn "A Stereoselective Synthesis of 1,2 Diols from -Hydroxyaldehydes," Tetrahedron Lett. 1985, 26, 1189-1192.

D.M. Houston, E.K. Dolence, B.T. Keller, U. Patel-Thombre, and R.T. Borchardt "Potential Inhibitors of S-Adenosyl-methionine Dependent Methyl Transferases. 9. 2',3'-Dialdehyde Derivatives of Carbocyclic Purine Nucleosides as Inhibitors of S-Adenosylhomocysteine Hydrolase," J. Med. Chem. 1985, 28, 471-477.

D.M. Houston, E.K. Dolence, B.T. Keller, U. Patel-Thombre, and R.T. Borchardt "Potential Inhibitors of S-Adenosyl-methionine Dependent Methyl Transferases. 8. Molecular Dissections of Carbocyclic 3-Deazaadenosine as Inhibitors of S-Adenosylhomocysteine Hydrolase," J. Med. Chem. 1985, 28, 467-471.

M. Adamczyk, E.K. Dolence, D.S. Watt, M.R. Christy, J.H. Reibenspies, and O.P. Anderson "A New Procedure for the One-Carbon Homologation of Ketones to -Hydroxyaldehydes," J. Org. Chem. 1984, 49, 1378-1382.

Share This Page:

Kurt Dolence, Ph.D.

Kurt Dolence, Ph.D.

Footer Navigation

University of Wyoming
 
1000 E. University Ave. Laramie, WY 82071 // UW Operators (307) 766-1121 // Contact Us