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Department of Molecular Biology

College of Agriculture and Natural Resources

 

Bridget Decker

Bridget Decker, Ph.D.

Lecturer, Asst. ETT

Department of Molecular Biology
Dept. 3944
1000 E. University Ave.
University of Wyoming
Laramie, WY  82071


bdecker2@uwyo.edu

Office Address:
Ag C 5009
(307) 766-2029 (office)
(307) 766-5098 (fax)


Research Statement

My research focuses around identifying and characterizing membrane fusion modulating proteins and mechanisms used by the obligate intracellular parasites Toxoplasma gondii (T. gondii) and Encephalitozoon cuniculi (E. cuniculi) to invade and persist in host cells. 

Invasion relies on highly specialized parasite secretory organelles and their content secretion onto or into the host cell. These parasites organelles are created and maintained by vesicle-vesicle and vesicle-organelle membrane fusion. Once inside the host, the parasites reside in the parasitophorous vacuole (PV) where they grow and replicate.  To maintain the PV, the parasite proteins must direct host fusion events to allow for nutrient acquisition and to prevent host vacuole fusion.  By identifying and characterizing parasites proteins and the mechanisms they use, we can better understand the infections and potentially lay the groundwork for the development of effective drug targets.  



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Department of Molecular Biology

University of Wyoming

Department #3944

1000 E. University Ave.

Laramie, WY 82071

Phone: (307) 766-3300

Fax: (307) 766-5098

Email: mbiology@uwyo.edu

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